Rapid detection of antibiotic-resistant organism carriage for infection prevention

Clinical Infectious Diseases

Volumn 56, Issue 11, 2013, Pages 1614-1620

  Diekema, Daniel J ^a   Pfaller, Michael A ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b JMI LABORATORIES   (United States)

Author keywords

antimicrobial resistance; infection prevention; surveillance

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; GRAM NEGATIVE BACTERIUM; HUMAN; INFECTION PREVENTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT ORGANISM; PRIORITY JOURNAL; RAPID TEST; TURNAROUND TIME;

ANTIMICROBIAL RESISTANCE; INFECTION PREVENTION; SURVEILLANCE;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS;

EID: 84877297723     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit038     Document Type: Article

References (53)

1. Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48:1-12.
2. Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis 2008; 197:1079-81.
3. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29:996-1011.
4. Klevens RM, Morrison MA, Nadle J, et al. Invasive MRSA infections in the United States. JAMA 2007; 298:1763-71.
5. Siegel JD, Rhinehart E, Jackson M, et al. Management of MDROs in healthcare settings, 2006. Available at: www.cdc.gov/hicpac/pdf/MDRO/ MDROGuideline2006.pdf. Accessed 22 January 2013.
6. Robiscek J, Beaumont JL, Paule SM, et al. Universal surveillance for MRSA in 3 affiliated hospitals. Ann Intern Med 2008; 148:409-18.
7. Ben-David D, Maor Y, Keller N, et al. Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resis-tant Klebsiella pneumoniae infection. Infect Control Hosp Epidemiol 2010; 31:620-26.
8. Salgado CD, Farr BM. What proportion of hospital patients colonized with MRSA are identified by clinical microbiological cultures? Infect Control Hosp Epidemiol 2006; 27:116-21.
9. Diekema DJ, Dodgson KJ, Sigurdardottir B, Pfaller MA. Rapid detection of antimicrobial-resistant organism carriage: an unmet clinical need. J Clin Microbiol 2004; 42:2879-83.
10. Carroll KC. Rapid diagnostics for MRSA: current status. Mol Diagn Ther 2008; 12:15-24.
11. Chambers HF. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev 1997; 10:781-91.
12. Diekema DJ, Pfaller MA, Schmitz FJ, et al. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 2001; 32: S114-32.
13. Huletsky A, Giroux R, Rossbach V, et al. New real-time PCR assay for rapid detection of MRSA directly from specimens containing a mixture of staphylococci. J Clin Microbiol 2004; 42:1875-84.
14. Donnio PY, et al. Partial excision of the chromosomal cassette containing methicillin resistance determinant results in methicillin susceptible Staphylococcus aureus. J Clin Microbiol 2005; 43:4191-3.
15. Arbefeville SS, Zhang K, Kroeger JS, Howard WJ, Diekema DJ, Richter SS. Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay. J Clin Microbiol 2011; 49:2996-9.
16. Malhotra-Kumar S, Van Heirstraeten L, Lee A, Abrahantes JC, et al. Evaluation of molecular assays for rapid detection of MRSA. J Clin Microbiol 2010; 48:4598-601.
17. Gray J, Patel M, Turner H, Reynolds F. MRSA screening on a paediat-ric intensive care unit. Arch Dis Child 2012; 97:243-44.
18. Herdman MT, Wyncoll D, Halligan E, Cliff PR, French G, Edgeworth JD. Clinical application of real-time PCR to screening critically ill and emergency care surgical patients for MRSA: a quantitative analytical study. J Clin Microbiol 2009; 47:4102-8.
19. Garcia-Alvarez L, Holden MT, Lindsay H, et al. Methicillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect Dis 2011; 11:595-603.
20. Shore AC, Deasy EC, Slickers P, et al. Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 MRSA. Antimicrob Agents Chemother 2011; 55:3765-73.
21. Ito T, Hiramatsu K, Tomasz A, et al. Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother 2012; 56:4997-99.
22. McDanel J, Murphy C, Diekema DJ, et al. Chlorhexidine and mupiro-cin susceptibility of MRSA from colonized nursing home residents. Antmicrob Agents Chemother 2013; 57:552-8.
23. Andrews JI, Fleener DK, Messer SA, Kroeger JA, Diekema DJ. Screening for Staphylococcus aureus carriage in pregnancy: usefulness of novel sampling and culture strategies. Am J Obstet Gynecol 2009; 201:396.e1-5.
24. Arthur M, Courvalin P. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother 1993; 37: 1563-71.
25. Donskey DJ, Chowdhry TK, Hecker MT, et al. Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients. N Engl J Med 2000; 343:1925-32.
26. Ballard SA, Grabsch EA, Johnson PD, Grayson ML. Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli. Antimicrob Agents Chemother 2005; 49:77-81.
27. Gazin M, Lammens C, Goossens H, et al. Evaluation of GeneOhm VanR and Xpert vanA/vanB molecular assays for the rapid detection of vancomycin-resistant enterococci. Eur J Clin Microbiol Infect Dis 2012; 31:273-6.
28. Graham M, Ballard SA, Grabsche EA, Johnson PD, Grayson ML. High rates of fecal carriage of nonenterococcal vanB in both children and adults. Antimicrob Agents Chemother 2008; 52:1195-97.
29. Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N Engl J Med 2010; 362:1804-13.
30. Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev 2009; 22:161-82.
31. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. CLSI document M100-S21. Wayne, PA: CLSI; 2011.
32. Livermore DM, Andrews JM, Hawkey PM, et al. Are susceptibility tests enough, or should laboratories still seek ESBLs and carbapene-mases directly? J Antimicrob Chemother 2012; 67:1569-77.
33. Polsfuss S, Bloemberg GV, Giger J, Meyer V, Hombach M. Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and CLSI screening parameters for the detection of extended-spectrum β-lactamase production in clinical Enterobacteria-ceae isolates. J Antimicrob Chemother 2012; 67:159-66.
34. Covington LE, Nasrallah H, Behta M, et al. New CLSI recommendations: practical implications of eliminating ESBL testing and implementing new MIC breakpoints for Enterobacteriaceae at a major teaching hospital. Abstr Soc Healthcare Epidemiol Am 2011. Annual Scientific Meeting 1-4 April 2011, Dallas, Texas. Abstract 632.
35. Bush K. Bench-to-bedside review: the role of beta-lactamases in antibiotic-resistant gram-negative infections. Crit Care 2010; 14:224.
36. Snitkin ES, Zelazny AM, Thomas PJ, et al. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012; 4:148ra116.
37. Singh K, Mangold KA, Wyant K, et al. Rectal screening for Klebsiella pneumonia carbapenemases: comparison of real-time PCR and culture using two selective screening agar plates. J Clin Microbiol 2012; 50:2596-600.
38. Richter SN, Frasson I, Biasolo MA, et al. Ultrarapid detection of blaKPC from perirectal and nasal swabs by use of real-time PCR. J Clin Microbiol 2012; 50:1718-20.
39. Naas T, Cuszon G, Bogaerts P, Glupczyncki Y, Nordmann P. Evaluation of a DNA microarray for rapid detection of TEM, SHV and CTX-M extended spectrum beta-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases. J Clin Microbiol 2011; 49:1608-13.
40. Harbarth S, Fankhauser C, Schrenzel J, et al. Universal screening for MRSA at hospital admission and nosocomial infection in surgical patients. JAMA 2008; 299:1149-57.
41. Huskins WC, Huckabee CM, O'Grady NP, et al. Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med 2011; 364:1407-18.
42. Peterson LR, Diekema DJ. To screen or not to screen for MRSA. J Clin Microbiol 2010; 48:683-9.
43. Peterson LR, Karchmer T, Tenover FC. Transmission of resistant bacteria in intensive care. N Engl J Med 2011; 365:761-65.
44. Polisena J, Chen S, Cimon K, McGill S, Forward K, Gardam M. Clinical effectiveness of rapid tests for MRSA in hospitalized patients: a systematic review. BMC Infect Dis 2011; 11:336.
45. Tacconelli E, De Angelis EG, de Waure C, et al. Rapid screening tests for MRSA at hospital admission: systematic review and meta-analysis. Lancet Infect Dis 2009; 9:546-54.
46. Aldeyab MA, Kearney MP, Hughese CM, et al. Can the use of rapid PCR screening method decrease the incidence of nosocomial MRSA? J Hosp Infect 2009; 71:22-8.
47. Hardy K, Price C, Szczepura A, et al. Reduction in the rate of MRSA acquisition in surgical wards by rapid screening for colonization: a prospective, cross-over study. Clin Microbiol Infect 2010; 16:333-9.
48. Jeyaratnam D, Whitty CJ, Phillips K, et al. Impact of rapid screening tests on acquisition of MRSA: cluster randomized crossover trial. BMJ 2008; 26:927-30.
49. Kypraios T, O'Neill PD, Huang SS, Rifas-Shiman SL, Cooper BS. Assessing the role of undetected colonization and isolation precautions in reducing MRSA transmission in ICUs. BMC Infec Dis 2010; 10:29.
50. Murthy A, DeAngelis G, Pittet D, Schrenzel J, Uchay I, Harbarth S. Cost-effectiveness of universal MRSA screening on admission to surgery. Clin Microbiol Infect 2010; 16:1747-53.
51. Olchanski N, Mathews C, Fusfeld L, Jarvis W. Assessment of the influence of test characteristics on the clinical and cost impacts of MRSA screening programs in US hospitals. Infect Control Hosp Epidemiol 2011; 32:250-7.
52. Wassenberg MW, Kluytmans J, Erdkamp S, et al. Costs and benefits of rapid screening of MRSA in ICUs: a prospective multicenter study. Crit Care 2012; 16:R22.
53. Morgan D, Diekema DJ, Sepkowitz K, Perencevich EP. Adverse outcomes associated with contact precautions: a review of the literature. Am J Infect Control 2009; 37:85-93.