The impact of fractionation in SBRT: Analysis with the linear quadratic model and the universal survival curve model

Acta Oncologica

Volumn 52, Issue 5, 2013, Pages 902-909

  Wennberg, Berit ^a,b   Lax, Ingmar ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL SURVIVAL; HUMAN; LINEAR QUADRATIC MODEL; MODEL; NORMAL TISSUE COMPLICATION PROBABILITY; PRIORITY JOURNAL; PROBABILITY; RADIATION DOSE FRACTIONATION; STEREOTACTIC BODY RADIATION THERAPY; UNIVERSAL SURVIVAL CURVE MODEL; CANCER SIZE; CANCER SURVIVAL; ESOPHAGUS; HEART; RADIATION DOSE; RADIATION PNEUMONIA; SPINAL CORD; SURVIVAL RATE; TRACHEA;

CELL SURVIVAL; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; LINEAR MODELS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NEOPLASMS; RADIOSURGERY; SURVIVAL ANALYSIS;

EID: 84877315110     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2012.728292     Document Type: Article

References (18)

1. Lax I , Blomgren H, N äs lund I , S vanstr öm R . S tereotactic radiotherapy of malignancies in the abdomen . Methodological aspects. Acta Oncol 1994; 33: 677-83 .
2. Blomgren H, L ax I , N äs lund I , S vanstr öm R . S tereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator . Clinical experience of the fi rst thirtyone patients. Acta Oncol 1995; 34: 861-70 .
3. Baumann P , Nyman J , Hoyer M , Wennberg B , Gagliardi G , Lax I , et al . Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy . J Clin Oncol 2009; 27: 3290-6 .
4. Tse R V , H awkins M , L ockwood G , K im J J, C ummings B , Knox J , et al . Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma . J Clin Oncol 2008; 26: 657-64 .
5. Park C , P apiez L , Z hang S , S tory M , T immerman R D . Universal survival curve and single fraction equivalent dose: Useful tools in understanding potency of ablative radiotherapy . Int J Radiat Oncol Biol Phys 2008; 70: 847-52 .
6. P ark H J , G riffi n R J , H ui S , L evitt S H , S ong C W . R adiationinduced vascular damage in tumours: Implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS) . Radiat Res 2012; 177: 311-27 .
7. Carlson DJ , K eall PJ , L oo BW, C hen ZJ , B rown JM . H ypofractionation results in reduced cell kill compared to conventional fractionation for tumours with regions of hypoxia . Int J Radiat Oncol Biol Phys 2011; 79: 1188-95 .
8. Wennberg B M , B aumann P , G agliardi G , N yman J , D rugge N , Hoyer M , et al . NTCP modelling of lung toxicity after SBRT comparing the universal survival curve and the linear quadratic model for fractionation correction . Acta Oncol 2011; 50: 518-27 .
9. Thames H D , W ithers H R , P eters L J, F letcher G H . C hanges in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships . Int J Radiat Oncol Biol Phys 1982; 8: 219-26 .
10. RTOG 0618 A phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients witHoperable stage I/II non-small cell lung cancer . Available from: http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails. aspx?study-0618 [cited August 2012].
11. Kutcher GJ , B urman C . C alculation of complication probability factors for non-uniform normal tissue irradiation: The effective volume method . Int J Radiat Oncol Biol Phys 1989; 16: 1623-30 .
12. Lyman J T . C omplication probability as assessed from dosevolume histograms . Radiat Res Suppl 1985; 8: 13-9 .
13. Svedman C, S andstr öm P , P isa P , B lomgren H, L ax I , K ä lkner KM , et al . A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma . Acta Oncol 2006; 45: 870-5 .
14. Fuks Z , K olesnick R . E ngaging the vascular component of the tumor response . Cancer Cell 2005; 8: 89-91 .
15. Otsuka S , S hibamoto Y , I wata H , M urata R , S ugie C , I to M , et al . Compatibility of the linear-quadratic formalism and biologically effective dose concept to high-dose-pre-fraction irradiation in a murine tumor . Int J Radiat Oncol Biol Phys 2011; 81: 1538-43 .
16. Haasbeek C J, L agerwaard F J, S lotman B J, S enen S . O utcomes of stereotactic ablative radiotherapy for centrally located earlystage lung cancer . J Thorac Oncol 2011; 6: 2036-43 .
17. Astrahan M . S ome implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation . Med Phys 2008; 35: 4161-72 .
18. RTOG 0915 (NCCTG N0927). A randomized phase II study comparing 2 stereotactic body radiation therapy (SBRT) schedules for medically inoperable patients with stage I peripheral non-small cell lung cancer . Available from: http://www.rtog.org/ClinicalTrials/ProtocolTable/Study Details.aspx?study-0915 [cited August 2012].