Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells

Biochemical Pharmacology

Volumn 82, Issue 4, 2011, Pages 418-425

  Wei, Qiang ^a,b   Costanzi, Stefano ^a   Liu, Qiu Zhen ^c   Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Apoptosis; GPCR; Nucleotide; P2Y1 receptor; Prostate cancer

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (2 IODO 6 METHYLAMINO 9H PURIN 9 YL) 2 PHOSPHONOOXYBICYCLO[3.1.0]HEXANE 1 METHANOL; CASPASE 3; CYCLOHEXIMIDE; G PROTEIN COUPLED RECEPTOR; LACTATE DEHYDROGENASE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MRS 2365; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2 IODO N(6) METHYL (N) METHANOCARBA 2' DEOXYADENOSINE 3',5' BISPHOSPHATE; 2-IODO-N(6)-METHYL-(N)-METHANOCARBA-2'-DEOXYADENOSINE-3',5'-BISPHOSPHATE; DEOXYADENOSINE PHOSPHATE; GROWTH INHIBITOR; PURINERGIC P2Y RECEPTOR AGONIST; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSTATE CARCINOMA; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; COMPARATIVE STUDY; DRUG EFFECT; GENE TARGETING; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYADENINE NUCLEOTIDES; GENE TARGETING; GROWTH INHIBITORS; HUMANS; MALE; PROSTATIC NEOPLASMS; PURINERGIC P2Y RECEPTOR AGONISTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2Y1;

EID: 79960367410     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.013     Document Type: Article

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