High-normal blood pressure is associated with increased resting sympathetic activity but normal responses to stress tests

Blood Pressure

Volumn 22, Issue 3, 2013, Pages 183-187

  Hering, Dagmara ^a   Kara, Tomas ^b,c   Kucharska, Wiesława ^a   Somers, Virend K ^c   Narkiewicz, Krzysztof ^a,c  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^c MAYO CLINIC   (United States)

Author keywords

Heart rate; High normal blood pressure; Hypertension; Laboratory stressors; Sympathetic nerve activity

Indexed keywords

ADULT; ARTICLE; BODY MASS; CHRONOTROPISM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EXERCISE TEST; FEMALE; HAND GRIP; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL STRESS; MUSCLE SYMPATHETIC NERVE ACTIVITY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ADULT; EXERCISE TEST; FEMALE; HEART RATE; HUMANS; HYPERTENSION; MALE; SYMPATHETIC NERVOUS SYSTEM;

EID: 84877730595     PISSN: 08037051     EISSN: 16511999     Source Type: Journal    
DOI: 10.3109/08037051.2012.759689     Document Type: Article

References (24)

1. Lewington S, Clarke R, Q izilbash N, P eto R, C ollins R. A gespecifi c relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies . Prospective Studies Collaboration. Lancet . 2002; 360 : 1903-1913
2. Vasan RS, L arson MG, L eip EP, E vans JC, O ' D onnell CJ, Kannel WB, et al . Impact of high normal blood pressure on the risk of cardiovascular disease . N Engl J Med . 2001; 345 : 1291-1297
3. Esler M, L ambert G, B runner-La Rocca HP, V addadi G, Kaye D . Sympathetic nerve activity and neurotransmitter release in humans: Translation from pathophysiology into clinical practice . Acta Physiol Scand . 2003; 177 : 275-284
4. Grassi G. A ssessment of sympathetic cardiovascular drive in human hypertension: Achievements and perspectives . Hypertension . 2009; 54 : 690-697
5. Smith PA, G raham LN, M ackintosh AF, S toker JB, M ary DA . Relationship between central sympathetic activity and stages of human hypertension . Am J Hypertens . 2004; 17 : 217-222
6. Rea R F, H amdan M. B arorefl ex control of muscle sympathetic nerve activity in borderline hypertension . Circulation . 1990; 82 : 856-862
7. Floras JS, S enn BL. A bsence of post exercise hypotension and sympathoinhibition in normal subjects: Additional evidence for increased sympathetic outfl ow in borderline hypertension . Can J Cardiol . 1991; 7 : 253-258
8. Somers VK, M ark AL, A bboud FM. P otentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects . Hypertension . 1988; 11 : 608-612
9. Schobel HP, H eusser K, S chmieder RE, V eelken R, F ischer T, Luft FC . Evidence against elevated sympathetic vasoconstrictor activity in borderline hypertension . J Am Soc Nephrol . 1998; 9 : 1581-1587
10. A nderson EA, S inkey CA, L awton WJ, M ark A L. E levated sympathetic nerve activity in borderline hypertensive humans: Evidence from direct intraneural recordings . Hypertension . 1989; 14 : 177-183
11. Matsukawa T, G otoh E, U neda S, M iyajima E, S hionoiri H, Tochikubo O, et al . Augmented sympathetic nerve activity in response to stressors in young borderline hypertensive men . Acta Physiol Scand . 1991; 141 : 157-165
12. Greenwood JP, S toker JB, M ary DA. S ingle-unit sympathetic discharge: Quantitative assessment in human hypertensive disease . Circulation . 1999; 100 : 1305-1310
13. Charkoudian N, J oyner M J, S okolnicki L A, J ohnson CP, Eisenach JH, Dietz NM, et al . Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans . J Physiol . 2006; 572 : 821-827
14. Hassellund SS, Flaa A, S andvik L, K jeldsen S E, R ostrup M . Long-term stability of cardiovascular and catecholamine responses to stress tests: An 18-year follow-up study . Hypertension . 2010; 55 : 131-136
15. Fossum E, H ø i eggen A, R eims HM, M oan A, R ostrup M, Eide I, et al . High screening blood pressure is related to sympathetic nervous system activity and insulin resistance in healthy young men . Blood Press . 2004; 13 : 89-94
16. Flaa A, E ide I K, K jeldsen S E, R ostrup M. S ympathoadrenal stress reactivity is a predictor of future blood pressure: An 18-year follow-up study . Hypertension . 2008; 52 : 336-341
17. Lambert E A, S chlaich M P. R educed sympathoneural responses to the cold pressor test in individuals with essential hypertension and in those genetically predisposed to hypertension. No support for the " pressor reactor " hypothesis of hypertension development . Am J Hypertens . 2004; 17 : 863-868
18. Lambert EA, L ambert GW. S tress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome . Curr Hypertens Rep . 2011; 13 : 244-248
19. Esler M, E ikelis N, S chlaich M, L ambert G, A lvarenga M, Dawood T, et al . Chronic mental stress is a cause of essential hypertension: Presence of biological markers of stress . Clin Exp Pharmacol Physiol . 2008; 35 : 498-502
20. Palatini P. R ole of elevated heart rate in the development of cardiovascular disease in hypertension . Hypertension . 2011; 58 : 745-750
21. Grassi G, B olla G, S eravalle G, T urri C, L anfranchi A, Mancia G . Comparison between reproducibility and sensitivity of muscle sympathetic nerve traffi c and plasma noradrenaline in man . Clin Sci (Lond). 1997; 92 : 285-289
22. Esler M, J ennings G, L eonard P, S acharias N, B urke F, Johns J, et al . Contribution of individual organs to total noradrenaline release in humans . Acta Physiol Scand Suppl . 1984; 527 : 11-16
23. Wallin BG, T hompson JM, J ennings GL, E sler MD. R enal noradrenaline spillover correlates with muscle sympathetic activity in humans . J Physiol . 1996; 491 : 881-887
24. Grassi G, E sler M. H ow to assess sympathetic activity in humans . J Hypertens . 1999; 17 : 719-734