-
1
-
-
84877297522
-
Large granular lymphocytic leukemia: Molecular pathogenesis, clinical manifestations, and treatment
-
Zhang D, Loughran TP Jr. Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment. Hematology Am. Soc. Hematol. Educ. Program 2012, 652-659 (2012
-
(2012)
Hematology Am. Soc. Hematol. Educ. Program
, vol.2012
, pp. 652-659
-
-
Zhang, D.1
Loughran Jr., T.P.2
-
2
-
-
55849100058
-
Network model of survival signaling in large granular lymphocyte leukemia
-
Zhang R, Shah MV, Yang J et al. Network model of survival signaling in large granular lymphocyte leukemia. Proc. Natl Acad. Sci. USA 105(42), 16308-16313 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.42
, pp. 16308-16313
-
-
Zhang, R.1
Shah, M.V.2
Yang, J.3
-
3
-
-
84867815120
-
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
-
Jerez A, Clemente MJ, Makishima H et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 120(15), 3057 (2012
-
(2012)
Blood
, vol.120
, Issue.15
, pp. 3057
-
-
Jerez, A.1
Clemente, M.J.2
Makishima, H.3
-
4
-
-
50949132631
-
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes
-
Shah MV, Zhang R, Irby R et al. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood 112(3), 770-781 (2008
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 770-781
-
-
Shah, M.V.1
Zhang, R.2
Irby, R.3
-
5
-
-
19944427271
-
ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL
-
Epling-Burnette PK, Bai F, Wei S et al. ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). Oncogene 23(57), 9229 (2004
-
(2004)
Oncogene
, vol.23
, Issue.57
, pp. 9229
-
-
Epling-Burnette, P.K.1
Bai, F.2
Wei, S.3
-
6
-
-
33751253427
-
Pathophysiology defined by altered signal transduction pathways: The role of JAK-STAT and PI3K signaling in leukemic large granular lymphocytes
-
Schade AE, Wlodarski MW, Maciejewski JP. Pathophysiology defined by altered signal transduction pathways: the role of JAK-STAT and PI3K signaling in leukemic large granular lymphocytes. Cell Cycle 5(22), 2571-2574 (2006
-
(2006)
Cell Cycle
, vol.5
, Issue.22
, pp. 2571-2574
-
-
Schade, A.E.1
Wlodarski, M.W.2
Maciejewski, J.P.3
-
7
-
-
84877279924
-
Results of a prospective multicenter Phase II study of initial treatment with methotrexate in LGL leukemia (ECOG protocol E5998
-
Loughran TP. Results of a prospective multicenter Phase II study of initial treatment with methotrexate in LGL leukemia (ECOG protocol E5998). Blood (ASH Annual Meeting Abstracts) 116(21).
-
Blood (ASH Annual Meeting Abstracts
, vol.116
, Issue.21
-
-
Loughran, T.P.1
-
8
-
-
70349651353
-
Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia
-
Mohan SR, Clemente MJ, Afable M et al. Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia. Haematologica 94(10), 1414 (2009
-
(2009)
Haematologica
, vol.94
, Issue.10
, pp. 1414
-
-
Mohan, S.R.1
Clemente, M.J.2
Afable, M.3
-
9
-
-
84872482913
-
Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-b-1 mAb in patients with T-cell large granular lymphocytic leukemia
-
Waldmann TA, Conlon KC, Stewart DM et al. Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-b-1 mAb in patients with T-cell large granular lymphocytic leukemia. Blood 121(3), 476-484 (2013
-
(2013)
Blood
, vol.121
, Issue.3
, pp. 476-484
-
-
Waldmann, T.A.1
Conlon, K.C.2
Stewart, D.M.3
-
10
-
-
0036888855
-
Regulation of lymphoid homeostasis by interleukin-15
-
Lodolce JP, Burkett PR, Koka RM, Boone DL, Aldo-Benson M.A. Regulation of lymphoid homeostasis by interleukin-15. Cytokine Growth Factor Rev. 13(6), 429-439 (2002
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, Issue.6
, pp. 429-439
-
-
Lodolce, J.P.1
Burkett, P.R.2
Koka, R.M.3
Boone, D.L.4
Aldo-Benson, M.A.5
-
11
-
-
84862921558
-
Increased serum soluble IL-15Ra levels in T-cell large granular lymphocyte leukemia
-
Chen J, Petrus M, Bamford R et al. Increased serum soluble IL-15Ra levels in T-cell large granular lymphocyte leukemia. Blood 119(1), 137-143 (2012
-
(2012)
Blood
, vol.119
, Issue.1
, pp. 137-143
-
-
Chen, J.1
Petrus, M.2
Bamford, R.3
-
12
-
-
0035807987
-
IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients
-
Azimi N, Nagai M, Jacobson S, Waldmann TA. IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients. Proc. Natl Acad. Sci. USA 98(25), 14559-14564 (2001
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, Issue.25
, pp. 14559-14564
-
-
Azimi, N.1
Nagai, M.2
Jacobson, S.3
Waldmann, T.A.4
-
13
-
-
31044434393
-
Preclinical and Phase i clinical trial of blockade of IL-15 using Mikb1 monoclonal antibody in T cell large granular lymphocyte leukemia
-
Morris JC, Janik JE, White JD et al. Preclinical and Phase I clinical trial of blockade of IL-15 using Mikb1 monoclonal antibody in T cell large granular lymphocyte leukemia. Proc. Natl Acad. Sci. USA 103(2), 401-406 (2006
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.2
, pp. 401-406
-
-
Morris, J.C.1
Janik, J.E.2
White, J.D.3
-
14
-
-
0027177881
-
Humanized Mik b 1, a humanized antibody to the IL-2 receptor b-chain that acts synergistically with humanized anti-TAC
-
Hakimi J, Ha VC, Lin P et al. Humanized Mik b 1, a humanized antibody to the IL-2 receptor b-chain that acts synergistically with humanized anti-TAC. J. Immunol. 151(2), 1075-1085 (1993
-
(1993)
J. Immunol
, vol.151
, Issue.2
, pp. 1075-1085
-
-
Hakimi, J.1
Ha, V.C.2
Lin, P.3
-
15
-
-
77952484146
-
Spontaneous findings in the heart of Mauritian-origin cynomolgus macaques (Macaca fascicularis
-
Vidal JD, Drobatz LS, Holliday DF, Geiger LE, Thomas HC. Spontaneous findings in the heart of Mauritian-origin cynomolgus macaques (Macaca fascicularis). Toxicol. Pathol. 38(2), 297-302 (2010
-
(2010)
Toxicol. Pathol
, vol.38
, Issue.2
, pp. 297-302
-
-
Vidal, J.D.1
Drobatz, L.S.2
Holliday, D.F.3
Geiger, L.E.4
Thomas, H.C.5
-
16
-
-
84869006006
-
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation
-
Mishra A, Liu S, Sams GH et al. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell 22(5), 645-655 (2012
-
(2012)
Cancer Cell
, vol.22
, Issue.5
, pp. 645-655
-
-
Mishra, A.1
Liu, S.2
Sams, G.H.3
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