Nanoaggregates based on new poly-hydroxyethyl-aspartamide copolymers for oral insulin absorption

Molecular Pharmaceutics

Volumn 10, Issue 5, 2013, Pages 1644-1654

  Licciardi, Mariano ^a   Pitarresi, Giovanna ^a,b   Cavallaro, Gennara ^a   Giammona, Gaetano ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b CNR   (Italy)

Author keywords

drug delivery; nanoaggregates; polyhydroxyethylaspartamide; protein oral delivery

Indexed keywords

BUTYLAMINE; CARBOXYL GROUP; CHYMOTRYPSIN A; COPOLYMER; CYSTEINE; INSULIN; LIGAND; POLY[N (2 HYDROXYETHYL)ASPARTAMIDE]; POLYMER; PROTEIN; SUCCINIC ANHYDRIDE; ALPHA,BETA-POLY((2-HYDROXYETHYL)-ASPARTAMIDE); DRUG CARRIER; NANOPARTICLE; PEPTIDE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BOND; COLLOID; CONTROLLED STUDY; DERIVATIZATION; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STABILITY; DYNAMIC LIGHT SCATTERING; ENZYME DEGRADATION; HYDROPHILICITY; HYDROPHOBICITY; HYPERGLYCEMIA; IN VIVO STUDY; LIGHT SCATTERING; MALE; MOLECULE; NONHUMAN; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; SYNTHESIS; TABLET FORMULATION; TURBIDIMETRY; ANIMAL; CHEMISTRY; INTESTINE ABSORPTION; MATERIALS TESTING; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; PROTEIN STABILITY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; DRUG CARRIERS; INSULIN; INTESTINAL ABSORPTION; MALE; MATERIALS TESTING; NANOPARTICLES; NANOTECHNOLOGY; PEPTIDES; PROTEIN STABILITY; RATS; RATS, WISTAR;

EID: 84877296362     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300226d     Document Type: Article

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