IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments

Oncogene

Volumn 32, Issue 19, 2013, Pages 2412-2420

  Grkovic, S ^a   O'Reilly, V C ^a   Han, S ^a   Hong, M ^a   Baxter, R C ^a   Firth, S M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

autophagy; breast cancer; GRP78; IGFBP 3; starvation

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE TRANSFERASE; SMALL INTERFERING RNA; SOMATOMEDIN BINDING PROTEIN 3;

ARTICLE; AUTOPHAGY; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; IMMUNOPRECIPITATION; IN VIVO STUDY; MACROAUTOPHAGY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SOLID TUMOR; TUMOR MICROENVIRONMENT; UNFOLDED PROTEIN RESPONSE;

ANIMALS; AUTOPHAGY; BREAST NEOPLASMS; FEMALE; HEAT-SHOCK PROTEINS; HEK293 CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MCF-7 CELLS; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR MICROENVIRONMENT;

MUS;

EID: 84877588873     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.264     Document Type: Article

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