Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

BMC Medical Genetics

Volumn 14, Issue 1, 2013, Pages

  Andiappan, Anand Kumar ^a,b   Nilsson, Daniel ^c,d   Halldén, Christer ^d   De Yun, Wang ^a   Säll, Torbjörn ^e   Cardell, Lars Olaf ^c   Tim, Chew Fook ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KRISTIANSTAD UNIVERSITY   (Sweden)

^e LUND UNIVERSITY   (Sweden)

Author keywords

Allergic rhinitis; Association; Asthma; Case control; Replication

Indexed keywords

ALLERGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 13; MEMBRANE PROTEIN; NPSR1 PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SENSITIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; ASTHMA; CASE-CONTROL STUDIES; CTLA-4 ANTIGEN; DNA REPLICATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME, HUMAN; GLUTATHIONE S-TRANSFERASE PI; HUMANS; INTERLEUKIN-13; MALE; PHENOTYPE; POLLEN; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; RHINITIS, ALLERGIC, SEASONAL; SEASONS; SINGAPORE; STATISTICS, NONPARAMETRIC;

EID: 84877307925     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-14-51     Document Type: Article

References (30)

1. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008, 63(Suppl 86):8-160.
2. van Beijsterveldt CE, Boomsma DI. Genetics of parentally reported asthma, eczema and rhinitis in 5-yr-old twins. Eur Respir J 2007, 29(3):516-521. 10.1183/09031936.00065706, 17215318.
3. Rasanen M, Laitinen T, Kaprio J, Koskenvuo M, Laitinen LA. Hay fever-a Finnish nationwide study of adolescent twins and their parents. Allergy 1998, 53(9):885-890. 10.1111/j.1398-9995.1998.tb03996.x, 9788691.
4. Nilsson D, Andiappan AK, Halldén C, Tim CF, Säll T, Wang DY, Cardell LO. Poor reproducibility of allergic rhinitis SNP associations. PLoS One in press.
5. Andiappan AK, Wang DY, Anantharaman R, Parate PN, Suri BK, Low HQ, Li Y, Zhao W, Castagnoli P, Liu J. Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. PLoS One 2011, 6(5):e19719. 10.1371/journal.pone.0019719, 3098846, 21625490.
6. Ramasamy A, Curjuric I, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol 2011, 128(5):996-1005. 10.1016/j.jaci.2011.08.030, 22036096.
7. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE. Replicating genotype-phenotype associations. Nature 2007, 447(7145):655-660. 10.1038/447655a, 17554299.
8. Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, Neukirch F. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004, 113(1):86-93. 10.1016/j.jaci.2003.10.010, 14713912.
9. Linneberg A, Nielsen NH, Frolund L, Madsen F, Dirksen A, Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002, 57(11):1048-1052. 10.1034/j.1398-9995.2002.23664.x, 12359002.
10. Sichletidis L, Markou S, Daskalopoulou E, Constantinidis T, Tsiotsios J, Pechlivanidis T. The prevalence of asthma and allergic rhinitis among children in Greece. Am J Respir Crit Care Med 1999, 159(3):A143-A143.
11. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006, 7(2):95-100. 10.1038/sj.gene.6364284, 16395390.
12. Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, Sylvia JS, Ziniti JP, Lange C, Celedon JC. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med 2009, 179(12):1084-1090. 10.1164/rccm.200812-1860OC, 2695495, 19264973.
13. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WOCM. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma. N Engl J Med 2010, 363(13):1211-1221. 10.1056/NEJMoa0906312, 20860503.
14. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011, 43(9):887-U103. 10.1038/ng.888, 3445408, 21804549.
15. Bryborn M, Halldén C, Säll T, Adner M, Cardell LO. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. Respir Res 2008, 9:29. 10.1186/1465-9921-9-29, 2335106, 18373864.
16. Bryborn M, Halldén C, Säll T, Cardell LO. CLC- a novel susceptibility gene for allergic rhinitis?. Allergy 2010, 65(2):220-228. 10.1111/j.1398-9995.2009.02141.x, 19650845.
17. Nilsson D, Andiappan AK, Halldén C, Yun WD, Säll T, Tim CF, Cardell LO. Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study. BMC Med Genet 2012, 13(1):66. 3459792, 22857391.
18. Anantharaman R, Chew FT. Validation of pooled genotyping on the Affymetrix 500 k and SNP6.0 genotyping platforms using the polynomial-based probe-specific correction. BMC Genet 2009, 10.
19. R Development Core Team R: A language and environment for statistical computing 2009, Vienna, Austria: R Foundation for Statistical Computing, R Development Core Team.
20. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575. 10.1086/519795, 1950838, 17701901.
21. Storey JD. A direct approach to false discovery rates. J R Stat Soc Series B Stat Methodol 2002, 64:479-498.
22. Neale BM, Sham PC. The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004, 75(3):353-362. 10.1086/423901, 1182015, 15272419.
23. Vergara C, Jimenez S, Acevedo N, Martinez B, Mercado D, Gusmao L, Rafaels N, Hand T, Barnes KC, Caraballo L. Association of G-protein-coupled receptor 154 with asthma and total IgE in a population of the Caribbean coast of Colombia. Clin Exp Allergy 2009, 39(10):1558-1568. 10.1111/j.1365-2222.2009.03311.x, 19624525.
24. Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A. Characterization of a common susceptibility locus for asthma-related traits. Science 2004, 304(5668):300-304. 10.1126/science.1090010, 15073379.
25. Kormann MSD, Carr D, Klopp N, Illig T, Leupold W, Fritzsch C, Weiland SK, von Mutius E, Kabesch M. G-protein-coupled receptor polymorphisms are associated with asthma in a large German population. Am J Respir Crit Care Med 2005, 171(12):1358-1362. 10.1164/rccm.200410-1312OC, 15764725.
26. Melen E, Bruce S, Doekes G, Kabesch M, Laitinen T, Lauener R, Lindgren CM, Riedler J, Scheynius A, van Hage-Hamsten M. Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma. Am J Respir Crit Care Med 2005, 171(10):1089-1095. 10.1164/rccm.200410-1317OC, 15710598.
27. Malerba G, Lindgren CM, Xumerle L, Kiviluoma P, Trabetti E, Laitinen T, Galavotti R, Pescollderungg L, Boner AL, Kere J. Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma. Clin Exp Allergy 2007, 37(1):83-89. 10.1111/j.1365-2222.2006.02615.x, 17210045.
28. Hersh CP, Raby BA, Soto-Quiros ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST. Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med 2007, 176(9):849-857. 10.1164/rccm.200704-592OC, 2048676, 17702965.
29. Feng Y, Hong X, Wang L, Jiang S, Chen C, Wang B, Yang J, Fang Z, Zang T, Xu X. G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population. J Allergy Clin Immunol 2006, 117(3):612-617. 10.1016/j.jaci.2005.11.045, 16522461.
30. Wu H, Romieu I, Sienra-Monge JJ, del Rio-Navarro BE, Burdett L, Yuenger J, Li H, Chanock SJ, London SJ. Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. Genes Immun 2008, 9(3):224-230. 10.1038/gene.2008.8, 2364725, 18340359.