Pin1 Null Mice Exhibit Low Bone Mass and Attenuation of BMP Signaling

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Shen, Zhong Jian ^a   Hu, Jie ^a   Ali, Aktar ^a   Pastor, Johanne ^a   Shiizaki, Kazuhiro ^a   Blank, Robert D ^b   Kuro o, Makoto ^a   Malter, James S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; CALCIUM ION; COLLAGEN TYPE 1; ISOMERASE; PEPTIDYLPROLYL ISOMERASE PIN1; SMAD5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OSX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; CONTROLLED STUDY; CORTICAL BONE; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; OSTEOBLAST; OSTEOCLAST ACTIVITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRABECULAR BONE;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEINS; CALCIUM; CELL DIFFERENTIATION; CHOLECALCIFEROL; GENE EXPRESSION; MICE; MICE, KNOCKOUT; OSTEOCLASTS; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD5 PROTEIN;

EID: 84877601696     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063565     Document Type: Article

References (23)

1. Reginster JY, Burlet N, (2006) Osteoporosis: a still increasing prevalence. Bone. 38: S4-9.
2. Caetano-Lopes J, Canhão H, Fonseca JE, (2007) Osteoblasts and bone formation. Acta Reumatol Port. 32: 103-10.
3. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107: 513-23.
4. Lin GL, Hankenson KD, (2011) Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem. 112: 3491-501.
5. Lee TH, Pastorino L, Lu KP, (2011) Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Rev Mol Med. Jun 20 13: e21.
6. Shen ZJ, Esnault S, Malter JS, (2005) The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils. Nat Immunol. 6: 1280-87.
7. Shen ZJ, Esnault S, Rosenthal LA, Szakaly RJ, Sorkness RL, et al. (2008) Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. J Clin Invest. 118: 479-90.
8. Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS, (2009) The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol 10: 257-65.
9. Nechama M, Uchida T, Yosef-Levi IM, Silver J, Naveh-Many T, (2009) The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. J Clin Invest. 119: 3102-14.
10. Rajbhandari P, Finn G, Solodin NM, Singarapu KK, Sahu SC, et al. (2012) Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Mol Cell Biol. 32 (2): 445-57.
11. Yi P, Wu RC, Sandquist J, Wong J, Tsai SY, et al. (2005) Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 25 (21): 9687-99.
12. Shen ZJ, Nakamoto T, Tsuji K, Nifuji A, Miyazono K, et al. (2002) Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J Biol Chem. 277: 29840-46.
13. Morinobu M, Nakamoto T, Hino K, Tsuji K, Shen ZJ, et al. (2005) The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J Exp Med. 201: 961-70.
14. Bakker AD, Klein-Nulend J, (2012) Osteoblast isolation from murine calvaria and long bones. Methods Mol Biol. 816: 19-29.
15. Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, et al. (2002) Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes Proc Natl Acad Sci USA. 99: 1335-40.
16. Zheng H, You H, Zhou XZ, Murray SA, Uchida T, et al. (2002) The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 419: 849-53.
17. Uchida K, Urabe K, Naruse K, Kozai Y, Onuma K, et al. (2012) Differential age-related bone architecture changes between female and male STR/Ort mice. Exp Anim. 61: 59-66.
18. Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 221: 249-58.
19. Mishina Y, Suzuki A, Ueno N, Behringer RR, (1995) Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9: 3027-37.
20. Matsuura I, Chiang KN, Lai CY, He D, Wang G, et al. (2010) Pin1 promotes transforming growth factor-beta-induced migration and invasion. J Biol Chem. 285: 1754-64.
21. Shen ZJ, Braun RK, Hu J, Xie Q, Chu H, et al. (2012) Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem. 287: 23294-305.
22. Massagué J, Wotton D, (2000) Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 19: 1745-54.
23. Christoulas D, Terpos E, Dimopoulos MA, (2009) Pathogenesis and management of myeloma bone disease. Expert Rev Hematol. 2: 385-98.