Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-κB activation

International Journal of Radiation Biology

Volumn 89, Issue 5, 2013, Pages 371-377

  Park, Hyung Sun ^a   Seong, Ki Moon ^a   Kim, Ji Young ^a   Kim, Cha Soon ^a   Yang, Kwang Hee ^a   Jin, Young Woo ^a,b   Nam, Seon Young ^a  

^a Korea Hydro & Nuclear Power Co   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Adaptive response; AKT; Low dose radiation; Low dose rate; NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; RETROVIRUS VECTOR;

ARTICLE; CELL ASSAY; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LOW ENERGY RADIATION; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; THERAPY EFFECT; WESTERN BLOTTING;

CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; NF-KAPPA B; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS;

EID: 84877318403     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2013.754560     Document Type: Article

References (36)

1. Ahn JY, Rong R, Liu X, Ye K . 2004. PIKE/nuclear PI3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus . The EMBO Journal 23 : 3995 - 4006
2. Bellacosa A, Kumar CC, Di Cristofano A, Testa JR . 2005. Activation of AKT kinases in cancer: Implications for therapeutic targeting . Advances in Cancer Research 94: 29- 86
3. Buch K, Peters T, Nawroth T, Sänger M, Schmidberger H, Langguth P . 2012 . Determination of cell survival after irradiation via clonogenic assay versus multiple MTT assay - a comparative study . Radiation Oncology 7 : 1
4. Cai L 1999. Research of the adaptive response induced by low-dose radiation: Where have we been and where should we go? Human and Experimental Toxicology 18 : 419 - 425
5. Cai L, Jiang J . 1995. Mild hyperthermia can induce adaptation to cytogenetic damage caused by subsequent X-irradiation . Radiation Research 143: 26- 33
6. Cai L, Liu SZ . 1990 . Induction of cytogenetic adaptive response of somatic and germ cells in vitro and in vivo by low dose X-irradiation . International Journal of Radiation Biology 58 : 187 - 194
7. Cai L, Liu S . 1992 . Effect of cycloheximide on adaptive response induced by low-dose radiation . Biomedical and Environmental Sciences 5 : 46 - 52
8. Cai L, Wang P . 1995. Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic gamma-irradiation and its biological infl uence on radiationinduced DNA or chromosomal damage and cell killing in their male off spring . Mutagenesis 10: 95- 100
9. Calabrese EJ, Baldwin LA . 2003. Chemotherapeutics and hormesis . Critical Reviews in Toxicology 33: 305- 353
10. Calabrese EJ . 2004. Hormesis: From marginalization to mainstream: A case for hormesis as the default dose-response model in risk assessment . Toxicology and Applied Pharmacology 192: 125- 136
11. Choi KM, Kang CM, Cho ES, Kang SM, Lee SB, Um HD . 2007 . Ionizing radiation-induced micronucleus formation is mediated by reactive oxygen species that are produced in a manner dependent on mitochondria, Nox1, and JNK . Oncology Reports 17 : 1183 - 1188
12. Di Pietro R, Centurione L, Santavenere E, Centurione MA, Sanit à Di Toppi G, Zamai L, Rana R . 1996. Ionizing radiation-induced apoptosis and DNA repair in murine erythroleukemia cells . Scanning Microsccopy 10 : 253 - 259
13. Hayden MS, Ghosh S . 2004. Signaling to NF-kB. Genes and Development 18 : 2195 - 2224
14. Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K . 2005 . Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation . The EMBO Journal 24 : 3543 - 3554
15. Ina Y, Tanooka H, Yamada T, Sakai K . 2005. Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice . Radiation Research 163: 153- 158
16. Joiner MC, Lambin P, Malaise EP, Robson T, Arrand JE, Skov KA, Marples B . 1996 . Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance . Mutation Research 358: 171- 183
17. Krasilnikov M, Adler V, Fuchs SY, Dong Z, Haimovitz-Friedman A, Herlyn M, Ronai Z . 1999. Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells . Molecular Carcinogenesis 24 : 64 - 69
18. Lee BL, Lee HS, Jung J, Cho SJ, Chung HY, Kim WH, Jin YW, Kim CS, Nam SY . 2005. Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer . Clinical Cancer Research 11: 2518- 2525
19. Liang X, So YH, Cui J, Ma K, Xu X, Zhao Y, Cai L, Li W . 2011 . The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK/ERK pathway in rat cultured mesenchymal stem cells . Journal of Radiation Research 52: 380- 386
20. Liu G, Gong P, Zhao H, Wang Z, Gong S, Cai L . 2006. Effect of low-level radiation on the death of male germ cells . Radiation Research 165: 379- 389
21. Liu SZ, Liu WH, Sun JB . 1987 . Radiation hormesis: Its expression in the immune system . Health Physics 52: 579- 583
22. Liu SZ . 1989 . Radiation hormesis: A new concept in radiological science . Chinese Medical Journal 102: 750- 755
23. Luckey TD . 2006. Radiation hormesis: The good, the bad, and the ugly . Dose-Response: A publication of International Hormesis Society 4 : 169 - 190
24. Mishra KP . 2004. Cell membrane oxidative damage induced by gammaradiation and apoptotic sensitivity . Journal of Environmental Pathology, Toxicology and Oncology: Official organ of the International Society for Environmental Toxicology and Cancer 23: 61- 66
25. Mitchel RE, Burchart P, Wyatt H . 2008 . A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice . Radiation Research 170: 765- 775
26. Mitchel RE, Jackson JS, Morrison DP, Carlisle SM . 2003 . Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice . Radiation Research 159: 320- 327
27. Nam SY, Seo HH, Park HS, An S, Kim JY, Yang KH, Kim CS, Jeong M, Jin YW . 2010 . Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation . The Journal of Biological Chemistry 285 : 31157 - 31163
28. Olivieri G, Bodycote J, Wolff S . 1984. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine . Science (New York) 223 : 594 - 597
29. Park HS, Yun Y, Kim CS, Yang KH, Jeong M, Ahn SK, Jin YW, Nam SY . 2009 . A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression . European Journal of Cell Biology 88 : 563 - 575
30. Pollycove M, Feinendegen LE . 2003 . Radiation-induced versus endogenous DNA damage: Possible effect of inducible protective responses in mitigating endogenous damage . Human and Experimental Toxicology 22 : 290 - 306
31. Portess DI, Bauer G, Hill MA, O ' Neill P . 2007. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis . Cancer Research 67: 1246- 1253
32. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y . 1999. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation . Nature 401 : 168 - 173
33. Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA . 2004. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes . Circulation Research 94: 884- 891
34. Skov KA . 1999. Radioresponsiveness at low doses: Hyper-radiosensitivity and increased radioresistance in mammalian cells . Mutation Research 4 30: 2 41- 2 53
35. Wang ZB, Liu YQ, Zhang Y, Li Y, An XX, Xu H, Guo Y, Jin W, Jiang ZJ, Cui YF . 2007 . Reactive oxygen species, but not mitochondrial membrane potential, is associated with radiation-induced apoptosis of AHH-1 human lymphoblastoid cells . Cell Biology International 31 : 1353 - 1358
36. Yoshida N, Imada H, Kunugita N, Norimura T . 1993 . Low-dose radiation-induced adaptive survival response in mouse spleen T-lymphocytes in vivo . Journal of Radiation Research (Tokyo) 34 : 269 - 276