Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia

Journal of Human Hypertension

Volumn 27, Issue 6, 2013, Pages 349-354

  Sertorio J T ^a   Lacchini, R ^b   Amaral, L M ^b   Palei, A C T ^b   Cavalli, R C ^c   Sandrim, V C ^b   Duarte, G ^c   Tanus Santos, J E ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Núcleo de Pós Graduação e Pesquisa Santa Casa de Belo Horizonte   (Brazil)

Author keywords

haptoglobin; hemoglobin; hemolysis; nitric oxide; polymorphism; preeclampsia

Indexed keywords

HAPTOGLOBIN; NITRIC OXIDE;

ADULT; ARTICLE; BIOAVAILABILITY; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; PHENOTYPE; PREECLAMPSIA; PROTEIN POLYMORPHISM; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; BIOLOGICAL AVAILABILITY; FEMALE; HAPTOGLOBINS; HUMANS; NITRIC OXIDE; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY;

EID: 84877592219     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2012.57     Document Type: Article

References (36)

1. Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997; 272(2 Part 2): R441-R463.
2. Thornburg KL, Jacobson S-L, Giraud GD, Morton MJ. Hemodynamic changes in pregnancy. Semin Perinatol 2000; 24: 11-14.
3. Jim B, Sharma S, Kebede T, Acharya A. Hypertension in pregnancy: a comprehensive update. Cardiol Rev 2010; 18(4): 178-189.
4. Palei AC, Sandrim VC, Cavalli RC, Tanus-Santos JE. Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension. Clin Biochem 2008; 41(10-11): 875-880.
5. Sandrim VC, Montenegro MF, Palei AC, Metzger IF, Sertorio JT, Cavalli RC et al. Increased circulating cell-free hemoglobin levels reduce nitric oxide bioavailability in preeclampsia. Free Radic Biol Med 2010; 49(3): 493-500.
6. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350(7): 672-683.
7. Sankaralingam S, Xu H, Davidge ST. Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. Cardiovasc Res 2010; 85(1): 194-203.
8. Wikstrom AK, Nash P, Eriksson UJ, Olovsson MH. Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia. Am J Obstet Gynecol 2009; 201(6): e591-597 e598.
9. Sandrim VC, Palei AC, Metzger IF, Cavalli RC, Duarte G, Tanus-Santos JE. Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia. Clin Chim Acta 2010; 411(19-20): 1457-1460.
10. Sandrim VC, Palei AC, Cavalli RC, Araujo FM, Ramos ES, Duarte G et al. eNOS haplotypes associated with gestational hypertension or preeclampsia. Pharmacogenomics 2008; 9(10): 1467-1473.
11. Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR et al. Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide 2008; 18(4): 296-302.
12. Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon III RO, Schechter AN et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002; 8(12): 1383-1389.
13. Pacher P, Beckman JS, Liaudet L. Nitric Oxide and Peroxynitrite in Health and Disease. Physiol Rev 2007; 87(1): 315-424.
14. Wagener FA, Eggert A, Boerman OC, Oyen WJ, Verhofstad A, Abraham NG et al. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 2001; 98(6): 1802-1811.
15. Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal 2010; 12(2): 293-304.
16. Bowman BH, Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet 1982; 12(189-261): 453-184.
17. Wejman JC, Hovsepian D, Wall JS, Hainfeld JF, Greer J. Structure and assembly of haptoglobin polymers by electron microscopy. J Mol Biol 1984; 174(2): 343-368.
18. Edwards DH, Griffith TM, Ryley HC, Henderson AH. Haptoglobin-haemoglobin complex in human plasma inhibits endothelium dependent relaxation: evidence that endothelium derived relaxing factor acts as a local autocoid. Cardiovasc Res 1986; 20(8): 549-556.
19. Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD et al. Biological activity of nitric oxide in the plasmatic compartment. Proc Natl Acad Sci USA 2004; 101(31): 11477-11482.
20. Sammour RN, Nakhoul FM, Levy AP, Miller-Lotan R, Nakhoul N, Awad HR et al. Haptoglobin phenotype in women with preeclampsia. Endocrine 2010; 38(2): 303-308.
21. Anonymous. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183(1): S1-S22.
22. Pelletier MM, Kleinbongard P, Ringwood L, Hito R, Hunter CJ, Schechter AN et al. The measurement of blood and plasma nitrite by chemiluminescence: Pitfulls and solution. Free Radic Biol Med 2006.
23. Soejima M, Koda Y. TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2). Clin Chem 2008; 54(11): 1908-1913.
24. Olsson MG, Centlow M, Rutardottir S, Stenfors I, Larsson J, Hosseini-Maaf B et al. Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia. Free Radic Biol Med 2010; 48(2): 284-291.
25. Centlow M, Carninci P, Nemeth K, Mezey E, Brownstein M, Hansson SR. Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes. Fertil Steril 2008; 90(5): 1834-1843.
26. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 2005; 293(13): 1653-1662.
27. Jeffers A, Gladwin MT, Kim-Shapiro DB. Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. Free Radic Biol Med 2006; 41(10): 1557-1565.
28. Asleh R, Marsh S, Shilkrut M, Binah O, Guetta J, Lejbkowicz F et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res 2003; 92(11): 1193-1200.
29. Levy AP, Purushothaman KR, Levy NS, Purushothaman M, Strauss M, Asleh R et al. Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res 2007; 101(1): 106-110.
30. Komori H, Watanabe H, Shuto T, Kodama A, Maeda H, Watanabe K et al. alpha1- acid glycoprotein up-regulates CD163 via TLR4/CD14 pathway: possible protection against hemolysis-induced oxidative stress. J Biol Chem 2012; 287: 30688-30700.
31. Weissgerber TL, Roberts JM, Jeyabalan A, Powers RW, Lee M, Datwyler SA et al. Haptoglobin phenotype, angiogenic factors, and preeclampsia risk. Am J Obstet Gynecol 2012; 206(4): 358 e310-358 e358.
32. Chandra TPT, Vishnupriya S, Venkat Raman R. Haptoglobin polymorphism in pregnancy-induced hypertension. Am J Hum Genet 1991; 49: 130.
33. Kato GJ, Gladwin MT. Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA 2008; 300(22): 2638-2646.
34. Alexander BT, Llinas MT, Kruckeberg WC, Granger JP. L-arginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure. Hypertension 2004; 43(4): 832-836.
35. Ramesar SV, Mackraj I, Gathiram P, Moodley J. Sildenafil citrate improves fetal outcomes in pregnant, L-NAME treated, Sprague-Dawley rats. Eur J Obstet Gynecol Reprod Biol 2010; 149(1): 22-26.
36. George EM, Arany M, Cockrell K, Storm MV, Stec DE, Granger JP. Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol 2011; 301(5): R1495-R1500.