New insights in endogenous modulation of ligand-gated ion channels: Histamine is an inverse agonist at strychnine sensitive glycine receptors

European Journal of Pharmacology

Volumn 710, Issue 1-3, 2013, Pages 59-66

  Kletke, Olaf ^b   Sergeeva, Olga A ^b   Lorenz, Philipp ^a   Oberland, Sonja ^d,e   Meier, Jochen C ^c   Hatt, Hanns ^a   Gisselmann, Günter ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Competitive antagonist; Endogenous modulator; Glycine; Histamine; Ligand gated ion channel; Modulation

Indexed keywords

ALPHA1 GLYCINE RECEPTOR; ALPHA1BETA GLYCINE RECEPTOR; ALPHA2 GLYCINE RECEPTOR; ALPHA2BETA GLYCINE RECEPTOR; ALPHA3BETA GLYCINE RECEPTOR; GLYCINE; GLYCINE RECEPTOR; HISTAMINE; LIGAND GATED ION CHANNEL; RECEPTOR SUBUNIT; STRYCHNINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN NERVE CELL; CONCENTRATION RESPONSE; ELECTRODE; HUMAN; HYPOTHALAMUS; MOUSE; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; DNA, COMPLEMENTARY; HISTAMINE; HUMANS; HYPOTHALAMUS; MALE; MICE, INBRED C57BL; NEURONS; OOCYTES; PROTEIN SUBUNITS; RATS; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 84877592894     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.04.002     Document Type: Article

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