Effect of probiotic lozenges on inflammatory reactions and oral biofilm during experimental gingivitis

Acta Odontologica Scandinavica

Volumn 71, Issue 3-4, 2013, Pages 828-833

  Hallström, Hadar ^a   Lindgren, Susann ^a   Yucel Lindberg, Tülay ^b   Dahlén, Gunnar ^c   Renvert, Stefan ^d   Twetman, Svante ^a,e  

^a Halland Hospital   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d KRISTIANSTAD UNIVERSITY   (Sweden)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Bacteriotherapy; Cytokines; Gingival crevicular fluid; Lactobacilli; Plaque

Indexed keywords

PLACEBO; PROBIOTIC AGENT;

ADULT; BIOFILM; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; GINGIVITIS; HUMAN; INFLAMMATION; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; ARTICLE; CONTROLLED CLINICAL TRIAL;

ADULT; BIOFILMS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GINGIVITIS; HUMANS; INFLAMMATION; PLACEBOS; PROBIOTICS;

EID: 84877262924     PISSN: 00016357     EISSN: 15023850     Source Type: Journal    
DOI: 10.3109/00016357.2012.734406     Document Type: Article

References (22)

1. WHO. Food and Agriculture Organization and World Health Organisation Expert Consultation. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Geneva: WHO; 2001.
2. de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008;111:1-66.
3. Teughels W, Loozen G, Quirynen M. Do probiotics offer opportunities to manipulate the periodontal oral microbiota? J Clin Periodontol 2011;38:159-77.
4. Krasse P, Carlsson B, Dahl C, Paulsson A, Nilsson A, Sinkiewicz G. Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed Dent J 2006;30: 55-60.
5. Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, et al. Improvement of periodontal conditionby probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol 2008;35:897-905.
6. Staab B, Eick S, Knofler G, Jentsch H. The influence of a probiotic milk drink on the development of gingivitis: a pilot study. J Clin Periodontol 2009;36:850-6.
7. Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, et al. Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2009;36:506-13.
8. Vivekananda MR, Vandana KL, Bhat KG. Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial. J Oral Microbiol 2010;2:1-9.
9. Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:201-8.
10. Twetman S, Derawi B, Keller M, Ekstrand K, Yucel- Lindberg T, Stecksen-Blicks C. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontol Scand 2009;67:19-24.
11. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965;36:177-87.
12. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.
13. Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. J Periodontol 1970;41:41-3.
14. Papapanou PN, Madianos PN, Dahlen G, Sandros J. "Checkerboard" versus culture: a comparison between two methods for identification of subgingival microbiota. Eur J Oral Sci 1997;105:389-96.
15. Dahlen G, Leonhardt A. A new checkerboard panel for testing bacterial markers in periodontal disease. Oral Microbiol Immunol 2006;21:6-11.
16. Trombelli L, Scapoli C, Orlandini E, Tosi M, Bottega S, Tatakis DN. Modulation of clinical expression of plaqueinduced gingivitis. III. Response of "high responders" and "lowresponders" to therapy. JClin Periodontol 2004;31:253-9.
17. Jonsson D, Ramberg P, Demmer RT, Kebschull M, Dahlen G, Papapanou PN. Gingival tissue transcriptomes in experimental gingivitis. J Clin Periodontol 2011;38: 599-611.
18. Offenbacher S, Barros S, Mendoza L, Mauriello S, Preisser J, Moss K, et al. Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. J Clin Periodontol 2010; 37:324-33.
19. Gracie JA, Robertson SE, McInnes IB. Interleukin-18. J Leukoc Biol 2003;73:213-24.
20. Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 2000;27:648-57.
21. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005;38:135-87.
22. Sinkiewicz G, Cronholm S, Ljunggren L, Dahlen G, Bratthall G. Influence of dietary supplementation with Lactobacillus reuteri on the oral flora of healthy subjects. Swed Dent J 2010;34:197-206.