Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade

Phytotherapy Research

Volumn 20, Issue 12, 2006, Pages 1080-1084

  Gilani, Anwar Ul Hassan ^a   Shah, Abdul Jabbar ^a   Ahmad, Manzoor ^b   Shaheen, Farzana ^b  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Acorus calamus; Antispasmodic; Calcium channel blocker

Indexed keywords

ACETIC ACID ETHYL ESTER; ACORUS CALAMUS EXTRACT; ALKALOID; CALCIUM CHANNEL; HEXANE; SAPONIN; TANNIN; VERAPAMIL;

ACORUS CALAMUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; FRACTIONATION; JEJUNUM; MOUSE; NONHUMAN; RABBIT; RECEPTOR BLOCKING; SMOOTH MUSCLE CONTRACTION; SPASMOLYSIS;

ACORUS; ACUTE TOXICITY TESTS; ANIMALS; ANTIDIARRHEALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; FEMALE; INHIBITORY CONCENTRATION 50; JEJUNUM; MALE; MICE; MUSCLE CONTRACTION; PARASYMPATHOLYTICS; PLANT EXTRACTS; RABBITS; VERAPAMIL;

ACORUS CALAMUS; ARACEAE; ORYCTOLAGUS CUNICULUS;

EID: 33845633874     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2000     Document Type: Article

References (35)

1. Acuna UM, Atha DE, Ma J, Nee MH, Kennelly EJ. 2002. Antioxidant capacities of ten edible North American plants. Phytother Res 16: 63-65.
2. Baquar SR. 1989. Medicinal and Poisonous Plants of Pakistan. Printas: Karachi, 9-10.
3. Bolton TB. 1979. Mechanism of action of transmitters and other substances on smooth muscles. Physiol Rev 59: 606-718.
4. Brading AF. 1981. How do drugs initiate contraction in smooth muscles? Trends Pharmacol Sci 2: 261-265.
5. Brunton LL. 1996. Agents affecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes. In Goodman and Gillman's The Pharmacological Basis of Therapeutics, Hardman JG, Limbird LE, Molinoff PB (eds). McGraw Hill: New York, 917-936.
6. Chevallier A. 1996. The Encyclopedia of Medicinal Plants. Dorling Kindersley: London.
7. Dandiya PC, Cullumbine H. 1959. Studies on Acorus calamus III. Some pharmacological actions of the volatile oil. J Pharmacol Exp Ther 125: 353-359.
8. Danilevskii NF, Antonishin BV. 1982. Antimicrobial activity of a tincture of Japanese pagoda tree (Sophora japonica) and of the essential oil of sweet flag (Acorus calamus). Mikrobiol Zh 44: 80-82.
9. Das PK, Malhotra CL, Dhalla NS. 1962. Spasmolytic activity of asarone and essential oil of Acorus calamus, Linn. Arch Int Pharmacodyn Ther 135: 167-177.
10. Duke JA. 2002. Handbook of Medicinal Herbs. CRC Press: Boca Raton, FL.
11. Duke JA, Ayensu ES. 1985. Medicinal Plants of China. Dorling Kindersley: London.
12. Edeoga HO, Okwu KE, Mbaebie BO. 2005. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 4: 685-688.
13. ++ antagonists. Gen Pharmacol 22: 177-181.
14. ++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol 17: 149-166.
15. Gilani AH, Abdul JS, Muhammad NG, Kashif M. 2005. Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci 76: 3089-3105.
16. Gilani AH, Aziz N, Khan MA et al. 2000. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas. J Ethnopharmacol 71: 161-171.
17. ++ channel blocking activity of Artemisia scoparia extract. Phytother Res 8: 161-165.
18. Gilani AH, Shaheen F, Zaman M, Janbaz KH, Shah BH, Akhtar MS. 1999. Studies on antihypertensive and antispasmodic activities of methanolic extract of Acacia nilotica. Phytother Res 13: 665-669.
19. Godfraind T, Miller R, Wibo M. 1986. Calcium antagonism and calcium entry blockade. Pharmacol Rev 38: 321-416.
20. Gricilda FS, Thomas M. 2001. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 76: 73-76.
21. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG. 1964. Food flavouring and compounds of related structure I. Acute oral toxicity. Food Cosmet Toxicol 2: 327-343.
22. Kapoor LD. 1990. Handbook of Ayurvedic Medicinal Plants. CRC Press: Boca Raton, FL, 18-19.
23. Karaki H, Weiss G. 1983. Mini-review: Calcium release in smooth muscles. Life Sci 42: 111-122.
24. Menon MK, Dandiya PC. 1967. The mechanism of the tranquillizing action of asarone from Acorus calamus Linn. J Pharm Pharmacol 19: 170-175.
25. National Research Council. 1996. Guide for the Care and Use of Laboratory Animals. National Academy Press: Washington, DC.
26. Oh MH, Houghton PJ, Whang WK, Cho JH. 2004. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 11: 544-548.
27. Parab RS, Mengi SA. 2002. Hypolipidemic activity of Acorus calamus L. in rats. Fitoterapia 73: 451-455.
28. Satyavati, GV, Raina MK, Sharma M. 1976. Medicinal Plants of India, vol. 1. Indian Council of Medical Research: New Dehli, 19.
29. Shukla PK, Khanna VK, Ali MM, Maurya RR, Handa SS, Srimal RC. 2002. Protective effect of Acorus calamus against acrylamide induced neurotoxicity. Phytother Res 16: 256-260.
30. Usher G. 1974. A Dictionary of Plants Used by Man. Constable: London.
31. Usmanghani K, Saeed A, Alam MT. 1997. Indusyunic Medicine. University of Karachi Press: Karachi, 87-88.
32. Van-Rossum JM. 1963. Cumulative dose-response curves. II. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn 143: 299-330.
33. Wallis TE. 1985. Textbook of Pharmacognosy, 5th edn. CBS Publishers & Distributors: New Delhi, 396-397.
34. Weiner MA. 1980. Earth Medicine, Earth Food. Ballantine Books: New York.
35. Williamson EM, Okpako DT, Evans FJ. 1998. Pharmacological Methods in Phytotherapy Research. John Wiley & Sons: Chichester, 15-23.