Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma

Journal of Cellular Biochemistry

Volumn 114, Issue 7, 2013, Pages 1595-1605

  Ge, Xiahui ^a,b   Bai, Chong ^a   Yang, Jianming ^a   Lou, Guoliang ^a   Li, Qiang ^a   Chen, Ruohua ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

AIRWAY INFLAMMATION; AIRWAY REMODELING; ASTHMA; BONE MARROW DERIVED MESENCHYMAL STEM CELLS

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4;

AIRWAY REMODELING; ANIMAL MODEL; ARTICLE; ASTHMA; BONE MARROW CELL; CD4+ CD25+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; MESENCHYMAL STEM CELL; MORPHOMETRICS; MOUSE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; TH1 CELL; TH2 CELL; UPREGULATION;

AIRWAY REMODELING; ANIMALS; ASTHMA; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-13; INTERLEUKIN-4; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, REGULATORY;

EID: 84877689091     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24501     Document Type: Article

References (33)

1. Aggarwal S, Pittenger MF,. 2005. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105: 1815-1822. (Pubitemid 40223708)
2. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G,. 2007. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 56: 1175-1186. (Pubitemid 46608642)
3. Beasley R,. 2004. The Global Burden of Asthma Report; Global Initiative for Asthma (GINA). Available from http://www.ginasthma.org
4. Bonifield TL, Koloze M, Lennon DP, Zuchowski B, Ya SE,. 2010. Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol 299: 760-770.
5. Boudousquié C, Longaretti C, Barbier N, Spertini F,. 2006. Regulatory role of CD4 + CD25 + T cells in the antigen specific induction of tolerance in a murine model of asthma. J Allergy Clin Immun 2: 242.
6. Clark THJ,. 1990. Action asthma. The occurrence and costs of asthma. West Sussex, United Kingdom: Cambridge Medical Publications.
7. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A,. 2006. Human mesenchymal stem cells modulate B-cell functions. Blood 107: 367-372. (Pubitemid 43053565)
8. Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA,. 1999. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immun 162: 6233-6237. (Pubitemid 29314987)
9. Ford JG, Rennick D, Donaldson DD, Venkayya R, McArthur C, Hansell E, Kurup VP, Warnock M, Grünig G,. 2001. IL-13 and IFN-gamma: Interactions in lung inflammation. J Immunol 167: 1769-1777. (Pubitemid 32703181)
10. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA,. 2007. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179: 1855-1863.
11. Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, Mao N,. 2005. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105: 4120-4126. (Pubitemid 40656164)
12. Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, Dazzi F,. 2003. Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide. Blood 101: 3722-3729. (Pubitemid 36857965)
13. Lee RH, Seo MJ, Reger RL, Spees JL, Pulin AA, Olson SD, Prockop DJ,. 2006. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NODscid mice. Proc Natl Acad Sci USA 103: 17438-17443. (Pubitemid 44788987)
14. Lee SH, Jang AS, Kwon JH, Park SK, Won JH, Park CS,. 2011. Mesenchymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murine asthma model. Allergy Asthma Immunol Res 3: 205-211.
15. Maccario R, Podestà M, Moretta A, Cometa A, Comoli P, Montagna D, Daudt L, Ibatici A, Piaggio G, Pozzi S, Frassoni F, Locatelli F,. 2005. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T cell subsets expressing a regulatory/suppressive phenotype. Haematologica 90: 516-525. (Pubitemid 40592895)
16. Masoli M, Fabian D, Holt S, Beasley R,. 2004. The global burden of asthma: Executive summary of the GINA Dissemination Committee Report. Allergy 59: 469-478. (Pubitemid 38580764)
17. Matsuse H, Kong X, Hu J, Wolf SF, Lockey RF,. 2003. Intranasal IL-12 produces discreet pulmonary and systemic effects on allergic inflammation and airway reactivity. Int Immunopharmacol 3: 457-468. (Pubitemid 36419507)
18. Naseer T, Minshall EM, Leung DY, Laberge S, Ernst P, Martin RJ, Hamid Q,. 1997. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med 155: 845-851. (Pubitemid 27133392)
19. Onari Y, Yokoyama A, Haruta Y, Nakashima T, Iwamoto H, Hattori N, Kohno N,. 2009. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure. Clin Exp Allergy 39: 290-298.
20. Ortiz LA, Treil MD, Fattman C, Pandey AC, Torres G, Go K, Phinney DG,. 2007. Interleukin 1 receptor antagonist mediates the anti-inflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104: 11002-11007. (Pubitemid 47175216)
21. Phinney DG,. 2008. Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion. In:, Prockop DJ, Phinney DG, Bunnell BA, editors. Mesenchymal stem cells: Method and protocols. New Jersey: Human press. C pp P171-P186.
22. Rasmusson I, Ringden O, Sundberg B, Le Blanc K,. 2003. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 76: 1208-1213. (Pubitemid 37339646)
23. Selmani Z, Naji A, Zidi I, Favier B, Gaiffe E, Obert L, Borg C, Saas P, Tiberghien P, Rouas-Freiss N, Carosella ED, Deschaseaux F,. 2008. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4 + CD25 high FOXP3 + regulatory T cells. Stem Cells 26: 212-222.
24. Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L,. 2006. Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 107: 1484-1490. (Pubitemid 43242385)
25. Temelkovski J, Hogan SP, Shepherd DP, Foster P, Kumar R,. 1998. An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 53: 849-856. (Pubitemid 28459541)
26. Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt MC, Gundel R, Gelfand EW,. 2001. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immun 166: 5792-5800. (Pubitemid 32374206)
27. Uccelli A, Moretta L, Pistoia V,. 2006. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 36: 2566-2573. (Pubitemid 44608440)
28. Weinstein MC, Stason WB,. 1977. Foundations of cost-effectiveness analysis for health and medical practices. New Engl J Med 296: 716-721. (Pubitemid 8066534)
29. Weiss KB, Sullivan SD,. 1993. The economic costs of asthma: A review and conceptual model. Pharmacoeconomics 4: 14-30.
30. Weiss KB, Gergen PJ, Hodgson TA,. 1992. An economic evaluation of asthma in the United States. New Engl J Med 327: 571-572.
31. Xie Z, Ma X, Ji W, Zhou G, Lu Y, Xiang Z, Wang YX, Zhang L, Hu Y, Ding YQ, Zhang WJ,. 2010. Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus. Proc Natl Acad Sci USA 107: 6510-6515.
32. Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M,. 2007. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol-Lung C 293: 131-141.
33. Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, Giunti D, Ceravolo A, Cazzanti F, Frassoni F, Mancardi G, Uccelli A,. 2005. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T cell anergy. Blood 106: 1755-1761. (Pubitemid 41208591)