Development of drug-in-adhesive transdermal patch for α-asarone and in vivo pharmacokinetics and efficacy evaluation

Drug Delivery

Volumn 18, Issue 1, 2011, Pages 84-89

  Hu, Ying ^a,b   Wu, Yao Yao ^b   Xia, Xiao Jing ^a   Wu, Zheng ^b   Liang, Wen Quan ^b   Gao, Jian Qing ^b  

^a Zhejiang Pharmaceutical College   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Asarone; Asthma treatment.; Penetration enhancers; Pharmacokinetics; Transdermal drug delivery system

Indexed keywords

ALPHA ASARONE; DEXAMETHASONE; EUDRAGIT; MYRISTIC ACID ISOPROPYL ESTER; OLEIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG SCREENING; IN VIVO STUDY; LUNG LAVAGE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SKIN PERMEABILITY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSDERMAL PATCH;

ACRYLATES; ADHESIVES; ANIMALS; ANISOLES; ASTHMA; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG SYNERGISM; INFLAMMATION; MYRISTATES; OLEIC ACID; PERMEABILITY; POLYMERS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; TRANSDERMAL PATCH;

EID: 78650098308     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2010.520350     Document Type: Article

References (15)

1. Arora, P., Mukherjee, B. (2002). Design, development, physicochemi-cal, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. J Pharm Sci. 91:2076-89.
2. Asher, M.I., Montefort, S., Bjorksten, B., Lai, C.K., Strachan, D.P., Weiland, S.K., Williams, H. (2006). Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lance. 368:733-43.
3. Cochrane M.G., Bala, M.V., Downs, K.E., Mauskopf, J., Ben-Joseph, R.H. (2000). Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique. Chest. 117:542-50.
4. Cui, Y., Frank, S.G. (2006). Characterization of supersaturated lido-cain/polyacrylate pressure sensitive systems:thermal analysisi and FT-IR. J Pharm Sci. 95:701-13
5. Hadgraft, J. (1999). Passive enhancement strategies in topical and transdermal drug delivery. Int J Pharm. 184:1-6.
6. Ji, W., Chen, X., Zhengrong, C., Yumin, H., Huang, L., Qiu Y. (2008). Terapeutic efects of anti-B7-1 antibody in an ovalbumin-in-duced mouse asthma model. Int Immunopharmacol. 8:1190-5.
7. Kakubari, I., Shinkai, N., Kawakami, J., Uruno, A., Takayasu, T., Yamauchi, H. (2006). Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate. Biol Pharm Bull. 29:513-6.
8. Larrucea, E., Arellano, A., Santoyo, S., Ygartua, P. (2001). Combined efect of oleic acid and propylene glycol on the percutaneous penetration of tenoxicam and its retention in the skin. Eur J Pharm Biopharm. 52:113-9.
9. Lee, C.M., Chang, J.H., Moon, D.O., Choi, Y.H., Choi, I.W., Park, Y.M., Kim, G.Y. (2008). Lycopene suppresses ovalbumin-induced airway infammation in a murine model of asthma. Biochem Biophys Res Commun. 374:248-52.
10. Levison, K., Takayama, K., Isowa, K., Okabe, K., Nagai, T. (1994). Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers. J Pharm Sci. 83:1367-72.
11. Manikandan, S., Devi, R.S. (2005). Antioxidant property of α-asarone against noise-stress-induced changes in diferent regions of rat brain. Pharmacol Res. 52:467-74.
12. Merkle, H.P. (1989). Transdermal delivery systems. Methods Find Exp Clin Pharmacol. 11:135-53.
13. O'Byrne, P.M., Inman, M.D. (2000). New considerations about measuring airway hyperresponsiveness. J Asthma. 37:293-302.
14. Wu, Y. (2003). Study on the bioavailability of α-asarone tablets. China Clin Hosp Pharm J. 23:597-8.
15. Zhao, K., Singh, J. (1999). In vitro percutaneous absorption enhancement of propranolol hydrochloride through porcine epidermis by terpenes/ethaol. J Contr Rel. 62:359-66.