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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3389-3392

Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors

(6) Wang, Changning a Moseley, Christian K a Carlin, Stephen M a Wilson, Colin M a Neelamegam, Ramesh a Hooker, Jacob M a

a MASSACHUSETTS GENERAL HOSPITAL (United States)

Author keywords

Brain; Carbon 11; EMPA; Orexin; PET radiotracer

Indexed keywords

N ETHYL 2 (N (6 METHOXYPYRIDIN 3 YL) 2 METHYLPHENYLSULFONAMIDO) N (PYRIDIN 3 YLMETHYL)ACETAMIDE C 11; OREXIN 2 RECEPTOR; RADIOPHARMACEUTICAL AGENT; SODIUM IODIDE; TRACER; UNCLASSIFIED DRUG; AMINOPYRIDINE DERIVATIVE; CARBON; CARBONIC ACID DERIVATIVE; CESIUM; CESIUM CARBONATE; CHLOROTRIMETHYLSILANE; DIAGNOSTIC AGENT; N ETHYL 2 ((6 METHOXY PYRIDIN 3 YL) (TOLUENE 2 SULPHONYL)AMINO) N PYRIDIN 3 YLMETHYL ACETAMIDE; N-ETHYL-2-((6-METHOXY-PYRIDIN-3-YL)-(TOLUENE-2-SULPHONYL)AMINO)-N-PYRIDIN-3-YLMETHYL-ACETAMIDE; OREXIN RECEPTOR; SULFONAMIDE; TRIMETHYLSILYL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; IC 50; IN VITRO STUDY; LIPOPHILICITY; MALE; MOLECULAR WEIGHT; NONHUMAN; PLASMA PROTEIN BINDING; PROTEIN METHYLATION; RAT; ANIMAL; BABOON; BRAIN; CHEMISTRY; DRUG ANTAGONISM; HALF LIFE TIME; HUMAN; METABOLISM; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; SYNTHESIS; TISSUE DISTRIBUTION; ANTAGONISTS AND INHIBITORS; DIAGNOSTIC USE;

PAPIO; PRIMATES; RATTUS; RODENTIA;

AMINOPYRIDINES; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CARBONATES; CESIUM; HALF-LIFE; HUMANS; OREXIN RECEPTORS; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; SODIUM IODIDE; SULFONAMIDES; TISSUE DISTRIBUTION; TRIMETHYLSILYL COMPOUNDS;

EID: 84877583773 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.079 Document Type: Article

Times cited : (22)

References (29)

1
- 1842537953
- J.M. Siegel Annu. Rev. Psychol. 55 2004 125
- (2004) Annu. Rev. Psychol. , vol.55 , pp. 125
- Siegel, J.M.¹

2
- 84859794857
- C. Dall'aglio, F. Mercati, M. Maranesi, and C. Boiti Peptides 35 2012 36
- (2012) Peptides , vol.35 , pp. 36
- Dall'Aglio, C.¹ Mercati, F.² Maranesi, M.³ Boiti, C.⁴

3
- 34447305442
- I. Rainero, E. Rubino, W. Valfre, S. Gallone, P. De Martino, E. Zampella, and L. Pinessi J. Headache Pain 8 2007 152
- (2007) J. Headache Pain , vol.8 , pp. 152
- Rainero, I.¹ Rubino, E.² Valfre, W.³ Gallone, S.⁴ De Martino, P.⁵ Zampella, E.⁶ Pinessi, L.⁷

4
- 46749129773
- I. Rainero, S. Gallone, E. Rubino, P. Ponzo, W. Valfre, E. Binello, P. Fenoglio, S. Gentile, M. Anoaica, M. Gasparini, and L. Pinessi Headache 48 2008 1108
- (2008) Headache , vol.48 , pp. 1108
- Rainero, I.¹ Gallone, S.² Rubino, E.³ Ponzo, P.⁴ Valfre, W.⁵ Binello, E.⁶ Fenoglio, P.⁷ Gentile, S.⁸ Anoaica, M.⁹ Gasparini, M.¹⁰ Pinessi, L.¹¹

5
- 33846956089
- T.E. Scammell, and C.B. Saper Nat. Med. 13 2007 126
- (2007) Nat. Med. , vol.13 , pp. 126
- Scammell, T.E.¹ Saper, C.B.²

6
- 84856359731
- J.P. Nixon, C.M. Kotz, C.M. Novak, C.J. Billington, and J.A. Teske Handb. Exp. Pharmacol. 209 2012 77
- (2012) Handb. Exp. Pharmacol. , vol.209 , pp. 77
- Nixon, J.P.¹ Kotz, C.M.² Novak, C.M.³ Billington, C.J.⁴ Teske, J.A.⁵

7
- 78149241646
- Y. Li, H. Wang, K. Qi, X. Chen, S. Li, N. Sui, and G.J. Kirouac Physiol. Behav. 102 2011 42
- (2011) Physiol. Behav. , vol.102 , pp. 42
- Li, Y.¹ Wang, H.² Qi, K.³ Chen, X.⁴ Li, S.⁵ Sui, N.⁶ Kirouac, G.J.⁷

8
- 35148898783
- P. Silveyra, V. Lux-Lantos, and C. Libertun Am. J. Physiol. Endocrinol. Metab. 293 2007 E977
- (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. 977
- Silveyra, P.¹ Lux-Lantos, V.² Libertun, C.³

9
- 0037377565
- C.V. de Oliveira, M.P. Rosas-Arellano, L.P. Solano-Flores, and J. Ciriello Am. J. Physiol. Heart Circ. Physiol. 284 2003
- (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.284
- De Oliveira, C.V.¹ Rosas-Arellano, M.P.² Solano-Flores, L.P.³ Ciriello, J.⁴

10
- 0037470830
- J. Ciriello, M.P. Rosas-Arellano, L.P. Solano-Flores, and C.V. de Oliveira Brain Res. 967 2003 123
- (2003) Brain Res. , vol.967 , pp. 123
- Ciriello, J.¹ Rosas-Arellano, M.P.² Solano-Flores, L.P.³ De Oliveira, C.V.⁴

11
- 84866330675
- L. Assisi, S. Tafuri, G. Liguori, S. Paino, L.M. Pavone, N. Staiano, and A. Vittoria Cell Tissue Res. 2012
- (2012) Cell Tissue Res.
- Assisi, L.¹ Tafuri, S.² Liguori, G.³ Paino, S.⁴ Pavone, L.M.⁵ Staiano, N.⁶ Vittoria, A.⁷

12
- 17844395960
- M. Ehrstrom, T. Gustafsson, A. Finn, A. Kirchgessner, P. Gryback, H. Jacobsson, P.M. Hellstrom, and E. Naslund J. Clin. Endocrinol. Metab. 90 2005 2370
- (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2370
- Ehrstrom, M.¹ Gustafsson, T.² Finn, A.³ Kirchgessner, A.⁴ Gryback, P.⁵ Jacobsson, H.⁶ Hellstrom, P.M.⁷ Naslund, E.⁸

13
- 0034748701
- G. Mazzocchi, L.K. Malendowicz, F. Aragona, P. Rebuffat, L. Gottardo, and G.G. Nussdorfer J. Clin. Endocrinol. Metab. 86 2001 4818
- (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4818
- Mazzocchi, G.¹ Malendowicz, L.K.² Aragona, F.³ Rebuffat, P.⁴ Gottardo, L.⁵ Nussdorfer, G.G.⁶

14
- 21244465999
- R. Spinazzi, M. Rucinski, G. Neri, L.K. Malendowicz, and G.G. Nussdorfer J. Clin. Endocrinol. Metab. 90 2005 3544
- (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 3544
- Spinazzi, R.¹ Rucinski, M.² Neri, G.³ Malendowicz, L.K.⁴ Nussdorfer, G.G.⁵

15
- 35648944178
- K. Zwirska-Korczala, M. Adamczyk-Sowa, P. Sowa, K. Pilc, R. Suchanek, K. Pierzchala, G. Namyslowski, M. Misiolek, K. Sodowski, I. Kato, A. Kuwahara, and R. Zabielski J. Physiol. Pharmacol. 58 2007 53
- (2007) J. Physiol. Pharmacol. , vol.58 , pp. 53
- Zwirska-Korczala, K.¹ Adamczyk-Sowa, M.² Sowa, P.³ Pilc, K.⁴ Suchanek, R.⁵ Pierzchala, K.⁶ Namyslowski, G.⁷ Misiolek, M.⁸ Sodowski, K.⁹ Kato, I.¹⁰ Kuwahara, A.¹¹ Zabielski, R.¹²

16
- 10744230937
- M. Nakabayashi, T. Suzuki, K. Takahashi, K. Totsune, Y. Muramatsu, C. Kaneko, F. Date, J. Takeyama, A.D. Darnel, T. Moriya, and H. Sasano Mol. Cell. Endocrinol. 205 2003 43
- (2003) Mol. Cell. Endocrinol. , vol.205 , pp. 43
- Nakabayashi, M.¹ Suzuki, T.² Takahashi, K.³ Totsune, K.⁴ Muramatsu, Y.⁵ Kaneko, C.⁶ Date, F.⁷ Takeyama, J.⁸ Darnel, A.D.⁹ Moriya, T.¹⁰ Sasano, H.¹¹

17
- 33645391991
- K. Takahashi, Z. Arihara, T. Suzuki, M. Sone, K. Kikuchi, H. Sasano, O. Murakami, and K. Totsune Peptides 27 2006 871
- (2006) Peptides , vol.27 , pp. 871
- Takahashi, K.¹ Arihara, Z.² Suzuki, T.³ Sone, M.⁴ Kikuchi, K.⁵ Sasano, H.⁶ Murakami, O.⁷ Totsune, K.⁸

18
- 27744562642
- M. Ehrstrom, F. Levin, A.L. Kirchgessner, P.T. Schmidt, L.M. Hilsted, P. Gryback, H. Jacobsson, P.M. Hellstrom, and E. Naslund Regul. Pept. 132 2005 9
- (2005) Regul. Pept. , vol.132 , pp. 9
- Ehrstrom, M.¹ Levin, F.² Kirchgessner, A.L.³ Schmidt, P.T.⁴ Hilsted, L.M.⁵ Gryback, P.⁶ Jacobsson, H.⁷ Hellstrom, P.M.⁸ Naslund, E.⁹

19
- 33846979755
- C. Brisbare-Roch, J. Dingemanse, R. Koberstein, P. Hoever, H. Aissaoui, S. Flores, C. Mueller, O. Nayler, J. van Gerven, S.L. de Haas, P. Hess, C. Qiu, S. Buchmann, M. Scherz, T. Weller, W. Fischli, M. Clozel, and F. Jenck Nat. Med. 13 2007 150
- (2007) Nat. Med. , vol.13 , pp. 150
- Brisbare-Roch, C.¹ Dingemanse, J.² Koberstein, R.³ Hoever, P.⁴ Aissaoui, H.⁵ Flores, S.⁶ Mueller, C.⁷ Nayler, O.⁸ Van Gerven, J.⁹ De Haas, S.L.¹⁰ Hess, P.¹¹ Qiu, C.¹² Buchmann, S.¹³ Scherz, M.¹⁴ Weller, T.¹⁵ Fischli, W.¹⁶ Clozel, M.¹⁷ Jenck, F.¹⁸

20
- 67749103988
- D.B. Whitman, C.D. Cox, M.J. Breslin, K.M. Brashear, J.D. Schreier, M.J. Bogusky, R.A. Bednar, W. Lemaire, J.G. Bruno, G.D. Hartman, D.R. Reiss, C.M. Harrell, R.L. Kraus, Y. Li, S.L. Garson, S.M. Doran, T. Prueksaritanont, C. Li, C.J. Winrow, K.S. Koblan, J.J. Renger, and P.J. Coleman ChemMedChem 4 2009 1069
- (2009) ChemMedChem , vol.4 , pp. 1069
- Whitman, D.B.¹ Cox, C.D.² Breslin, M.J.³ Brashear, K.M.⁴ Schreier, J.D.⁵ Bogusky, M.J.⁶ Bednar, R.A.⁷ Lemaire, W.⁸ Bruno, J.G.⁹ Hartman, G.D.¹⁰ Reiss, D.R.¹¹ Harrell, C.M.¹² Kraus, R.L.¹³ Li, Y.¹⁴ Garson, S.L.¹⁵ Doran, S.M.¹⁶ Prueksaritanont, T.¹⁷ Li, C.¹⁸ Winrow, C.J.¹⁹ Koblan, K.S.²⁰ Renger, J.J.²¹ Coleman, P.J.²² more..

21
- 65549153262
- C.D. Cox, G.B. McGaughey, M.J. Bogusky, D.B. Whitman, R.G. Ball, C.J. Winrow, J.J. Renger, and P.J. Coleman Bioorg. Med. Chem. Lett. 19 2009 2997
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2997
- Cox, C.D.¹ McGaughey, G.B.² Bogusky, M.J.³ Whitman, D.B.⁴ Ball, R.G.⁵ Winrow, C.J.⁶ Renger, J.J.⁷ Coleman, P.J.⁸

22
- 69549083464
- P. Malherbe, E. Borroni, E. Pinard, J.G. Wettstein, and F. Knoflach Mol. Pharmacol. 76 2009 618
- (2009) Mol. Pharmacol. , vol.76 , pp. 618
- Malherbe, P.¹ Borroni, E.² Pinard, E.³ Wettstein, J.G.⁴ Knoflach, F.⁵

23
- 0008390266
- L. de Lecea, T.S. Kilduff, C. Peyron, X. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L. Battenberg, V.T. Gautvik, F.S. Bartlett II, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik, and J.G. Sutcliffe Proc. Natl. Acad. Sci. U.S.A. 95 1998 322
- (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 322
- De Lecea, L.¹ Kilduff, T.S.² Peyron, C.³ Gao, X.⁴ Foye, P.E.⁵ Danielson, P.E.⁶ Fukuhara, C.⁷ Battenberg, E.L.⁸ Gautvik, V.T.⁹ Bartlett, I.I.F.S.¹⁰ Frankel, W.N.¹¹ Van Den Pol, A.N.¹² Bloom, F.E.¹³ Gautvik, K.M.¹⁴ Sutcliffe, J.G.¹⁵

24
- 40949095655
- S.P. Alexander, A. Mathie, and J.A. Peters Br. J. Pharmacol. 153 2008 S1
- (2008) Br. J. Pharmacol. , vol.153 , pp. 1
- Alexander, S.P.¹ Mathie, A.² Peters, J.A.³

25
- 0032489093
- T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richarson, G.P. Kozlowski, S. Wilson, J.R. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, and M. Yanagisawa Cell 92 1998 1
- (1998) Cell , vol.92 , pp. 1
- Sakurai, T.¹ Amemiya, A.² Ishii, M.³ Matsuzaki, I.⁴ Chemelli, R.M.⁵ Tanaka, H.⁶ Williams, S.C.⁷ Richarson, J.A.⁸ Kozlowski, G.P.⁹ Wilson, S.¹⁰ Arch, J.R.¹¹ Buckingham, R.E.¹² Haynes, A.C.¹³ Carr, S.A.¹⁴ Annan, R.S.¹⁵ McNulty, D.E.¹⁶ Liu, W.S.¹⁷ Terrett, J.A.¹⁸ Elshourbagy, N.A.¹⁹ Bergsma, D.J.²⁰ Yanagisawa, M.²¹ more..

26
- 53349168908
- A.G. Cole, I.L. Stroke, L.Y. Qin, Z. Hussain, S. Simhadri, M.R. Brescia, F.S. Waksmunski, B. Strohl, J.E. Tellew, J.P. Williams, J. Saunders, K.C. Appell, I. Henderson, and M.L. Webb Bioorg. Med. Chem. Lett. 18 2008 5420
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5420
- Cole, A.G.¹ Stroke, I.L.² Qin, L.Y.³ Hussain, Z.⁴ Simhadri, S.⁵ Brescia, M.R.⁶ Waksmunski, F.S.⁷ Strohl, B.⁸ Tellew, J.E.⁹ Williams, J.P.¹⁰ Saunders, J.¹¹ Appell, K.C.¹² Henderson, I.¹³ Webb, M.L.¹⁴

27
- 79955569841
- D.A. Perrey, B.P. Gilmour, S.P. Runyon, B.F. Thomas, and Y. Zhang Bioorg. Med. Chem. Lett. 21 2011 2980
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 2980
- Perrey, D.A.¹ Gilmour, B.P.² Runyon, S.P.³ Thomas, B.F.⁴ Zhang, Y.⁵

28
- 1342322672
- C.J. Langmead, J.C. Jerman, S.J. Brough, C. Scott, R.A. Porter, and H.J. Herdon Br. J. Pharmacol. 141 2004 340
- (2004) Br. J. Pharmacol. , vol.141 , pp. 340
- Langmead, C.J.¹ Jerman, J.C.² Brough, S.J.³ Scott, C.⁴ Porter, R.A.⁵ Herdon, H.J.⁶

29
- 67649890888
- P. Malherbe, E. Borroni, L. Gobbi, H. Knust, M. Nettekoven, E. Pinard, O. Roche, M. Rogers-Evans, J.G. Wettstein, and J.L. Moreau Br. J. Pharmacol. 156 2009 1326
- (2009) Br. J. Pharmacol. , vol.156 , pp. 1326
- Malherbe, P.¹ Borroni, E.² Gobbi, L.³ Knust, H.⁴ Nettekoven, M.⁵ Pinard, E.⁶ Roche, O.⁷ Rogers-Evans, M.⁸ Wettstein, J.G.⁹ Moreau, J.L.¹⁰

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