Hiwi knockdown inhibits the growth of lung cancer in nude mice

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 2, 2013, Pages 1067-1072

  Liang, Dong ^a   Dong, Min ^b   Hu, Lin Jie ^a   Fang, Ze Hui ^b   Xu, Xia ^a   Shi, En Hui ^c   Yang, Yi Ju ^a  

^a Hainan Province Nongken Sanya Hospital   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c Anorectal Department of the Central Hospital of Jiamusi City   (China)

Author keywords

Hiwi gene; Lung cancer stem cell; RNA interference; shRNA

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; ARGONAUTE PROTEIN; ISOENZYME; PIWIL1 PROTEIN, HUMAN; RETINAL DEHYDROGENASE; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER STEM CELL; CANCER TRANSPLANTATION; CELL PROLIFERATION; DRUG SCREENING; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; ARGONAUTE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; GENETIC THERAPY; HUMANS; ISOENZYMES; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; RETINAL DEHYDROGENASE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84877684031     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.2.1067     Document Type: Article

References (26)

1. Chong SS, Hu P, Hernandez N (2001). Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex. J Biol Chem, 276, 20727-34.
2. Cioca DP, Aoki Y, Kiyosawa K (2003). RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines. Cancer Gene Ther, 10, 125-33.
3. Clarke, MF, Dick, JE, Dirks, PB, et al (2006). Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res, 66, 9339-44.
4. Cox DN, Chao A, Baker J, et al (1998). A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev, 12, 3715-27.
5. Duxbury MS, Ito H, Zinner MJ, et al (2004). Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery, 135, 555-62.
6. Eramo A, Lotti F, Sette G, et al (2008). Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ, 15, 504-14.
7. Filleur S, Courtin A, Ait-Si-Ali S, et al (2003). SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res, 63, 3919-22.
8. Grochola LF, Greither T, Taubert H, et al (2008). The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer, 99, 1083-8.
9. Gurzov EN, Izquierdo M (2006). RNA interference against Hec1 inhibits tumor growth in vivo. Gene Ther, 13, 1-7.
10. Hu-Lieskovan S, Heidel JD, Bartlett DW, et al (2005). Sequencespecific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res, 65, 8984-92.
11. Hutvagner G, Simard MJ (2008). Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol, 9, 22-32.
12. Liang D, Fang Z, Dong M, et al (2012). Effect of RNA interferencerelated HiWi gene expression on the proliferation and apoptosis of lung cancer stem cells. Oncol Lett, 4, 146-50.
13. Liang D, Shi Y (2012). Aldehyde dehydrogenase-1 is a specific marker for stem cells in human lung adenocarcinoma. Med Oncol, 29, 633-9.
14. Li K, Lin SY, Brunicardi FC, Seu, P (2003). Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res, 63, 3593-7.
15. Liu X, Sun Y, Guo J, et al (2006). Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer, 118, 1922-9.
16. Nakahira S, Nakamori S, Tsujie M, et al (2007). Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer, 120, 1355-63.
17. Paul CP, Good PD, Winer I, Engelke DR (2002). Effective expression of small interfering RNA in human cells. Nat Biotechnol, 20, 505-8.
18. Scherr M, Battmer K, Winkler T, et al (2003). Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood, 101, 1566-9.
19. Sharma AK, Nelson MC, Brandt JE, et al (2001). Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood, 97, 426-34.
20. Siddiqi S, Terry M, Matushansky I (2012). Hiwi mediated tumorigenesis is associated with DNA hypermethylation. PLoS One, 7, e33711.
21. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29.
22. Takei Y, Kadomatsu K, Yuzawa Y, et al (2004). A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res, 64, 3365-70.
23. Taubert H, Greither T, Kaushal D, et al (2007). Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene, 26, 1098-100.
24. Visvader JE, Lindeman GJ (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer, 8, 755-68.
25. Yu YT, Maroney PA, Darzynkiwicz E, Nilsen TW (1995). U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone. RNA, 1, 46-54.
26. Zamore PD, Tuschl T, Sharp PA, Bartel DP (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101, 25-33.