Evaluation of the possible protective role of quercetin on letrozole-induced testicular injury in Male Albino Rats

Ultrastructural Pathology

Volumn 37, Issue 3, 2013, Pages 204-217

  Selim, Manar E ^a,b   Aleisa, Nadia A ^a   Daghestani, Maha H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Ain Shams University   (Egypt)

Author keywords

Electron microscope; Sertoli; Testis

Indexed keywords

AROMATASE INHIBITOR; BIOLOGICAL MARKER; ESTRADIOL; FOLLITROPIN; LETROZOLE; LUTEINIZING HORMONE; NITRILE; PROTECTIVE AGENT; QUERCETIN; TESTOSTERONE; TRIAZOLE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; CELL PROTECTION; DOSE RESPONSE; DRUG EFFECT; MALE; METABOLISM; RAT; SERTOLI CELL; SPERMATOZOON; TESTIS; TIME; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; AROMATASE INHIBITORS; BIOLOGICAL MARKERS; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE; MALE; NITRILES; PROTECTIVE AGENTS; QUERCETIN; RATS; RATS, WISTAR; SERTOLI CELLS; SPERMATOZOA; TESTIS; TESTOSTERONE; TIME FACTORS; TRIAZOLES;

EID: 84877262449     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913123.2013.772269     Document Type: Article

References (55)

1. Haynes BP, Dowsett M, Miller WR, et al. The pharmacology of letrozole. J Steroid Biochem Mol Biol 2003;87: 35-45. (Pubitemid 37421337)
2. Zhou P, Shah B, Prasad K, David R. Letrozole significantly improves growth potential in a pubertal boy with growth hormone deficiency. J Am Acad Pediatr 2005;115: 245-8.
3. Santen RJ, Brodie H, Simpson ER, et al. History of aromatase: saga of an important biological mediator and therapeutic target. Endocrine Rev 2009;30: 343-75.
4. Patry G, Jarvi K, Grober ED, Lo KC. Use of the aromatase inhibitor letrozole to treat male infertility. Fertility Sterility 2009;92: 829e1-829e2.13-9-11.
5. Carreau S, De Vienne C, Galeraud-Denis I. Aromatase and estrogens in man reproduction: a review and latest advances. Adv Med Sci 2008;53: 139-44.
6. Carreau S, Delalande C, Galeraud-Denis I. Mammalian sperm quality and aromatase expression. Microsc Res Tech 2009;72: 552-7.
7. Carani C, Qin K, Simoni M, et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997;337: 91-105.
8. Hewitt SC, Harrell JC, Korach KS. Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol 2005;67: 285-308. (Pubitemid 40404493)
9. Takahama U. Scavenging of active oxygen by flavonoids. Tanpakushitsu Kakusan Koso 1988;33: 2994-9. 14-17 qucertin 2.
10. Rogerio AP, Kanashiro A, Fontanari C, et al. Antiinflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 2007; 56: 402-8. (Pubitemid 350160416)
11. Lamson DW, Brignall MS. Antioxidants and cancer, III: quercetin. Alternative Med Rev 2000;5: 196-208. (Pubitemid 30419042)
12. Youdim KA, Qaiser MZ, Begley DJ, et al. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radical Biol Med 2004;36: 592-604. (Pubitemid 38230176)
13. Inal ME, Akgun A, Kahraman A. Radioprotective effects of exogenous glutathione against whole-body gamma-ray irradiation: age-and gender-related changes in malondialdehyde levels, superoxide dismutase and catalase activities in rat liver. Methods Find Exp Clin Pharmacol 2002;24: 209-12. (Pubitemid 34606350)
14. Laughton MJ, Evans PJ, Moroney MA, et al. Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives: relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol 1991;42: 1673-81.
15. Tibon GM, Marottal F, Rossi C, Giampietro F. Effects of the aromatase inhibitor letrozole on in utero development in rats. Hum Reprod 2007;33: 1719-23.
16. Sun SW, Yu HQ, Zhang H, et al. Quercetin attenuates spontaneous behavior and spatial memory impairment in d-galactose-treated mice by increasing brain antioxidant capacity. Nutrition Res 2007;27: 169-75. (Pubitemid 46414045)
17. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990;36: 1440-3.
18. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70: 158-69.
19. Esterbaur H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hyroxynonenal. In: Packer L, Glazer AN. eds. Methods in Enzymology, vol. 186: Oxygen Radicals in Biological Systems. New York: Academic Press, 1990: 407-21. (Pubitemid 20279982)
20. Miller WR. Background and development of aromatase inhibitors. In: Furr BJA, ed. Aromatase Inhibitors. Berlin: Birkhauser, 2006:1-22.
21. Monnier A. Long-term efficacy and safety of letrozole for the adjuvant treatment of early breast cancer in postmenopausal women: a review. Ther Clin Risk Manag 2009;5: 725-38.
22. Nordman IC, Dalley DN. Breast cancer in men-should aromatase inhibitors become first-line hormonal treatment? Breast J 2008;14: 562-9.
23. Kumar H, Jayaraman M, Verma A, Modi KM. Letrozole as a booster therapy in growth hormone deficiency. Indian Pediatr 2009;46: 625-7.
24. Tiboni GM, Marotta F, Rossi C, Giampietro F. Effects of the aromatase inhibitor letrozole on in utero development in rats. Hum Reprod 2008;23: 1719-23. Abstract/FREE Full Text. (Pubitemid 352019997)
25. Li X, Strauss L, Makela S, et al. Multiple structural and functional abnormalities in the P450 aromatase expressing transgenic male mice are ameliorated by a P450 aromatase inhibitor. Am J Pathol 2004;164: 1039-48. (Pubitemid 38235485)
26. At-Taras EE, Berger T, McCarthy MJ, et al. Reducing estrogen synthesis in developing boars increases testis size and total sperm production. J Androl 2006;27: 552-9. (Pubitemid 44126268)
27. Rezvanfar MA, Ahmadi A, Shojaei HA, et al. Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological evidences for beneficial effect of pioglitazone. Hum Exp Toxicol 2012;31: 887-97.
28. Piotrowska K, Baranowska-Bosiacka I, Marchlewicz M, et al. Changes in male reproductive system and mineral metabolism induced by soy isoflavones administered to rats from prenatal life until sexual maturity. Nutrition 2011; 27: 372-9.
29. Martinez M, Macera S, De Assis GF, et al. Structural evaluation of the effects of chronic ethanol ingestion on the testis of Calomys callosus. Tissue Cell 2009;41: 199-205.
30. Sasso-Cerri E, Cerri P. Morphological evidences indicate that the interference of cimitidine on the peritubular components is responsible for detachment and apoptosis of Sertoli cells. Reprod Biol Endocrinol 2008;6: 18.
31. Hoffer AP. Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study. Biol Reprod 1983;28: 1007-20. (Pubitemid 13061782)
32. Vendramini V, Sasso-Cerri E, Miraglia SM. Amifostine reduces the seminiferous epithelium damage in doxorubicintreated prepubertal rats without improving the fertility status. Reprod Biol Endocrinol 2010;8: 3.
33. Tapanainen JS, Aittomaki K, Min J, et al. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet 1997;15: 205-206. (Pubitemid 27061645)
34. Carani C, Qin K, Simoni M, et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997;337: 91-5. (Pubitemid 27284394)
35. Haider SG, Passia D, Servos G, Hettwer H. Electron microscopic evidence for deep invaginations of the lamina propria towards the seminiferous tubule lumen in a patient with varicocele. Int J Androl 1986;9: 27-37. (Pubitemid 16059981)
36. Shirai T, Ikemoto I. Mechanism of alcoholic testicular damage. Nippon Hinyokika Gakkai Zasshi 1992;83: 305-14.
37. Kadota T, Chikazawa H, Takahashi N. Toxicological study of etoposide (VP-16) in rats with special emphasis on testicular alteration. Toxicol Lett 1989;45: 185-94. (Pubitemid 19047559)
38. Dym M. Basement membrane regulation of Sertoli cells. Endocr Rev 1994;15: 102-15. (Pubitemid 24058598)
39. Siu MK, Cheng CY. Extracellular matrix and its role in spermatogenesis. Adv Exp Med Biol 2008;636: 74-91.
40. Russell LD, Alger LF, Naquin LG. Hormonal control of pubertal spermatogenesis. Endocrinology 1987;120: 1615-32. PubMed Abstract. (Pubitemid 17054023)
41. Matsumoto AM, Bremner WJ. Endocrine control of human spermatogenesis. J Steroid Biochem 1989;33: 789-90. PubMed Abstract. (Pubitemid 20026157)
42. Kondarewicz A, Kolasa A, Zawiślak B, et al. Testis morphology in rats chronically treated with letrozole, an aromatase inhibitor. Folia Histochem Cytobiol 2011;49: 677-84.
43. Terman A, Brunk UT. Lipofuscin. Int J Biochem Cell Biol 2004;36: 1400-4. (Pubitemid 38625820)
44. Sampson N, Untergasser G, Plas E, Berger P. The ageing male reproductive tract. J Pathol 2007;211: 206-18. (Pubitemid 46195519)
45. Zitzmann M. Effects of testosterone replacement and its pharmacogenetics on physical performance and metabolism. Asian J Androl 2008;10: 364-72. (Pubitemid 351584112)
46. Wade AP, Wilkinson GS, Davis JC, Jeffcoate TN. The metabolism of testostrone, androstendione and oestrone by testes from a case of testicular feminization. J Endocrinol 1968;42: 391-403.
47. Codoner-Franch P, Tavarez-Alonso S, Murria-Estal R, et al. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 2011;215: 475-80.
48. Sharma R, Yang Y, Sharma A, et al. Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxidants Redox Signaling 2004;6: 289-300. (Pubitemid 38332586)
49. Aktoz T, Kanter M, Aktas C. Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats. Andrologia 2010;42: 376-83.
50. Van Voorhis B, Dunn M, Snyder G, Weiner C. Nitric oxide: an autocrine regulator of human granulosa-luteal cell steroidogenesis. Endocrinology 1994;135: 1799-806. (Pubitemid 24363869)
51. Seino T, Saito H, Kaneko T, et al. Eight-hydroxy-2'-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program. Fertil Steril 2002;77: 1184-90. (Pubitemid 34626327)
52. Chen JW, Zhu ZQ, Hu TX, Zhu DY. Structure-activity relationship of natural flavonoids in hydroxyl radicalscavenging effects. Acta Pharmacol Sin 2002;23: 667-72.
53. Firuzi O, Lacanna A, Petrucci R, et al. Evaluation of the antioxidant activityof flavonoids by "ferric reducing antioxidant power" assay and cyclic voltammetry. Biochim Biophys Acta 2005;1721: 174-84. (Pubitemid 40093525)
54. Mira L, Fernandez MT, Santos M, et al. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res 2002;36: 1199-208. (Pubitemid 35230240)
55. Anjaneyulu M, Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol 2004;31: 244-8. (Pubitemid 38507865)