SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

Journal of molecular medicine (Berlin, Germany)

Volumn 91, Issue 3, 2013, Pages 381-393

  Dasgupta, Santanu ^a   Jang, Jin Sung ^b   Shao, Chunbo ^b   Mukhopadhyay, Nitai D ^b   Sokhi, Upneet K ^b   Das, Swadesh K ^b   Brait, Mariana ^b   Talbot, Conover ^b   Yung, Rex C ^b   Begum, Shahnaz ^b   Westra, William H ^b   Hoque, Mohammad Obaidul ^b   Yang, Ping ^b   Yi, Joanne E ^b   Lam, Stephan ^b   Gazdar, Adi F ^b   Fisher, Paul B ^b   Jen, Jin ^b   Sidransky, David ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; SH3GL2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL; DNA METHYLATION; DRUG SCREENING; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOSITY LOSS; HUMAN; LUNG TUMOR; MOUSE; NON SMALL CELL LUNG CANCER; PATHOLOGY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE; TUMOR INVASION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MICE; NEOPLASM INVASIVENESS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84877589367     PISSN: None     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0955-3     Document Type: Article

References (28)

1. 1. M Sato DS Shames AF Gazdar JD Minna 2007 A translational view of the molecular pathogenesis of lung cancer J Thoracic Oncol 2 327 343 10.1097/01.JTO.0000263718.69320.4c Sato M, Shames DS, Gazdar AF, Minna JD (2007) A translational view of the molecular pathogenesis of lung cancer. J Thoracic Oncol 2:327–343
2. 2. http://www.cancer.gov/cancertopics/types/lung. Accessed 7 March 2012
3. 3. J Andrews P Yeh W Pao L Horn 2011 Molecular predictors of response to chemotherapy in non-small cell lung cancer Cancer J 17 104 113 21427554 10.1097/PPO.0b013e318213f3cf 1:CAS:528:DC%2BC3MXmtVKnsLg%3D Andrews J, Yeh P, Pao W, Horn L (2011) Molecular predictors of response to chemotherapy in non-small cell lung cancer. Cancer J 17:104–113
4. 4. S Sun JH Schiller AF Gazdar 2007 Lung cancer in never smokers—a different disease Nature Rev Cancer 7 778 790 10.1038/nrc2190 1:CAS:528:DC%2BD2sXhtVOnsr3J Sun S, Schiller JH, Gazdar AF (2007) Lung cancer in never smokers—a different disease. Nature Rev Cancer 7:778–790
5. 5. S Jonsson M Varella-Garcia YE Miller HJ Wolf T Byers S Braudrick P Kiatsimkul M Lewis TC Kennedy RL Keith 2008 Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer Am J Respir Crit Care Med 177 342 347 17989344 10.1164/rccm.200708-1142OC Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL et al (2008) Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. Am J Respir Crit Care Med 177:342–347
6. 6. G Tonon KK Wong G Maulik C Brennan B Feng Y Zhang DB Khatry A Protopopov MJ You AJ Aguirre 2005 High-resolution genomic profiles of human lung cancer Proc Natl Acad Sci U S A 102 9625 9630 15983384 10.1073/pnas.0504126102 1:CAS:528:DC%2BD2MXmsVaktL0%3D Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ et al (2005) High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A 102:9625–9630
7. 7. M Varella-Garcia L Chen RL Powell FR Hirsch TC Kennedy R Keith YE Miller JD Mitchell WA Franklin 2007 Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer Am J Respir Crit Care Med 6 505 512 10.1164/rccm.200609-1329OC Varella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WA (2007) Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer. Am J Respir Crit Care Med 6:505–512
8. 8. PP Massion Y Zou H Uner P Kiatsimkul HJ Wolf AE Baron T Byers S Jonsson S Lam FR Hirsch 2009 Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer PLoS One 4 e5611 19547694 10.1371/journal.pone.0005611 Massion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR et al (2009) Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS One 4:e5611
9. 9. BA Weir MS Woo G Getz S Perner L Ding R Beroukhim WM Lin MA Province A Kraja LA Johnson 2007 Characterizing the cancer genome in lung adenocarcinoma Nature 450 893 898 17982442 10.1038/nature06358 1:CAS:528:DC%2BD2sXhtl2gsbvM Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA et al (2007) Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893–898
10. 10. WW Lockwood R Chari BP Coe KL Thu C Garnis CA Malloff J Campbell AC Williams D Hwang CQ Zhu 2010 Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma PLoS Med 7 e1000315 20668658 10.1371/journal.pmed.1000315 Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ et al (2010) Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Med 7:e1000315
11. 11. RK Thomas B Weir M Meyerson 2006 Genomic approaches to lung cancer Clin Cancer Res 12 4384s 4391s 16857815 10.1158/1078-0432.CCR-06-0098 1:CAS:528:DC%2BD28XntFSmsbY%3D Thomas RK, Weir B, Meyerson M (2006) Genomic approaches to lung cancer. Clin Cancer Res 12:4384s–4391s
12. 12. S Dasgupta RC Yung WH Westra DA Rini J Brandes D Sidransky 2009 Following mitochondrial footprints through a long mucosal path to lung cancer PLoS One 4 e6533 19657397 10.1371/journal.pone.0006533 Dasgupta S, Yung RC, Westra WH, Rini DA, Brandes J, Sidransky D (2009) Following mitochondrial footprints through a long mucosal path to lung cancer. PLoS One 4:e6533
13. 13. S Dasgupta R Koch WH Westra JA Califano PK Ha D Sidransky WM Koch 2010 Mitochondrial DNA mutation in margins and tumors of recurrent HNSCC patients Can Prev Res 3 1205 1211 10.1158/1940-6207.CAPR-10-0018 1:CAS:528:DC%2BC3cXht1Gju7zM Dasgupta S, Koch R, Westra WH, Califano JA, Ha PK, Sidransky D, Koch WM (2010) Mitochondrial DNA mutation in margins and tumors of recurrent HNSCC patients. Can Prev Res 3:1205–1211
14. 14. S Dasgupta E Soudry N Mukhopadhyay C Shao J Yee S Lam 2011 Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation J Cell Physiol 227 6 2451 2460 10.1002/jcp.22980 Dasgupta S, Soudry E, Mukhopadhyay N, Shao C, Yee J, Lam S et al (2011) Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. J Cell Physiol 227(6):2451–2460
15. 15. S Dasgupta M Bhattacharya-Chatterjee BW O’Malley Jr SK Chatterjee 2004 Reversal of immune suppression following vaccination with recombinant vaccinia virus expressing IL-2 in an orthotopic murine model of head and neck squamous cell carcinoma Cancer Therapy 2 375 388 Dasgupta S, Bhattacharya-Chatterjee M, O’Malley BW Jr, Chatterjee SK (2004) Reversal of immune suppression following vaccination with recombinant vaccinia virus expressing IL-2 in an orthotopic murine model of head and neck squamous cell carcinoma. Cancer Therapy 2:375–388
16. 16. S Dasgupta MO Hoque S Upadhyay D Sidransky 2008 Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer Cancer Res 68 700 706 18245469 10.1158/0008-5472.CAN-07-5532 1:CAS:528:DC%2BD1cXhtlygs7w%3D Dasgupta S, Hoque MO, Upadhyay S, Sidransky D (2008) Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. Cancer Res 68:700–706
17. 17. I Szymkiewicz K Kowanetz P Soubeyran A Dinarina S Lipkowitz I Dikic 2002 CIN85 participates in Cb-1-b down-regulation of receptor tyrosine kinases J Biochem 277 39666 39672 1:CAS:528:DC%2BD38XnvVeiurk%3D Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (2002) CIN85 participates in Cb-1-b down-regulation of receptor tyrosine kinases. J Biochem 277:39666–39672
18. 18. S Dasgupta MO Hoque S Upadhyay D Sidransky 2009 Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells Int J Cancer 125 2829 2835 19569044 10.1002/ijc.24701 1:CAS:528:DC%2BD1MXhtlSqsLnM Dasgupta S, Hoque MO, Upadhyay S, Sidransky D (2009) Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. Int J Cancer 125:2829–2835
19. 19. S Soubyran K Kowanetz I Szymkiewicz WY Langdon I Dikic 2002 CbI-CIN85-endophlin complex mediates ligand-induced downregulation of EGF receptors Nature 416 183 187 10.1038/416183a Soubyran S, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (2002) CbI-CIN85-endophlin complex mediates ligand-induced downregulation of EGF receptors. Nature 416:183–187
20. 20. SA Ettenberg MM Keane MM Nau M Frankel LM Wang JH Pierce S Lipkowitz 2009 cbl-b inhibits epidermal growth factor receptor signaling Oncogene 18 1855 1866 10.1038/sj.onc.1202499 Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S (2009) cbl-b inhibits epidermal growth factor receptor signaling. Oncogene 18:1855–1866
21. 21. G Levkowitz H Waterman SA Ettenberg M Katz AY Tsygankov I Alroy S Lavi K Iwai Y Reiss A Ciechanover 1999 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Mol Cell 4 1029 1040 10635327 10.1016/S1097-2765(00)80231-2 1:CAS:528:DC%2BD3cXislaqsw%3D%3D Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A et al (1999) Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 4:1029–1040
22. 22. O Kjaerulff L Brodin A Jung 2011 The structure and function of endophilin proteins Cell Biochem Biophys 60 137 154 21184288 10.1007/s12013-010-9137-5 1:CAS:528:DC%2BC3MXntlagtLY%3D Kjaerulff O, Brodin L, Jung A (2011) The structure and function of endophilin proteins. Cell Biochem Biophys 60:137–154
23. 23. Y Hoshida A Villanueva M Kobayashi J Peix DY Chiang A Camargo S Gupta J Moore MJ Wrobel J Lerner 2008 Gene expression in fixed tissues and outcome in hepatocellular carcinoma N Engl J Med 359 1995 2004 18923165 10.1056/NEJMoa0804525 1:CAS:528:DC%2BD1cXhtleisrzE Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, Camargo A, Gupta S, Moore J, Wrobel MJ, Lerner J et al (2008) Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 359:1995–2004
24. 24. S Sinha N Chunder N Mukherjee N Alam A Roy S Roychoudhury CK Panda 2008 Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early-and late-onset breast carcinoma Ann Surg Oncol 5 1070 1080 10.1245/s10434-007-9790-0 Sinha S, Chunder N, Mukherjee N, Alam N, Roy A, Roychoudhury S, Panda CK (2008) Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early-and late-onset breast carcinoma. Ann Surg Oncol 5:1070–1080
25. 25. A Ghosh S Ghosh GP Maiti MG Sabbir N Alam N Sikdar B Roy S Roychoudhury CK Panda 2009 SH3GL2 and CDKN2A/2B loci are independently altered in early dysplastic lesions of head and neck: correlation with HPV infection and tobacco habit J Pathol 217 408 419 19023882 10.1002/path.2464 1:CAS:528:DC%2BD1MXjtF2nur4%3D Ghosh A, Ghosh S, Maiti GP, Sabbir MG, Alam N, Sikdar N, Roy B, Roychoudhury S, Panda CK (2009) SH3GL2 and CDKN2A/2B loci are independently altered in early dysplastic lesions of head and neck: correlation with HPV infection and tobacco habit. J Pathol 217:408–419
26. 26. L Osterberg K Levan K Partheen U Delle B Olsson K Sundfeldt G Horvath 2009 Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas BMC Cancer 9 368 19835627 10.1186/1471-2407-9-368 Osterberg L, Levan K, Partheen K, Delle U, Olsson B, Sundfeldt K, Horvath G (2009) Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas. BMC Cancer 9:368
27. 27. T Hu C Li 2010 Convergence between Wnt-β-catenin and EGFR signaling in cancer Mol Cancer 9 236 20828404 10.1186/1476-4598-9-236 Hu T, Li C (2010) Convergence between Wnt-β-catenin and EGFR signaling in cancer. Mol Cancer 9:236
28. 28. D Vucic VM Dixit IE Wertz 2011 Ubiquitination in apoptosis: a post translational modification at the edge of life and death Nat Rev Mol Cell Biol 12 439 452 21697901 10.1038/nrm3143 1:CAS:528:DC%2BC3MXnvFSqu7o%3D Vucic D, Dixit VM, Wertz IE (2011) Ubiquitination in apoptosis: a post translational modification at the edge of life and death. Nat Rev Mol Cell Biol 12:439–452