Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 8, 2013, Pages 1129-1135

  Convertini, Paolo ^a   Zhang, Jiayu ^a   de la Grange, Pierre ^b   Hayward, Lawrence J ^c   Zhu, Haining ^a   Stamm, Stefan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b SAINT LOUIS HOSPITAL   (France)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

ALS; Amyotrophic lateral sclerosis; Array analysis; FUS; Fused in sarcoma

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II INHIBITOR 2; FUSED IN SARCOMA PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENOME ANALYSIS; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION;

AMYOTROPHIC LATERAL SCLEROSIS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE; CELL NUCLEUS; CHROMATIN; CYTOPLASM; EXONS; GENOME-WIDE ASSOCIATION STUDY; HEK293 CELLS; HUMANS; MUTATION; PROMOTER REGIONS, GENETIC; RNA PRECURSORS; RNA SPLICING; RNA-BINDING PROTEIN FUS;

EID: 84877342846     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.03.015     Document Type: Article

References (25)

1. Vance C., Rogelj B., Hortobagyi T., De Vos K.J., Nishimura A.L., Sreedharan J., Hu X., Smith B., Ruddy D., Wright P., Ganesalingam J., Williams K.L., Tripathi V., Al-Saraj S., Al-Chalabi A., Leigh P.N., Blair I.P., Nicholson G., de Belleroche J., Gallo J.M., Miller C.C., Shaw C.E. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 2009, 323:1208-1211.
2. Kwiatkowski T.J., Bosco D.A., Leclerc A.L., Tamrazian E., Vanderburg C.R., Russ C., Davis A., Gilchrist J., Kasarskis E.J., Munsat T., Valdmanis P., Rouleau G.A., Hosler B.A., Cortelli P., de Jong P.J., Yoshinaga Y., Haines J.L., Pericak-Vance M.A., Yan J., Ticozzi N., Siddique T., McKenna-Yasek D., Sapp P.C., Horvitz H.R., Landers J.E., Brown R.H. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 2009, 323:1205-1208.
3. Bertolotti A., Lutz Y., Heard D.J., Chambon P., Tora L. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. EMBO J. 1996, 15:5022-5031.
4. Bertolotti A., Melot T., Acker J., Vigneron M., Delattre O., Tora L. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol. Cell. Biol. 1998, 18:1489-1497.
5. Zhou Z., Licklider L.J., Gygi S.P., Reed R. Comprehensive proteomic analysis of the human spliceosome. Nature 2002, 419:182-185.
6. Tan A.Y., Manley J.L. TLS inhibits RNA polymerase III transcription. Mol. Cell. Biol. 2010, 30:186-196.
7. Kanai Y., Dohmae N., Hirokawa N. Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 2004, 43:513-525.
8. Lui X., Niu C., Ren J., Zhang J., Xie X.X., Zhu H., Feng W., Gong W. The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Biochem. Biophys. Acta 2013, 1832:375-385.
9. Olofsson A., Willen H., Goransson M., Engstrom K., Meis-Kindblom J.M., Stenman G., Kindblom L.G., Aman P. Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas. Int. J. Oncol. 2004, 25:1349-1355.
10. Tan A.Y., Manley J.L. TLS/FUS: a protein in cancer and ALS. Cell Cycle 2012, 11:3349-3350.
11. Lagier-Tourenne C., Polymenidou M., Cleveland D.W. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum. Mol. Genet. 2010, 19:R46-R64.
12. Dormann D., Rodde R., Edbauer D., Bentmann E., Fischer I., Hruscha A., Than M.E., Mackenzie I.R., Capell A., Schmid B., Neumann M., Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J. 2010, 29:2841-2857.
13. Gal J., Zhang J., Kwinter D.M., Zhai J., Jia H., Jia J., Zhu H. Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol. Aging 2011, 32:2323.e27-2323.e40.
14. Bosco D.A., Lemay N., Ko H.K., Zhou H., Burke C., Kwiatkowski T.J., Sapp P., McKenna-Yasek D., Brown R.H., Hayward L.J. Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Hum. Mol. Genet. 2010, 19:4160-4175.
15. Xia R., Liu Y., Yang L., Gal J., Zhu H., Jia J. Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol. Neurodegener. 2012, 7:10.
16. Wang J.W., Brent J.R., Tomlinson A., Shneider N.A., McCabe B.D. The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J. Clin. Invest. 2011, 121:4118-4126.
17. Chen Y., Yang M., Deng J., Chen X., Ye Y., Zhu L., Liu J., Ye H., Shen Y., Li Y., Rao E.J., Fushimi K., Zhou X., Bigio E.H., Mesulam M., Xu Q., Wu J.Y. Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. Protein Cell 2011, 2:477-486.
18. Rogelj B., Easton L.E., Bogu G.K., Stanton L.W., Rot G., Curk T., Zupan B., Sugimoto Y., Modic M., Haberman N., Tollervey J., Fujii R., Takumi T., Shaw C.E., Ule J. Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. Sci. Rep. 2012, 2:603.
19. Lagier-Tourenne C., Polymenidou M., Hutt K.R., Vu A.Q., Baughn M., Huelga S.C., Clutario K.M., Ling S.C., Liang T.Y., Mazur C., Wancewicz E., Kim A.S., Watt A., Freier S., Hicks G.G., Donohue J.P., Shiue L., Bennett C.F., Ravits J., Cleveland D.W., Yeo G.W. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat. Neurosci. 2012, 15:1488-1497.
20. Hoell J.I., Larsson E., Runge S., Nusbaum J.D., Duggimpudi S., Farazi T.A., Hafner M., Borkhardt A., Sander C., Tuschl T. RNA targets of wild-type and mutant FET family proteins. Nat. Struct. Mol. Biol. 2011, 18:1428-1431.
21. Kapur K., Jiang H., Xing Y., Wong W.H. Cross-hybridization modeling on Affymetrix exon arrays. Bioinformatics 2008, 24:2887-2893.
22. Shen S., Warzecha C.C., Carstens R.P., Xing Y. MADS+: discovery of differential splicing events from Affymetrix exon junction array data. Bioinformatics 2010, 26:268-269.
23. Okabe T., Nakamura T., Nishimura Y.N., Kohu K., Ohwada S., Morishita Y., Akiyama T. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-d-aspartate receptor signaling. J. Biol. Chem. 2003, 278:9920-9927.
24. Tateno M., Sadakata H., Tanaka M., Itohara S., Shin R.M., Miura M., Masuda M., Aosaki T., Urushitani M., Misawa H., Takahashi R. Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum. Mol. Genet. 2004, 13:2183-2196.
25. Leonard A.S., Lim I.A., Hemsworth D.E., Horne M.C., Hell J.W. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-d-aspartate receptor. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3239-3244.