Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain

International Journal of Molecular Sciences

Volumn 14, Issue 5, 2013, Pages 9767-9778

  Okuyama, Satoshi ^a   Makihata, Nahomi ^a   Yoshimura, Morio ^a   Amakura, Yoshiaki ^a   Yoshida, Takashi ^a   Nakajima, Mitsunari ^a   Furukawa, Yoshiko ^a  

^a MATSUYAMA UNIVERSITY   (Japan)

Author keywords

Astrocyte; COX 2; Depression like behavior; Hippocampus; Inflammation; Lipopolysaccharide; Microglia; Oenothein B

Indexed keywords

ADAPTOR PROTEIN; CALCIUM BINDING ADAPTOR MOLECULE 1; ELLAGITANNIN; EUCALYPTUS GLOBULUS EXTRACT; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; OENOTHEIN B; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG; WATER; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; TANNIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENCEPHALITIS; ENZYME SYNTHESIS; EUCALYPTUS GLOBULUS; HIPPOCAMPUS; LOCOMOTION; MALE; MICROGLIA; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PROTEIN EXPRESSION; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; ONAGRACEAE; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HYDROLYZABLE TANNINS; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MICE; MICROGLIA; ONAGRACEAE; RNA, MESSENGER;

EID: 84877721560     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14059767     Document Type: Article

References (37)

1. Amakura, Y.; Yoshimura, M.; Sugimoto, N.; Yamazaki, T.; Yoshida, T. Marker constituents of the natural antioxidant Eucalyptus leaf extract for the evaluation of food additives. Biosci. Biotechnol. Biochem. 2009, 73, 1060-1065.
2. Ducrey, B.; Marston, A.; Göhring, S.; Hartmann, R.W.; Hostettmann, K. Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species. Planta Med. 1997, 63, 111-114.
3. Yoshida, T.; Chou, T.; Matsuda, M.; Yasuhara, T.; Yazaki, K.; Hatano, T.; Nitta, A.; Okuda, T. Woodfordin D and oenothein A, trimeric hydrolyzable tannins of macro-ring structure with antitumor actrivity. Chem. Pharm. Bull. 1991, 39, 1157-1162.
4. Tyler, V.E. Some recent advances in herbal medicines. Pharm. Int. 1986, 17, 161-169.
5. Vitalone, A.; McColl, J.; Thoma, D.; Costa, L.G.; Tita, B. Characterization of the effect of Epilobium extracts on human cell proliferation. Pharmacology 2003, 69, 79-87.
6. Schepetkin, I.A.; Kirpotina, L.N.; Jarissa, L.; Khlebnikov, A.I.; Blaskovich, C.L.; Jutila, M.A.; Quinn, M.T. Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium. J. Immun. 2009, 183, 6754-6766.
7. Tóth, B.H.; Blazics, B.; Kéry, Á. Polyphenol composition and antioxidant capacity of Epilobium species. J. Pharmacol. Biomed. Anal. 2009, 49, 26-31.
8. Kiss, A.K.; Bazylko, A.; Filipek, A.; Granica, S.; Jaszewska, E.; Kiarszys, U.; Kośmider, A.; Piwowarski, J. Oenothein B's contribution to the anti-inflammatory and anti-oxidant activity of Epilobium sp. Phytomedicine 2011, 18, 557-560.
9. Schmid, D.; Gruber, M.; Piskaty, C.; Woehs, F.; Renner, A.; Nagy, Z.; Kaltenboeck, A.; Wasserscheid, T.; Bazylko, A.; Kiss, A.K. et al. Inhibition of NF-κB-dependent cytokine and inducible nitric oxide synthesis by the macrocyclic ellagtannin oenothein B in TLR-stimulated RAW 264.7 macrophages. J. Nat. Prod. 2012, 75, 870-875.
10. Kiss, A.; Kowalski, J.; Melzig, M.F. Induction of neutral endopeptidase activity in PC-3 cells by aqueous extract of Epilobium angustifolium L. and oenothein B. Phytomedicine 2006, 13, 284-289.
11. Miyamoto, K.; Nomura, M.; Sasakura, M.; Matsui, E.; Koshiura, R.; Furukawa, T.; Hatano, T.; Yoshida, T.; Okuda, T. Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Jpn. J. Cancer Res. 1993, 84, 99-103.
12. Yoshida, T.; Hatano, T.; Ito, H. Chemistry and function of vegetable polyphenols with high molecular weights. Biofactors 2000, 13, 121-125.
13. Sakagami, H.; Jiang, Y.; Kusama, K.; Atsumi, T.; Ueda, T.; Toguchi, M.; Iwakura, I.; Satoh, H.; Ito, H.; Hatano, T. et al. Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines. A possible mechanism. Phytomedicine 2000, 7, 39-47.
14. Yoshimura, M.; Akiyama, H.; Kondo, K.; Sakata, K.; Matsuoka, H.; Amakura, Y.; Teshima, R.; Yoshida, T. Immunological effects of oenothein B, an ellagitannin dimer, on dendritic cells. Int. J. Mol. Sci. 2013, 14, 46-56.
15. Luheshi, G.N. Cytokines and fever. Mechanisms and sites of action. Ann. N. Y. Acad. Sci. 1998, 856, 83-89.
16. Dinarello, C.A. Cytokines as endogenous pyrogens. J. Infect. Dis. 1999, 179, S294-S304.
17. Kilbourn, R.G.; Belloni, P. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J. Natl. Cancer Inst. 1990, 82, 772-776.
18. Rivest, S. Molecular insights on the cerebral innate immune system. Brain Behav. Immun. 2003, 17, 13-19.
19. Matsumura, K.; Kaihatsu, S.; Imai, T.; Terao, A.; Shiraki, T.; Kobayashi, S. Cyclooxygenase in the vagal afferents. Is it involved in the brain prostaglandin response evoked by lipopolysaccharide? Auton. Neurosci. 2000, 85, 88-92.
20. Cao, C.; Matsumura, K.; Yamagata, K.; Watanabe, Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 1995, 697, 187-196.
21. Chen, Z.; Jalabi, W.; Shpargel, K.B.; Farabaugh, K.T.; Dutta, R.; Yin, X.; Kidd, G.J.; Bergmann, C.C.; Stohlman, S.A.; Trapp, B.D. Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J. Neurosci. 2012, 32, 11706-11715.
22. O'Connor, J.C.; Lawson, M.A.; André, C.; Moreau, M.; Lestage, J.; Castanon, N.; Kelley, K.W.; Dantzer, R. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatr. 2009, 14, 511-522.
23. Noble, F.; Rubira, E.; Boulanouar, M.; Palmier, B.; Plotkine, M.; Warnet, J.-M.; Marchand-Leroux, C.; Massicot, F. Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice. Neurosci. Lett. 2007, 424, 106-110.
24. Shaw, K.N.; Commins, S.; O'Mara, S.M. Lipopolysaccharide causes deficits in spatial learning in the water maze but not in BDNF expression in the rat dentate gyrus. Behav. Brain Res. 2001, 124, 47-54.
25. Kreutzberg, G.W. Microglia: A sensor for pathological events in the CNS. Trends Neurosci. 1996, 19, 312-318.
26. Vila, M.; Jackson-Lewis, V.; Guégan, C.; Wu, D.C.; Teismann, P.; Choi, D.K.; Tieu, K.; Przedborski, S. The role of glial cells in Parkinson's disease. Curr. Opin. Neurol. 2001, 14, 483-489.
27. Teismann, P.; Schulz, J.B. Cellular pathology of Parkinson's disease: Astrocytes, microglia and inflammation. Cell Tissue Res. 2004, 318, 149-161.
28. Okuyama, S.; Minami, S.; Shimada, N.; Makihata, N.; Nakajima, M.; Furukawa, Y. Anti-inflammatory and neuroprotective effect of auraptene, a citrus coumarin, following cerebral global ischemia in mice. Eur. J. Pharm. 2013, 699, 118-123.
29. Chung, D.W.; Yoo, K.-Y.; Hwang, I.K.; Kim, D.W.; Chung, J.Y.; Lee, C.H.; Choi, J.H.; Choi, S.Y.; Youn, H.Y.; Lee, I.S. et al. Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cell Mol. Neurobiol. 2010, 30, 531-541.
30. Farina, C.; Aloisi, F.; Meinl, E. Astrocytes are active players in cerebral innate immunity. Trends Immunol. 2007, 28, 138-145.
31. Yirmiya, R. Endotoxin produces a depressive-like episode in rats. Brain Res. 1996, 711, 163-174.
32. Frenois, F.; Moreau, M.; O'Connor, J.; Lawson, M.; Micon, C.; Lestage, J.; Kelley, K.W.; Dantzer, R.; Castanon, N. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 2007, 32, 516-531.
33. Cerda, B.; Thomas-Barberan, F.A.; Espin, J.C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: Identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227-235.
34. Ito, H.; Iguchi, A.; Hatano, T. Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats. J. Agric. Food Chem. 2008, 56, 393-400.
35. Giménez-Bastida, J.A.; Larrosa, M.; González-Sarrías, A.; Tomás-Barberán, F.; Espín, J.C.; García-Conesa, M.T. Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts. J. Agric. Food Chem. 2012, 60, 8866-8876.
36. Townsend, K.P.; Praticò, D. Novel therapeutic opportunities for Alzheimer's disease: Focus on nonsteroidal anti-inflammatory drugs. FASEB J. 2005, 19, 1592-1601.
37. Okuyama, S.; Shimada, N.; Kaji, M.; Morita, M.; Miyoshi, K.; Minami, S.; Amakura, Y.; Yoshimura, M.; Yoshida, T.; Watanabe, S.; Nakajima, M.; Furukawa, Y. Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice. Neurosci. Lett. 2012, 528, 190-195.