메뉴 건너뛰기




Volumn 11, Issue 5, 2010, Pages 465-475

Collateral damage: Toxic effects of targeted antiangiogenic therapies in ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; AFLIBERCEPT; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; BIBF 1120; CARBOPLATIN; CEDIRANIB; CLOBETASOL; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; FOSBRETABULIN; GEMCITABINE; IMATINIB; LOW MOLECULAR WEIGHT HEPARIN; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PLACEBO; SORAFENIB; SUNITINIB; TOPOTECAN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; WARFARIN; ANTINEOPLASTIC AGENT; HYBRID PROTEIN; MONOCLONAL ANTIBODY;

EID: 77952314572     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(09)70362-6     Document Type: Review
Times cited : (74)

References (108)
  • 1
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • Cannistra SA, Matulonis UA, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007, 25:5180-5186.
    • (2007) J Clin Oncol , vol.25 , pp. 5180-5186
    • Cannistra, S.A.1    Matulonis, U.A.2    Penson, R.T.3
  • 2
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study
    • Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007, 25:5165-5171.
    • (2007) J Clin Oncol , vol.25 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 3
    • 33745923690 scopus 로고    scopus 로고
    • Salvage bevacizumab (rhuMAB VEGF)-based therapy after multiple prior cytotoxic regimens in advanced refractory epithelial ovarian cancer
    • Monk BJ, Han E, Josephs-Cowan CA, Pugmire G, Burger RA Salvage bevacizumab (rhuMAB VEGF)-based therapy after multiple prior cytotoxic regimens in advanced refractory epithelial ovarian cancer. Gynecol Oncol 2006, 102:140-144.
    • (2006) Gynecol Oncol , vol.102 , pp. 140-144
    • Monk, B.J.1    Han, E.2    Josephs-Cowan, C.A.3    Pugmire, G.4    Burger, R.A.5
  • 4
    • 2442696436 scopus 로고    scopus 로고
    • Prognostic importance of comorbidity in a hospital-based cancer registry
    • Piccirillo JF, Tierney RM, Costas I, Grove L, Spitznagel EL Prognostic importance of comorbidity in a hospital-based cancer registry. JAMA 2004, 291:2441-2447.
    • (2004) JAMA , vol.291 , pp. 2441-2447
    • Piccirillo, J.F.1    Tierney, R.M.2    Costas, I.3    Grove, L.4    Spitznagel, E.L.5
  • 5
    • 36849054884 scopus 로고    scopus 로고
    • Safety of maintenance bevacizumab after first-line chemotherapy for advanced ovarian and müllerian cancers
    • abstr 5517.
    • Campos SM, Dizon DS, Cannistra SA, et al. Safety of maintenance bevacizumab after first-line chemotherapy for advanced ovarian and müllerian cancers. Proc Am Soc Clin Oncol 2007, 25. abstr 5517.
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Campos, S.M.1    Dizon, D.S.2    Cannistra, S.A.3
  • 6
    • 34447298651 scopus 로고    scopus 로고
    • A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer
    • Micha JP, Goldstein BH, Rettenmaier MA, et al. A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. Int J Gynecol Cancer 2007, 17:771-776.
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 771-776
    • Micha, J.P.1    Goldstein, B.H.2    Rettenmaier, M.A.3
  • 7
    • 33947304431 scopus 로고    scopus 로고
    • Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors
    • abstr 5020.
    • Penson RT, Cannistra SA, Seiden MV, et al. Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors. Proc Am Soc Clin Oncol 2006, 24. abstr 5020.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Penson, R.T.1    Cannistra, S.A.2    Seiden, M.V.3
  • 8
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 9
    • 67649364437 scopus 로고    scopus 로고
    • Phase II prospective study of weekly topotecan and bevacizumab in platinum refractory ovarian cancer or peritoneal cancer (OC)
    • abstr 5551.
    • McGonigle KF, Muntz HG, Vuky JL, et al. Phase II prospective study of weekly topotecan and bevacizumab in platinum refractory ovarian cancer or peritoneal cancer (OC). Proc Am Soc Clin Oncol 2008, 26. abstr 5551.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • McGonigle, K.F.1    Muntz, H.G.2    Vuky, J.L.3
  • 10
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
    • Garcia AA, Hirte H, Fleming G, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol 2008, 26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 11
    • 56449105264 scopus 로고    scopus 로고
    • Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer
    • Richardson DL, Backes FJ, Seamon LG, et al. Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer. Gynecol Oncol 2008, 111:461-466.
    • (2008) Gynecol Oncol , vol.111 , pp. 461-466
    • Richardson, D.L.1    Backes, F.J.2    Seamon, L.G.3
  • 12
    • 45549099056 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia
    • Nimeiri HS, Oza AM, Morgan RJ, et al. Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 2008, 110:49-55.
    • (2008) Gynecol Oncol , vol.110 , pp. 49-55
    • Nimeiri, H.S.1    Oza, A.M.2    Morgan, R.J.3
  • 13
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad NS, Posadas EM, Kwitkowski VE, et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008, 26:3709-3714.
    • (2008) J Clin Oncol , vol.26 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 14
    • 36849005801 scopus 로고    scopus 로고
    • VEGF-Trap for patients (pts) with recurrent platinum-resistant epithelial ovarian cancer (EOC): preliminary results of a randomized, multicenter phase II study
    • abstr 5508.
    • Tew WP, Colombo N, Ray-Coquard I, et al. VEGF-Trap for patients (pts) with recurrent platinum-resistant epithelial ovarian cancer (EOC): preliminary results of a randomized, multicenter phase II study. Proc Am Soc Clin Oncol 2007, 25. abstr 5508.
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Tew, W.P.1    Colombo, N.2    Ray-Coquard, I.3
  • 15
    • 69849111795 scopus 로고    scopus 로고
    • Aflibercept in epithelial ovarian carcinoma
    • Moroney J, Sood AK, Coleman RL Aflibercept in epithelial ovarian carcinoma. Future Oncol 2009, 5:591-600.
    • (2009) Future Oncol , vol.5 , pp. 591-600
    • Moroney, J.1    Sood, A.K.2    Coleman, R.L.3
  • 16
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies
    • Hutson TE, Figlin RA, Kuhn JG, Motzer RJ Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 2008, 13:1084-1096.
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3    Motzer, R.J.4
  • 17
    • 35549013184 scopus 로고    scopus 로고
    • Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects
    • Kollmannsberger C, Soulieres D, Wong R, Scalera A, Gaspo R, Bjarnason G Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects. Can Urol Assoc J 2007, 1(suppl 2):41-54.
    • (2007) Can Urol Assoc J , vol.1 , Issue.SUPPL. 2 , pp. 41-54
    • Kollmannsberger, C.1    Soulieres, D.2    Wong, R.3    Scalera, A.4    Gaspo, R.5    Bjarnason, G.6
  • 18
    • 58149248099 scopus 로고    scopus 로고
    • A phase II study of sunitinib (SU11248) in patients (pts) with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma-NCIC CTG IND 185
    • abstr 5522.
    • Biagi JJ, Oza AM, Grimshaw R, et al. A phase II study of sunitinib (SU11248) in patients (pts) with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma-NCIC CTG IND 185. Proc Am Soc Clin Oncol 2008, 26. abstr 5522.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Biagi, J.J.1    Oza, A.M.2    Grimshaw, R.3
  • 19
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D, Richly H, Hilger RA, et al. Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005, 23:965-972.
    • (2005) J Clin Oncol , vol.23 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 20
    • 58149225750 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): a Gynecologic Oncology Group (GOG) study
    • abstr 5537.
    • Matei D, Sill MW, DeGeest K, Bristow RE Phase II trial of sorafenib in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): a Gynecologic Oncology Group (GOG) study. Proc Am Soc Clin Oncol 2008, 26. abstr 5537.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Matei, D.1    Sill, M.W.2    DeGeest, K.3    Bristow, R.E.4
  • 21
    • 33846206208 scopus 로고    scopus 로고
    • Phase II study of sorafenib (BAY 43-9006) in combination with gemcitabine in recurrent epithelial ovarian cancer: a PMH phase II consortium trial
    • abstr 5084.
    • Welch S, Hirte H, Schilder RJ, et al. Phase II study of sorafenib (BAY 43-9006) in combination with gemcitabine in recurrent epithelial ovarian cancer: a PMH phase II consortium trial. Proc Am Soc Clin Oncol 2006, 24. abstr 5084.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Welch, S.1    Hirte, H.2    Schilder, R.J.3
  • 22
    • 36549038661 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: initial results of a phase II study
    • abstr 5561.
    • Friedlander M, Hancock KC, Benigno B, et al. Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: initial results of a phase II study. Proc Am Soc Clin Oncol 2007, 25. abstr 5561.
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Friedlander, M.1    Hancock, K.C.2    Benigno, B.3
  • 23
    • 58149257819 scopus 로고    scopus 로고
    • Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer
    • abstr 5501.
    • Matulonis UA, Berlin ST, Krasner CN, et al. Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer. Proc Am Soc Clin Oncol 2008, 26. abstr 5501.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Matulonis, U.A.1    Berlin, S.T.2    Krasner, C.N.3
  • 24
    • 58149219264 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial
    • abstr 5521.
    • Hirte HW, Vidal L, Fleming GF, et al. A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial. Proc Am Soc Clin Oncol 2008, 26. abstr 5521.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3
  • 25
    • 58149257819 scopus 로고    scopus 로고
    • Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer
    • abstr 5501.
    • Matulonis UA, Berlin ST, Krasner CN, et al. Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer. Proc Am Soc Clin Oncol 2008, 26. abstr 5501.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Matulonis, U.A.1    Berlin, S.T.2    Krasner, C.N.3
  • 26
    • 0003318990 scopus 로고    scopus 로고
    • Dose finding study of SU6668 given thrice daily by oral route under fed conditions in patients with advanced malignancies
    • abstr 437.
    • Kuenen B, Ruijter R, Hoekman K, et al. Dose finding study of SU6668 given thrice daily by oral route under fed conditions in patients with advanced malignancies. Proc Am Soc Clin Oncol 2002, 21. abstr 437.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kuenen, B.1    Ruijter, R.2    Hoekman, K.3
  • 27
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005, 16:1391-1397.
    • (2005) Ann Oncol , vol.16 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3
  • 28
    • 60749137451 scopus 로고    scopus 로고
    • Beyond chemotherapy: targeted therapies in ovarian cancer
    • Yap TA, Carden CP, Kaye SB Beyond chemotherapy: targeted therapies in ovarian cancer. Nat Rev Cancer 2009, 9:167-181.
    • (2009) Nat Rev Cancer , vol.9 , pp. 167-181
    • Yap, T.A.1    Carden, C.P.2    Kaye, S.B.3
  • 29
    • 0038575250 scopus 로고    scopus 로고
    • Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • Jameson MB, Thompson PI, Baguley BC, et al. Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Br J Cancer 2003, 88:1844-1850.
    • (2003) Br J Cancer , vol.88 , pp. 1844-1850
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 30
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati A, Robertson K, Cooney M, et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 2002, 62:3408-3416.
    • (2002) Cancer Res , vol.62 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 31
    • 0038576231 scopus 로고    scopus 로고
    • 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study
    • Rustin GJ, Bradley C, Galbraith S, et al. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. Br J Cancer 2003, 88:1160-1167.
    • (2003) Br J Cancer , vol.88 , pp. 1160-1167
    • Rustin, G.J.1    Bradley, C.2    Galbraith, S.3
  • 32
    • 20044395276 scopus 로고    scopus 로고
    • Phase I trial of combretastatin a-4 phosphate with carboplatin
    • Bilenker JH, Flaherty KT, Rosen M, et al. Phase I trial of combretastatin a-4 phosphate with carboplatin. Clin Cancer Res 2005, 11:1527-1533.
    • (2005) Clin Cancer Res , vol.11 , pp. 1527-1533
    • Bilenker, J.H.1    Flaherty, K.T.2    Rosen, M.3
  • 33
    • 70149102260 scopus 로고    scopus 로고
    • Results from a phase 1/2 study of volociximab in combination with liposomal doxorubicin in relapsed advanced epithelial ovarian and primary peritoneal carcinoma
    • abstr 16527.
    • Delmonte A, Del Conte G, Sessa C, et al. Results from a phase 1/2 study of volociximab in combination with liposomal doxorubicin in relapsed advanced epithelial ovarian and primary peritoneal carcinoma. Proc Am Soc Clin Oncol 2008, 26. abstr 16527.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Delmonte, A.1    Del Conte, G.2    Sessa, C.3
  • 34
    • 0002790798 scopus 로고    scopus 로고
    • Phase I study of vitaxin, an anti-angiogenic humanized monoclonal antibody to vascular integrin avB3
    • abstr 832.
    • Gutheil JC, Campbell TN, Pierce PR, et al. Phase I study of vitaxin, an anti-angiogenic humanized monoclonal antibody to vascular integrin avB3. Proc Am Soc Clin Oncol 1998, 17. abstr 832.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Gutheil, J.C.1    Campbell, T.N.2    Pierce, P.R.3
  • 35
    • 34547683305 scopus 로고    scopus 로고
    • Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?
    • van Heeckeren WJ, Ortiz J, Cooney MM, Remick SC Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?. J Clin Oncol 2007, 25:2993-2995.
    • (2007) J Clin Oncol , vol.25 , pp. 2993-2995
    • van Heeckeren, W.J.1    Ortiz, J.2    Cooney, M.M.3    Remick, S.C.4
  • 36
    • 62949129110 scopus 로고    scopus 로고
    • Intricacies of bevacizumab-induced toxicities and their management
    • Gressett SM, Shah SR Intricacies of bevacizumab-induced toxicities and their management. Ann Pharmacother 2009, 43:490-501.
    • (2009) Ann Pharmacother , vol.43 , pp. 490-501
    • Gressett, S.M.1    Shah, S.R.2
  • 37
    • 43449107359 scopus 로고    scopus 로고
    • A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer
    • Wright JD, Secord AA, Numnum TM, et al. A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer. Int J Gynecol Cancer 2008, 18:400-406.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 400-406
    • Wright, J.D.1    Secord, A.A.2    Numnum, T.M.3
  • 38
    • 35348904080 scopus 로고    scopus 로고
    • Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer
    • Chura JC, Van Iseghem K, Downs LS, Carson LF, Judson PL Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Gynecol Oncol 2007, 107:326-330.
    • (2007) Gynecol Oncol , vol.107 , pp. 326-330
    • Chura, J.C.1    Van Iseghem, K.2    Downs, L.S.3    Carson, L.F.4    Judson, P.L.5
  • 39
    • 33845287895 scopus 로고    scopus 로고
    • Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: preliminary results of a multi-center phase II trial
    • abstr 5018.
    • Friberg G, Oza AM, Morgan RJ, Vokes EE, Gandara DR, Fleming GF Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: preliminary results of a multi-center phase II trial. Proc Am Soc Clin Oncol 2006, 24. abstr 5018.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Friberg, G.1    Oza, A.M.2    Morgan, R.J.3    Vokes, E.E.4    Gandara, D.R.5    Fleming, G.F.6
  • 40
    • 39149091246 scopus 로고    scopus 로고
    • Preliminary safety and efficacy results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube
    • abstr 5518.
    • Herzog TJ, Spirtos NM, Hines JF, et al. Preliminary safety and efficacy results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube. Proc Am Soc Clin Oncol 2007, 25. abstr 5518.
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Herzog, T.J.1    Spirtos, N.M.2    Hines, J.F.3
  • 42
    • 38149117040 scopus 로고    scopus 로고
    • Pneumatosis intestinalis: a variant of bevacizumab related perforation possibly associated with chemotherapy related GI toxicity
    • Asmis TR, Chung KY, Teitcher JB, Kelsen DP, Shah MA Pneumatosis intestinalis: a variant of bevacizumab related perforation possibly associated with chemotherapy related GI toxicity. Invest New Drugs 2008, 26:95-96.
    • (2008) Invest New Drugs , vol.26 , pp. 95-96
    • Asmis, T.R.1    Chung, K.Y.2    Teitcher, J.B.3    Kelsen, D.P.4    Shah, M.A.5
  • 43
    • 39149100500 scopus 로고    scopus 로고
    • Phase II study of intravenous (IV) and intraperitoneal (IP) paclitaxel (Tax), IP cisplatin (Cis), and IV bevacizumab (Bev) as first-line chemotherapy for optimal stage II or III ovarian, primary peritoneal, and fallopian tube cancer
    • Konner JA, Fallon K, Pezzuli S, et al. Phase II study of intravenous (IV) and intraperitoneal (IP) paclitaxel (Tax), IP cisplatin (Cis), and IV bevacizumab (Bev) as first-line chemotherapy for optimal stage II or III ovarian, primary peritoneal, and fallopian tube cancer. Proc Am Soc Clin Oncol 2007, 25:5523.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 5523
    • Konner, J.A.1    Fallon, K.2    Pezzuli, S.3
  • 44
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results
    • Rustin GJ, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 2003, 21:2815-2822.
    • (2003) J Clin Oncol , vol.21 , pp. 2815-2822
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 45
    • 76449086344 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate (CA4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: final phase II trial results
    • abstr 5502.
    • Zweifel M, Jayson G, Reed N, et al. Combretastatin A-4 phosphate (CA4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: final phase II trial results. Proc Am Soc Clin Oncol 2009, 27. abstr 5502.
    • (2009) Proc Am Soc Clin Oncol , vol.27
    • Zweifel, M.1    Jayson, G.2    Reed, N.3
  • 46
    • 33845313345 scopus 로고    scopus 로고
    • The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors: a review
    • Eskens FA, Verweij J The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors: a review. Eur J Cancer 2006, 42:3127-3139.
    • (2006) Eur J Cancer , vol.42 , pp. 3127-3139
    • Eskens, F.A.1    Verweij, J.2
  • 47
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A, et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2008, 26:1871-1878.
    • (2008) J Clin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 48
    • 65549122619 scopus 로고    scopus 로고
    • Management of hypertension in angiogenesis inhibitor-treated patients
    • Izzedine H, Ederhy S, Goldwasser F, et al. Management of hypertension in angiogenesis inhibitor-treated patients. Ann Oncol 2009, 20:807-815.
    • (2009) Ann Oncol , vol.20 , pp. 807-815
    • Izzedine, H.1    Ederhy, S.2    Goldwasser, F.3
  • 49
    • 38349030422 scopus 로고    scopus 로고
    • Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib
    • Porta C, Paglino C, Imarisio I, Bonomi L Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib. Clin Exp Med 2007, 7:127-134.
    • (2007) Clin Exp Med , vol.7 , pp. 127-134
    • Porta, C.1    Paglino, C.2    Imarisio, I.3    Bonomi, L.4
  • 50
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treated with bevacizumab combination therapy
    • Gordon MS, Cunningham D Managing patients treated with bevacizumab combination therapy. Oncology 2005, 69(suppl 3):25-33.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 51
    • 0038460302 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003, 289:2560-2572.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 52
    • 34447345394 scopus 로고    scopus 로고
    • Treatment of arterial hypertension (AHT) associated with angiogenesis inhibitors
    • Dirix LY, Maes H, Sweldens C Treatment of arterial hypertension (AHT) associated with angiogenesis inhibitors. Ann Oncol 2007, 18:1121-1122.
    • (2007) Ann Oncol , vol.18 , pp. 1121-1122
    • Dirix, L.Y.1    Maes, H.2    Sweldens, C.3
  • 54
    • 38049025794 scopus 로고    scopus 로고
    • Review: side effects of approved molecular targeted therapies in solid cancers
    • Widakowich C, de Castro G, de Azambuja E, Dinh P, Awada A Review: side effects of approved molecular targeted therapies in solid cancers. Oncologist 2007, 12:1443-1455.
    • (2007) Oncologist , vol.12 , pp. 1443-1455
    • Widakowich, C.1    de Castro, G.2    de Azambuja, E.3    Dinh, P.4    Awada, A.5
  • 55
    • 63849209812 scopus 로고    scopus 로고
    • Optimal management of emergent hypertension during treatment with a VEGF signaling inhibitor: a randomized phase II study of cediranib
    • abstr 3555.
    • Langenberg M, van Herpen CM, De Bono JS, et al. Optimal management of emergent hypertension during treatment with a VEGF signaling inhibitor: a randomized phase II study of cediranib. Proc Am Soc Clin Oncol 2008, 26. abstr 3555.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Langenberg, M.1    van Herpen, C.M.2    De Bono, J.S.3
  • 56
    • 0032589378 scopus 로고    scopus 로고
    • VEGF(165) mediates glomerular endothelial repair
    • Ostendorf T, Kunter U, Eitner F, et al. VEGF(165) mediates glomerular endothelial repair. J Clin Invest 1999, 104:913-923.
    • (1999) J Clin Invest , vol.104 , pp. 913-923
    • Ostendorf, T.1    Kunter, U.2    Eitner, F.3
  • 57
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008, 358:1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 58
    • 55949101031 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: can promising new therapy associated with cardiac toxicity strengthen the concept of teamwork?
    • Lenihan DJ Tyrosine kinase inhibitors: can promising new therapy associated with cardiac toxicity strengthen the concept of teamwork?. J Clin Oncol 2008, 26:5154-5155.
    • (2008) J Clin Oncol , vol.26 , pp. 5154-5155
    • Lenihan, D.J.1
  • 59
    • 0036498781 scopus 로고    scopus 로고
    • Cardiac dysfunction in the trastuzumab clinical trials experience
    • Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 2002, 20:1215-1221.
    • (2002) J Clin Oncol , vol.20 , pp. 1215-1221
    • Seidman, A.1    Hudis, C.2    Pierri, M.K.3
  • 60
    • 36849023013 scopus 로고    scopus 로고
    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
    • Chu TF, Rupnick MA, Kerkela R, et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007, 370:2011-2019.
    • (2007) Lancet , vol.370 , pp. 2011-2019
    • Chu, T.F.1    Rupnick, M.A.2    Kerkela, R.3
  • 61
    • 44649165869 scopus 로고    scopus 로고
    • Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor
    • Khakoo AY, Kassiotis CM, Tannir N, et al. Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer 2008, 112:2500-2508.
    • (2008) Cancer , vol.112 , pp. 2500-2508
    • Khakoo, A.Y.1    Kassiotis, C.M.2    Tannir, N.3
  • 62
    • 33745008604 scopus 로고    scopus 로고
    • Pathogenesis of cardiotoxicity induced by anthracyclines
    • Elliott P Pathogenesis of cardiotoxicity induced by anthracyclines. Semin Oncol 2006, 33(suppl 8):2-7.
    • (2006) Semin Oncol , vol.33 , Issue.SUPPL. 8 , pp. 2-7
    • Elliott, P.1
  • 63
    • 34247480545 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
    • Force T, Krause DS, Van Etten RA Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 2007, 7:332-344.
    • (2007) Nat Rev Cancer , vol.7 , pp. 332-344
    • Force, T.1    Krause, D.S.2    Van Etten, R.A.3
  • 64
    • 55949123335 scopus 로고    scopus 로고
    • Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
    • Schmidinger M, Zielinski CC, Vogl UM, et al. Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008, 26:5204-5212.
    • (2008) J Clin Oncol , vol.26 , pp. 5204-5212
    • Schmidinger, M.1    Zielinski, C.C.2    Vogl, U.M.3
  • 65
    • 1642494772 scopus 로고    scopus 로고
    • Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer
    • Cooney MM, Radivoyevitch T, Dowlati A, et al. Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer. Clin Cancer Res 2004, 10:96-100.
    • (2004) Clin Cancer Res , vol.10 , pp. 96-100
    • Cooney, M.M.1    Radivoyevitch, T.2    Dowlati, A.3
  • 67
    • 6044274062 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    • Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation 2004, 109:3122-3131.
    • (2004) Circulation , vol.109 , pp. 3122-3131
    • Yeh, E.T.1    Tong, A.T.2    Lenihan, D.J.3
  • 68
    • 36849063839 scopus 로고    scopus 로고
    • Structural reengineering of imatinib to decrease cardiac risk in cancer therapy
    • Demetri GD Structural reengineering of imatinib to decrease cardiac risk in cancer therapy. J Clin Invest 2007, 117:3650-3653.
    • (2007) J Clin Invest , vol.117 , pp. 3650-3653
    • Demetri, G.D.1
  • 69
    • 25144455894 scopus 로고    scopus 로고
    • Ovarian cancer and venous thromboembolic risk
    • Tateo S, Mereu L, Salamano S, et al. Ovarian cancer and venous thromboembolic risk. Gynecol Oncol 2005, 99:119-125.
    • (2005) Gynecol Oncol , vol.99 , pp. 119-125
    • Tateo, S.1    Mereu, L.2    Salamano, S.3
  • 70
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci FA, Skillings JR, Holden SN, et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007, 99:1232-1239.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 71
    • 33745308428 scopus 로고    scopus 로고
    • Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis
    • Wright JD, Hagemann A, Rader JS, et al. Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis. Cancer 2006, 107:83-89.
    • (2006) Cancer , vol.107 , pp. 83-89
    • Wright, J.D.1    Hagemann, A.2    Rader, J.S.3
  • 72
    • 33745069947 scopus 로고    scopus 로고
    • Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents
    • Holash J, Thurston G, Rudge JS, et al. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Rev 2006, 25:243-252.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 243-252
    • Holash, J.1    Thurston, G.2    Rudge, J.S.3
  • 73
    • 42949097505 scopus 로고    scopus 로고
    • Interim results from a phase II study of volociximab in combination with gemcitabine (GEM) in patients (pts) with metastatic pancreatic cancer (MPC)
    • abstr 142.
    • Evans T, Valle J, Berlin J, et al. Interim results from a phase II study of volociximab in combination with gemcitabine (GEM) in patients (pts) with metastatic pancreatic cancer (MPC). Gastrointestinal Cancers Symposium 2008, abstr 142.
    • (2008) Gastrointestinal Cancers Symposium
    • Evans, T.1    Valle, J.2    Berlin, J.3
  • 74
    • 33645549711 scopus 로고    scopus 로고
    • A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human alpha v beta 3 (avb3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma (MM)
    • abstr 7507.
    • Hersey P, Sosman J, O'Day S, et al. A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human alpha v beta 3 (avb3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma (MM). Proc Am Soc Clin Oncol 2005, 23. abstr 7507.
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Hersey, P.1    Sosman, J.2    O'Day, S.3
  • 76
    • 33645351051 scopus 로고    scopus 로고
    • Safety of low-dose aspirin (ASA) in a pooled analysis of 3 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy (CT) in patients (pts) with metastatic colorectal cancer (mCRC)
    • abstr 3554.
    • Hambleton J, Skillings J, Kabbinavar F, et al. Safety of low-dose aspirin (ASA) in a pooled analysis of 3 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy (CT) in patients (pts) with metastatic colorectal cancer (mCRC). Proc Am Soc Clin Oncol 2005, 23. abstr 3554.
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Hambleton, J.1    Skillings, J.2    Kabbinavar, F.3
  • 77
    • 18744380623 scopus 로고    scopus 로고
    • Bevacizumab does not increase bleeding in patients with metastatic colorectal cancer receiving concurrent anticoagulation
    • Hambleton J, Novotny WF, Hurwitz H Bevacizumab does not increase bleeding in patients with metastatic colorectal cancer receiving concurrent anticoagulation. Proc Am Soc Clin Oncol 2004, 22:3528.
    • (2004) Proc Am Soc Clin Oncol , vol.22 , pp. 3528
    • Hambleton, J.1    Novotny, W.F.2    Hurwitz, H.3
  • 78
    • 0037067889 scopus 로고    scopus 로고
    • Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study
    • Meyer G, Marjanovic Z, Valcke J, et al. Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med 2002, 162:1729-1735.
    • (2002) Arch Intern Med , vol.162 , pp. 1729-1735
    • Meyer, G.1    Marjanovic, Z.2    Valcke, J.3
  • 79
    • 0142121282 scopus 로고    scopus 로고
    • Bevacizumab, bleeding, thrombosis, and warfarin
    • Kilickap S, Abali H, Celik I Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003, 21:3542.
    • (2003) J Clin Oncol , vol.21 , pp. 3542
    • Kilickap, S.1    Abali, H.2    Celik, I.3
  • 80
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 81
    • 69249228874 scopus 로고    scopus 로고
    • A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: preliminary results
    • abstr 3556.
    • Limentani S, Just R, Purdham A, et al. A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: preliminary results. Proc Am Soc Clin Oncol 2008, 26. abstr 3556.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Limentani, S.1    Just, R.2    Purdham, A.3
  • 82
    • 37349055147 scopus 로고    scopus 로고
    • High frequency of intracerebral hemorrhage in metastatic renal carcinoma patients with brain metastases treated with tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptor
    • Pouessel D, Culine S High frequency of intracerebral hemorrhage in metastatic renal carcinoma patients with brain metastases treated with tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptor. Eur Urol 2008, 53:376-381.
    • (2008) Eur Urol , vol.53 , pp. 376-381
    • Pouessel, D.1    Culine, S.2
  • 83
    • 34547681379 scopus 로고    scopus 로고
    • Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • Drevs J, Siegert P, Medinger M, et al. Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007, 25:3045-3054.
    • (2007) J Clin Oncol , vol.25 , pp. 3045-3054
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 84
    • 33750344419 scopus 로고    scopus 로고
    • Risk factors for gastrointestinal perforations in patients with metastatic colorectal cancer receiving bevacizumab plus chemotherapy
    • abstr 3535.
    • Sugrue M, Kozloff M, Hainsworth J, et al. Risk factors for gastrointestinal perforations in patients with metastatic colorectal cancer receiving bevacizumab plus chemotherapy. Proc Am Soc Clin Oncol 2006, 24. abstr 3535.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Sugrue, M.1    Kozloff, M.2    Hainsworth, J.3
  • 85
    • 58749097799 scopus 로고    scopus 로고
    • Emergency surgery in the era of molecular treatment of solid tumours
    • Rutkowski P, Ruka W Emergency surgery in the era of molecular treatment of solid tumours. Lancet Oncol 2009, 10:157-163.
    • (2009) Lancet Oncol , vol.10 , pp. 157-163
    • Rutkowski, P.1    Ruka, W.2
  • 86
    • 33748999448 scopus 로고    scopus 로고
    • Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: updated results from a large observational registry in the US (BRiTE)
    • abstr 3536.
    • Hedrick E, Kozloff M, Hainsworth J, et al. Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: updated results from a large observational registry in the US (BRiTE). Proc Am Soc Clin Oncol 2006, 24. abstr 3536.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Hedrick, E.1    Kozloff, M.2    Hainsworth, J.3
  • 87
    • 69549140332 scopus 로고    scopus 로고
    • Aflibercept (VEGF Trap) for advanced epithelial ovarian cancer (EOC) patients (pts) with symptomatic malignant ascites: Preliminary results of a pilot study
    • abstr 14598.
    • Colombo N, Mangili G, Mammoliti S, et al. Aflibercept (VEGF Trap) for advanced epithelial ovarian cancer (EOC) patients (pts) with symptomatic malignant ascites: Preliminary results of a pilot study. Proc Am Soc Clin Oncol 2008, 26. abstr 14598.
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Colombo, N.1    Mangili, G.2    Mammoliti, S.3
  • 88
    • 67651146348 scopus 로고    scopus 로고
    • The risk of gastrointestinal perforation and/or fistula in patients with recurrent ovarian cancer receiving bevacizumab compared to standard chemotherapy: a retrospective cohort study
    • Sfakianos GP, Numnum TM, Halverson CB, Panjeti D, Kendrick JEt, Straughn JM The risk of gastrointestinal perforation and/or fistula in patients with recurrent ovarian cancer receiving bevacizumab compared to standard chemotherapy: a retrospective cohort study. Gynecol Oncol 2009, 114:424-426.
    • (2009) Gynecol Oncol , vol.114 , pp. 424-426
    • Sfakianos, G.P.1    Numnum, T.M.2    Halverson, C.B.3    Panjeti, D.4    Kendrick, J.5    Straughn, J.M.6
  • 89
    • 34648829056 scopus 로고    scopus 로고
    • Avoiding bevacizumab related gastrointestinal toxicity for recurrent ovarian cancer by careful patient screening
    • Simpkins F, Belinson JL, Rose PG Avoiding bevacizumab related gastrointestinal toxicity for recurrent ovarian cancer by careful patient screening. Gynecol Oncol 2007, 107:118-123.
    • (2007) Gynecol Oncol , vol.107 , pp. 118-123
    • Simpkins, F.1    Belinson, J.L.2    Rose, P.G.3
  • 92
    • 40149096054 scopus 로고    scopus 로고
    • Management of bevacizumab-associated bowel perforation: a case series and review of the literature
    • Badgwell BD, Camp ER, Feig B, et al. Management of bevacizumab-associated bowel perforation: a case series and review of the literature. Ann Oncol 2008, 19:577-582.
    • (2008) Ann Oncol , vol.19 , pp. 577-582
    • Badgwell, B.D.1    Camp, E.R.2    Feig, B.3
  • 93
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol 2005, 91:173-180.
    • (2005) J Surg Oncol , vol.91 , pp. 173-180
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3
  • 94
    • 33947311852 scopus 로고    scopus 로고
    • What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?
    • Han ES, Monk BJ What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?. Gynecol Oncol 2007, 105:3-6.
    • (2007) Gynecol Oncol , vol.105 , pp. 3-6
    • Han, E.S.1    Monk, B.J.2
  • 95
    • 33846780797 scopus 로고    scopus 로고
    • Lack of effect of starting bevacizumab shortly after venous access device implantation on wound healing/bleeding complications: preliminary results from first BEAT
    • abstr 245.
    • Berry S, Michael M, Kretzschmar A, et al. Lack of effect of starting bevacizumab shortly after venous access device implantation on wound healing/bleeding complications: preliminary results from first BEAT. Gastrointestinal Cancers Symposium 2006, abstr 245.
    • (2006) Gastrointestinal Cancers Symposium
    • Berry, S.1    Michael, M.2    Kretzschmar, A.3
  • 96
    • 68449095803 scopus 로고    scopus 로고
    • A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC)
    • abstr 5501.
    • Ledermann JA, Rustin GJ, Hackshaw A, et al. A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC). Proc Am Soc Clin Oncol 2009, 27. abstr 5501.
    • (2009) Proc Am Soc Clin Oncol , vol.27
    • Ledermann, J.A.1    Rustin, G.J.2    Hackshaw, A.3
  • 97
    • 20344362911 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
    • Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005, 92:1855-1861.
    • (2005) Br J Cancer , vol.92 , pp. 1855-1861
    • Awada, A.1    Hendlisz, A.2    Gil, T.3
  • 98
    • 39049121694 scopus 로고    scopus 로고
    • Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy
    • Yang CH, Lin WC, Chuang CK, et al. Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy. Br J Dermatol 2008, 158:592-596.
    • (2008) Br J Dermatol , vol.158 , pp. 592-596
    • Yang, C.H.1    Lin, W.C.2    Chuang, C.K.3
  • 99
    • 63149101547 scopus 로고    scopus 로고
    • Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy
    • Azad NS, Aragon-Ching JB, Dahut WL, et al. Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy. Clin Cancer Res 2009, 15:1411-1416.
    • (2009) Clin Cancer Res , vol.15 , pp. 1411-1416
    • Azad, N.S.1    Aragon-Ching, J.B.2    Dahut, W.L.3
  • 101
    • 33751242294 scopus 로고    scopus 로고
    • Leukocytoclastic vasculitis masquerading as hand-foot syndrome in a patient treated with sorafenib
    • Chung NM, Gutierrez M, Turner ML Leukocytoclastic vasculitis masquerading as hand-foot syndrome in a patient treated with sorafenib. Arch Dermatol 2006, 142:1510-1511.
    • (2006) Arch Dermatol , vol.142 , pp. 1510-1511
    • Chung, N.M.1    Gutierrez, M.2    Turner, M.L.3
  • 102
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol
    • Perez-Soler R, Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol, 23: 5235-46.
    • , vol.23 , pp. 5235-46
    • Perez-Soler R1    Saltz, L.2
  • 103
    • 38549142436 scopus 로고    scopus 로고
    • Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results
    • Boone SL, Rademaker A, Liu D, Pfeiffer C, Mauro DJ, Lacouture ME Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results. Oncology 2007, 72:152-159.
    • (2007) Oncology , vol.72 , pp. 152-159
    • Boone, S.L.1    Rademaker, A.2    Liu, D.3    Pfeiffer, C.4    Mauro, D.J.5    Lacouture, M.E.6
  • 104
    • 32444439875 scopus 로고    scopus 로고
    • Pooled safety analysis of BAY 43-9006 (sorafenib) monotherapy in patients with advanced solid tumours: is rash associated with treatment outcome?
    • Strumberg D, Awada A, Hirte H, et al. Pooled safety analysis of BAY 43-9006 (sorafenib) monotherapy in patients with advanced solid tumours: is rash associated with treatment outcome?. Eur J Cancer 2006, 42:548-556.
    • (2006) Eur J Cancer , vol.42 , pp. 548-556
    • Strumberg, D.1    Awada, A.2    Hirte, H.3
  • 105
    • 33846978108 scopus 로고    scopus 로고
    • Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib
    • Rini BI, Tamaskar I, Shaheen P, et al. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007, 99:81-83.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 81-83
    • Rini, B.I.1    Tamaskar, I.2    Shaheen, P.3
  • 106
    • 33750961647 scopus 로고    scopus 로고
    • Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors
    • Desai J, Yassa L, Marqusee E, et al. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006, 145:660-664.
    • (2006) Ann Intern Med , vol.145 , pp. 660-664
    • Desai, J.1    Yassa, L.2    Marqusee, E.3
  • 107
    • 55249116969 scopus 로고    scopus 로고
    • Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib
    • Billemont B, Medioni J, Taillade L, et al. Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib. Br J Cancer 2008, 99:1380-1382.
    • (2008) Br J Cancer , vol.99 , pp. 1380-1382
    • Billemont, B.1    Medioni, J.2    Taillade, L.3
  • 108
    • 66449133323 scopus 로고    scopus 로고
    • A change of strategy in the war on cancer
    • Gatenby RA A change of strategy in the war on cancer. Nature 2009, 459:508-509.
    • (2009) Nature , vol.459 , pp. 508-509
    • Gatenby, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.