A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3137-3139

  Guo, Huanjie ^a,b   Zhao, Huanxin ^a   Kanno, Yuichiro ^c   Li, Wei ^c   Mu, Yanling ^a   Kuang, Xinzhu ^c   Inouye, Yoshio ^c   Koike, Kazuo ^c   Jiang, Haipeng ^d   Bai, Hong ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF JINAN   (China)

^c TOHO UNIVERSITY   (Japan)

^d WUHAN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

AMPK activation; Dihydrochalcone; Homoisoflavonoids; Polygonatum odoratum

Indexed keywords

5,7 DIHYDROXYL 6 METHYL 3 (4' HYDROXYLBENZYL) CHROMAN 4 ONE; 5,7 DIHYDROXYL 6 METHYL 8 METHOXYL 3 (4' HYDROXYLBENZYL) CHROMAN 4 ONE; 5,7 DIHYDROXYL 6,8 DIMETHYL 3 (4' HYDROXYLBENZYL) CHROMAN 4 ONE; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ANTIDIABETIC AGENT; CHALCONE DERIVATIVE; DIHYDROCHALCONE; ENZYME ACTIVATOR; HOMOISOFLAVONOID DERIVATIVE; ISOFLAVONOID; PLANT EXTRACT; POLYGONATONE A; POLYGONATONE B; POLYGONATONE C; POLYGONATONE D; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; POLYGONATUM; POLYGONATUM ODORATUM; RAT; SPECTROSCOPY; STRUCTURE ANALYSIS;

3T3-L1 CELLS; ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; CHALCONES; ISOFLAVONES; MICE; PHOSPHORYLATION; POLYGONATUM; RATS; RHIZOME;

POLYGONATUM ODORATUM; RATTUS;

EID: 84877578749     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.027     Document Type: Article

References (17)

1. B.B. Zhang, G.C. Zhou, and C. Li Cell Metab. 9 2009 407
2. S.P. Davies, D. Carling, M.R. Munday, and D.G. Hardie Eur. J. Biochem. 203 1992 615
3. P.R. Clarke, and D.G. Hardie EMBO J. 9 1990 2439
4. E.J. Kurth-Kraczek, M.F. Hirshman, L.J. Goodyear, and W.W. Winder Diabetes 48 1999 1667
5. D.G. Hardie, F.A. Ross, and S.A. Hawley Chem. Biol. 19 2012 1222
6. R.A.K. Srivastava, S.L. Pinkosky, S. Filippov, J.C. Hanselman, C.T. Cramer, and R.S. Newton J. Lipid Res. 53 2012 2490
7. Anonymous. A Dictionary of the Traditional Chinese Medicine; China Medical Science and Technology Press: Beijing, 1993; Vol. 1, pp 1331.
8. Y. Deng, K. He, X. Ye, X. Chen, J. Huang, X. Li, L. Yuan, Y. Jin, Q. Jin, and P. Li J. Ethnopharmacol. 141 2012 228
9. X. Shu, J. Lv, J. Tao, G. Li, H. Li, and N. Ma J. Ethnopharmacol. 124 2009 539
10. S.B. Choi, and S. Park Biosci. Biotechnol. Biochem. 66 2002 2036
11. D.M. Wang, D.W. Li, W. Zhu, and P. Peng Nat. Prod. Res. 23 2009 580
12. A. Nguyen, J. Fontaine, H. Malonne, and P. Duez Phytochemistry 67 2006 2159
13. M. Adinolfi, G. Barone, M.M. Corsaro, L. Mangoni, R. Lanzetta, and M. Parrilli Tetrahedron 44 1988 4981
14. T.D. Cuong, T.M. Hung, J.C. Kim, E.H. Kim, H.M. Woo, S.J. Choi, J.H. Lee, and B.S. Min J. Nat. Prod. 75 2012 2069
15. H. Takikawa, and K. Suzuki Org. Lett. 9 2007 2713
16. M. Cuendet, O. Potterat, A. Salvi, B. Testa, and K. Hostettmann Phytochemistry 54 2000 871
17. H. Zhang, F. Yang, J. Qi, X.C. Song, Z.F. Hu, D.N. Zhu, and B.Y. Yu J. Nat. Prod. 73 2010 548