Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 2, 2006, Pages 401-406

  Morris, John C ^a   Janik, John E ^a   White, Jeffrey D ^a   Fleisher, Thomas A ^b   Brown, Margaret ^b   Tsudo, Mitsuru ^c   Goldman, Carolyn K ^a   Bryant, Bonita ^a   Petrus, Michael ^a   Top, Lois ^a   Lee, Cathryn C ^a   Gao, Wendy ^a   Waldmann, Thomas A ^a,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c OSAKA RED CROSS HOSPITAL   (Japan)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cytokine; IL 2 IL 15 receptor (CD122); Natural killer cells

Indexed keywords

BILIRUBIN; INTERLEUKIN 15BETA RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MIKBETA1; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; CELL COUNT; CELL SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOPENIA; DISEASE ASSOCIATION; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG SPECIFICITY; DRUG USE; FEMALE; FEVER; HEMATOCYTOPENIA; HUMAN; HYPERBILIRUBINEMIA; LEUKEMIA CELL; MALE; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PATHOGENESIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RECEPTOR AFFINITY; T CELL LARGE GRANULAR LYMPHOCYTE LEUKEMIA; T CELL LEUKEMIA;

ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOCRINE COMMUNICATION; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-15; INTERLEUKIN-2; LEUKEMIA, T-CELL; MALE; MICE; MIDDLE AGED; PARACRINE COMMUNICATION; RECEPTORS, INTERLEUKIN-2; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 31044434393     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509575103     Document Type: Article

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