AntagomiR-27a targets FOXO3a in glioblastoma and suppresses U87 cell growth in vitro and in vivo

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 2, 2013, Pages 963-968

  Ge, Yun Fei ^a   Sun, Jun ^a   Jin, Chun Jie ^b   Cao, Bo Qiang ^a   Jiang, Zhi Feng ^c   Shao, Jun Fei ^a  

^a WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

^b Beichen Hospital   (China)

^c JIANGYIN PEOPLE S HOSPITAL   (China)

Author keywords

AntagomiR 27a; Glioblastoma; MiR 27a; Target gene FOXO3a

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; MICRORNA; MIRN27 MICRORNA, HUMAN; OLIGONUCLEOTIDE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL PROLIFERATION; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; GLIOBLASTOMA; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84877648915     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.2.963     Document Type: Article

References (20)

1. Arden KC (2007). FoxOs in tumor suppression and stem cell maintenance. Cell, 128, 235-7.
2. Burgess R, Jenkins R, Zhang Z (2008). Epigenetic changes in gliomas. Cancer Biol Ther, 7, 1326-34.
3. Castrillon DH, Miao I, Kollipara R,et al (2003). Suppression of ovarian folic leactivation in mice by the transcription fator Foxo3a. Science, 301, 215-8.
4. Cummins JM, He Y, Leary RJ,et al ( 2006). The colorectal microRNAome. Proc Natl Acad Sci USA, 103, 3687-92.
5. Greer EL, Brunet A (2005). FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24, 7410-25.
6. Hu MC, Lee DF, Xia W,et al (2004). IkappaB kinase promotes tumor genesis throug h inhibition of forkhead FOXO3a. Cell, 11, 225-37.
7. Lee CC, Putnam AJ, Miranti CK, et a1 (2004). Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Oncogene, 23, 5193-202.
8. Li X, Mertens-Talcott S U, Zhang S,et al (2010). MicroRNA- 27a indirectly regulates estrogen receptor {alpha} expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology, 151, 2462-73.
9. Lim J, Wong ES, Ong SH, et a1 (2000). Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation: Identification of a novel translocation domain. J Bio1 Chem, 275, 32837-45.
10. Liu T, Tang H, Lang Y,et al (2009). MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer Lett, 273, 233-42.
11. Ma Y, Yu S, Zhao W,et al (2010). miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2. Cancer Lett, 298, 150-8.
12. Mourelatos Z, Dostie J, Paushkin S,et al (2002). miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev, 16, 720-8.
13. Paik JH, Kollipara R Chu G, et al (2007). FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell, 128, 309-23
14. Papagiannakopoulos T, Shapiro A, Kosik KS (2008). MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res, 68, 8164-72.
15. Seoane J, Le HV, Shen L, et a1 (2004). Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell, 117, 211-23
16. Sevignani C, Calin GA, Siracusa LD,et al (2006). Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome, 17, 189-202.
17. Wang Q, Li DC, Li ZF,et al (2011). Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen. Oncogene, 30, 3875-86.
18. Yamamura Y, Lee W L, Inoue K,et al (2006). RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem, 281, 5267-76.
19. Yigzaw Y, Poppleton HM, Sreejayan N, et a1 (2003). Protein- tyrosine phosphatase-1 B(PTP 1 B)mediates the anti-migratory actions of Sprouty. J Bio1 Chem, 278, 284-8.
20. Yigzaw Y, Cartin L, Pierre S, et a1 (2001). The C terminus of sprouty is important for modulation of cellular migration and proliferation. J Bio1 Chem, 276, 22742-7.