Development of intravenous lipid emulsion of α-asarone with significantly improved safety and enhanced efficacy

International Journal of Pharmaceutics

Volumn 450, Issue 1-2, 2013, Pages 21-30

  Ma, Wei Cong ^a   Zhang, Qing ^a   Li, Hui ^b,c   Larregieu, Caroline A ^d   Zhang, Na ^a   Chu, Ting ^a   Jin, Hui ^a   Mao, Sheng Jun ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asarone; Asthma treatment; Formulation optimization; Lipid emulsion; Safety evaluation

Indexed keywords

ALPHA ASARONE; LIPID EMULSION; SOYBEAN OIL;

ACUTE TOXICITY; ALLERGY TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG STABILITY; DRUG STORAGE; ENCAPSULATION; GUINEA PIG; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INJECTION SITE IRRITATION; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; THERMOSTABILITY; ZETA POTENTIAL;

ANIMALS; ANISOLES; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DRUG HYPERSENSITIVITY; DRUG STABILITY; EAR; EMULSIONS; FEMALE; GUINEA PIGS; INJECTIONS, INTRAVENOUS; LECITHINS; MALE; MICE; POLYETHYLENE GLYCOLS; PROPYLENE GLYCOLS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SOYBEAN OIL; TOXICITY TESTS, ACUTE; VEINS;

EID: 84877606092     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.04.023     Document Type: Article

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