Bevacizumab for the treatment of recurrent ovarian cancer: A retrospective cohort study

European Journal of Gynaecological Oncology

Volumn 34, Issue 2, 2013, Pages 113-119

  Akers, S N ^a   Riebandt, G ^a   Miller, A ^a   Groman, A ^a   Odunsi, K ^a   Lele, S ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Bevacizumab; Chemotherapy; Endometrial carcinoma; Ichthyosis uteri; Ovarian cancer; Squamous cell carcinoma

Indexed keywords

BEVACIZUMAB; CA 125 ANTIGEN; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; NAVELBINE; PACLITAXEL; PEMETREXED; TOPOTECAN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; COHORT ANALYSIS; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG FATALITY; DRUG WITHDRAWAL; ENTEROCUTANEOUS FISTULA; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HISTOLOGY; HUMAN; HYPERTENSION; INTESTINE OBSTRUCTION; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; OVARY CANCER; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; RECURRENT CANCER; RETROSPECTIVE STUDY; TREATMENT OUTCOME; TREATMENT RESPONSE; VENOUS THROMBOEMBOLISM;

ADULT; AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; COHORT STUDIES; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84877328722     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Jemal A., Siegel R., Xu J., Ward E.: "Cancer statistics, 2010". CA Cancer J. Clin., 2010, 60, p. 277.
2. Young R.C. Decker D.G., Wharton J.T., Piver M.S., Sindelar W.F. Edwards B.K. et al.: "Staging laparotomy in early ovarian cancer". JAMA, 1983, 250, 3072.
3. Hurt J.D., Richardson D.L., Seamon L.G., Fowler J.F., Copeland L.J., Cohn D.E. et al.: "Sustained progression-free survival with weekly paclitaxel and bevacizumab in recurrent ovarian cancer". Gynecol. Oncol., 2009, 115, 396.
4. Markman M.: "Antineoplastic agents in the management of ovarian cancer: current status and emerging therapeutic strategies". Trends Pharmacol. Sci., 2008, 29, 515.
5. Stone R.L., Sood A.K., Coleman R.L.: "Collateral damage: toxic effects of targeted antiangiogenic therapies in ovarian cancer". Lancet Oncol., 2010, 11, 465.
6. Santin A.D., Hermonat P.L., Ravaggi A., Cannon M.J., Pecorelli S., Parham G.P.: "Secretion of vascular endothelial growth factor in ovarian cancer". Eur. J. Gynaecol. Oncol., 1999, 20, 177.
7. Penson R.T., Dizon D.S., Cannistra S.A., Roche M.R., Krasner C.N., Berlin S.T. et al.: "Phase II study of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab as first-line chemotherapy for advanced mullerian tumors". J. Clin. Oncol., 2010, 28, 154.
8. Alvarez A.A., Krigman H.R., Whitaker R.S., Dodge R.K., Rodriguez G.C.: "The prognostic significance of angiogenesis in epithelial ovarian carcinoma". Clin. Cancer Res., 1999, 5, 587.
9. Gasparini G., Weidner N., Bevilacqua P., Maluta S., Dalla Palma P., Caffo O. et al.: "Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma". J. Clin. Oncol., 1994, 12, 454.
10. Hollingsworth H.C., Kohn E.C., Steinberg S.M., Rothenberg M.L., Merino M.J.: "Tumor angiogenesis in advanced stage ovarian carcinoma". Am. J. Pathol., 1995, 147, 33.
11. Nakanishi Y., Kodama J., Yoshinouchi M., Tokumo K., Kamimura S., Okuda H. et al.: "The expression of vascular endothelial growth factor and transforming growth factor-beta associates with angiogenesis in epithelial ovarian cancer". Int. J. Gynecol. Pathol., 1997, 16, 256.
12. Paley P.J., Staskus K.A., Gebhard K., Mohanraj D., Twiggs L.B., Carson L.F. et al.: "Vascular endothelial growth factor expression in early stage ovarian carcinoma". Cancer, 1997, 80, 98.
13. Cooper B.C., Ritchie J.M., Broghammer C.L., Coffin J., Sorosky J.K., Buller R.E. et al.: "Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer". Clin. Cancer Res., 2002, 8, 3193.
14. Dvorak H.F.: "Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy". J. Clin. Oncol., 2002, 20, 4368.
15. Ferrara N.: "Molecular and biological properties of vascular endothelial growth factor". J. Mol. Med., 1999, 77, 527
16. Yoneda J., Kuniyasu H., Crispens M.A., Price J.E., Bucana C.D., Fidler I.J.: "Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice". J. Natl. Cancer Inst., 1998, 90, 447.
17. Richardson D.L., Backes F.J., Seamon L.G., Zanagnolo V., O'Malley D.M., Cohn D.E. et al.: "Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer". Gynecol. Oncol., 2008, 111, 461.
18. Cannistra S.A., Matulonis U.A., Penson R.T., Hambleton J., Dupont J., Mackey H. et al.: "Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer". J. Clin. Oncol., 2007, 25, 5180.
19. Cohn D.E., Valmadre S., Resnick K.E., Eaton L.A., Copeland L.J., Fowler J.M.: "Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer". Gynecol. Oncol., 2006, 102, 134.
20. Sfakianos G.P., Numnum T.M., Halverson C.B., Panjeti D., Kendrick J.Et., Straughn J.M. Jr.: "The risk of gastrointestinal perforation and/or fistula in patients with recurrent ovarian cancer receiving bevacizumab compared to standard chemotherapy: a retrospective cohort study". Gynecol. Oncol., 2009, 114, 424.
21. Cohen M.H. Gootenberg J., Keegan P., Pazdur R.: "FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer". Oncologist, 2007, 12, 713.
22. Kabbinavar F., Hurwitz H.I., Fehrenbacher L., Meropol N.J., Novotny W.F., Lieberman G. et al.: "Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer". J. Clin. Oncol., 2003, 21, 60.
23. Miller K., Wang M., Gralow J., Dickler M., Cobleigh M., Perez E.A. et al.: "Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer". N. Engl. J. Med., 2007, 357, 2666.
24. Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A. et al.: "Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer". N. Engl. J. Med., 2006, 355, 2542.
25. Yang J.C. Haworth L., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L. et al.: "A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer". N. Engl. J. Med., 2003, 349, 427.
26. Burger R.A. Sill M.W., Monk B.J., Greer B.E., Sorosky J.I.: Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study". J. Clin. Oncol., 2007, 25, 5165.
27. Garcia, A.A., Hirte H., Fleming G., Yang D., Tsao-Wei D.D., Roman L. et al.: "Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia". J. Clin. Oncol., 2008, 26, 76.
28. Wright J.D. Secord A.A., Numnum T.M., Rocconi R.P., Powell M.A., Berchuck A. et al.: "A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer". Int. J. Gynecol. Cancer, 2008, 18, 400.
29. Burger R., Brady M., Bookman M., Walker J., Homesley H., Fowler J. et al.: "Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study". J. Clin. Oncol., 2010, 28, 18s.
30. Pfisterer J., Perren T., Smart A.M., Ledermann J., Selle F., Kristensen G., et al.: "On behalf of ICON7 GCIG collaborators. A randomised controlled trial of bevacizumab in women with newly diagnosed epithelial ovarian, primary peritoneal or fallopian tube cancer". Int. J. Gynecol. Oncol., 2010, 20, 2.
31. Perren T., Swart A.M., Pfisterer J., Ledermann J., Lortholary A., Kristensen G. et al.: "On behalf of GCIG ICON7 collaborators. A phase III randomized gynecologic cancer intergroup trial of concurrent bevacizumab and chemotherapy followed by maintenance bevacizumab, versus chemotherapy alone in women with newly diagnosed epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC)". ESMO, 2010, Abstract LBA4.
32. Burger R.A., Brady M.F., Bookman M.A. et al.: "Phase II trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC) or fallopian tube cancer (FTC): A Gynecologic Oncology Group study". J. Clin. Oncol., 2010, 28, 5s.
33. Aghajanian C., Finkler N., Rutherford T., Smith D., Yi J., Parmar H. et al.: "OCEANS: A randomized, double-blinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC)". J. Clin. Oncol., 2011, 29, LBA5007.
34. Randall L.M., Monk B.J.: "Bevacizumab toxicities and their management in ovarian cancer". Gynecol. Oncol., 2010, 117, 497.
35. Therasse P., Arbuck S.G., Eisenhauer E.A., Wanders J., Kaplan R.S., Rubinstein L. et al.: "New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada". J. Natl. Cancer Inst., 2000, 92, 205.
36. Guppy A.E., Rustin G.J.: "CA125 response: can it replace the traditional response criteria in ovarian cancer". Oncologist, 2002, 7, 437.
37. Nimeiri H.S., Oza A.M., Morgan R.J., Friberg G., Kasza K., Faoro L. et al.: "Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia". Gynecol. Oncol., 2008, 110, 49.
38. McGonigle K.F., Muntz H.G., Vuky J.L., Paley P.J., VD S., Gray H.J. et al.: "Phase II prospective study of weekly topotecan and bevacizumab in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer". Gynecol. Oncol., 2009, 112, 145.
39. Loizzi V., Cormio G., Resta L., Rossi C.A., Di Gilio A.R., Cuccovillo A. et al.: "Neoadjuvant chemotherapy in advanced ovarian cancer: a case-control study". Int. J. Gynecol. Cancer, 2005, 15, 217.
40. Allegra C.J., Yothers G., O'Connell M.J., Sharif S., Colangelo L.H., Lopa S.H. et al.: "Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer". J. Clin. Oncol., 2009, 27, 3385.
41. Escudier B., Pluzanska A., Koralewski P., Ravaud A., Bracarda S., Szczylik C. et al.: "Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial". Lancet, 2007, 370, 2103.
42. Giantonio B.J., Catalano P.J., Meropol N.J., O'Dwyer P.J., Mitchell E.P., Alberts S.R. et al.: "Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200". J. Clin. Oncol., 2007, 25, 1539.
43. Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W. et al.: "Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer". N. Engl. J. Med., 2004, 350, 2335.
44. Miller K.D., Chap L.I., Holmes F.A., Cobleigh M.A., Marcom P.K., Fehrenbacher L. et al.: "Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer". J. Clin. Oncol., 2005, 23, 792.
45. Reck M., von Pavel J., Zatloukal P., Ramlau R., Gorbounova V., Hirsh V. et al.: "Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil". J. Clin. Oncol., 2009, 27, 1227.
46. Saltz L.B. Clarke S., Diaz-Rubio E., Scheithauer W., Figer A., Wong R. et al.: "Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study". J. Clin. Oncol., 2008, 26, 2013.
47. Burger R.A., Brady M.F., Bookman M.A., Fleming G.F., Monk B.J., Huang H. et al.: "Incorporation of bevacizumab in the primary treatment of ovarian cancer". N. Engl. J. Med., 2011, 365, 2473.