Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: Tissue, matrix and mechanistic insights

Journal of Urology

Volumn 189, Issue 6, 2013, Pages 2377-2384

  Schröder, Annette ^a,b   Kirwan, Tyler P ^b   Jiang, Jia Xin ^b   Aitken, Karen J ^b   Bägli, Darius J ^c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

mTOR protein rat; muscle smooth; sirolimus; urinary bladder; urinary bladder neck obstruction

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 3 ALPHA 1; COLLAGEN TYPE I ALPHA 1; ELASTIN; MATRILYSIN; MESSENGER RNA; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BLADDER MUSCLE; BLADDER NECK STENOSIS; BODY WEIGHT; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; MICTURITION; MUSCLE HYPERTROPHY; NONHUMAN; POSTVOID RESIDUAL URINE VOLUME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BIOPSY, NEEDLE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; MUSCLE HYPERTONIA; MUSCLE, SMOOTH; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TREATMENT OUTCOME; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION;

EID: 84877615884     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.12.110     Document Type: Article

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