Astrocytes shed large membrane vesicles that contain mitochondria, lipid droplets and ATP

Histochemistry and Cell Biology

Volumn 139, Issue 2, 2013, Pages 221-231

  Falchi, Angela Maria ^a   Sogos, Valeria ^a   Saba, Francesca ^a   Piras, Monica ^a   Congiu, Terenzio ^b   Piludu, Marco ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Astrocytes; ATP; Lipid droplets; Membrane vesicles; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA1 INTEGRIN; FAT DROPLET; LIPID;

ARTICLE; ASTROCYTE; FETUS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MEMBRANE VESICLE; MITOCHONDRION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; CYTOPLASM VESICLE; METABOLISM; PARTICLE SIZE;

ADENOSINE TRIPHOSPHATE; ASTROCYTES; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASMIC VESICLES; HUMANS; LIPIDS; MITOCHONDRIA; PARTICLE SIZE;

EID: 84877152972     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-012-1045-x     Document Type: Article

References (40)

1. Agnati LF, Guidolin D, Guescini M, Genedani S, Fuxe K (2010) Understanding wiring and volume transmission. Brain Res Rev 64:137-159
2. Bergersen LH, Gundersen V (2009) Morphological evidence for vesicular glutamate release from astrocytes. Neuroscience 158:260-265
3. Bianco F, Pravettoni E, Colombo A, Schenk U, Moller T, Matteoli M, Verderio C (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1β release from microglia. J Immunol 174:7268-7277
4. Bianco F, Perrotta C, Novellino L, Francolini M, Riganti L, Menna E, Saglietti L, Schuman EH, Furlan R, Clementi E, Matteoli M, Verderio C (2009) Acid spingomyelinase activity triggers microparticle release from glial cells. EMBO J 28:1043-1054
5. Bodin P, Burnstock G (2001) Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular. J Cardiovasc Pharmacol 38:900-908
6. Cabras S, Saba F, Reali C, Scorciapino ML, Sirigu A, Talani G, Biggio G, Sogos V (2010) Antidepressant imipramine induces human astrocytes to differentiate into cells with neuronal phenotype. Int J Neuropsychopharmacol 31:1-13
7. Coco S, Calegari F, Pravettoni E, Pozzi D, Taverna E, Rosa P, Matteoli M, Verderio C (2003) Storage and release of ATP from astrocytes in culture. J Biol Chem 278:1354-1362
8. Cocucci E, Racchetti G, Podini P, Meldolesi J (2007) Enlargeosome traffic: exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both. Traffic 8:742-757
9. Cocucci E, Racchetti G, Meldolesi J (2009) Shedding microvesicles: artefacts no more. Trends Cell Biol 19:43-51
10. Ducharme NA, Bickel PE (2008) Lipid droplets in lipogenesis and lipolysis. Endocrinology 149:942-949
11. Falchi AM, Battetta B, Sanna F, Piludu M, Sogos V, Serra M, Melis M, Putzolu M, Diaz G (2007) Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands. Neuropharmacology 53:318-329
12. Faurè J, Lachenal G, Court M et al (2006) Exosomes are resealed by cultured cortival neurones. Mol Cell Neurosci 31:642-648
13. Fellin T (2009) Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity. J Neurochem 108:533-544
14. Greenspan P, Mayer EP, Fowler SD (1985) Nile red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol 100:965-973
15. Guescini M, Genedani S, Stocchi V, Agnati LF (2010) Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J Neural Transm 117:1-4
16. György B, Szabó TG, Pásztói M, Pál Z, Misják P, Aradi B, László V, Pállinger É, Pap E, Kittel Á, Nagy G, Falus A, Buzá EI (2011) Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci 68:2667-2688
17. Hamilton NB, Attwell D (2010) Do astrocytes really exocytose neurotransmitters? Nat Rev Neurosci 11:227-238
18. Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, Bussolati B, Camussi G (2006) Isolation and characterization of a stem cell population from adult human liver. Stem Cells 24:2840-2850
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin-Phenol reagents. J Biol Chem 193:265-275
20. Martin S, Parton RG (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7:373-378
21. Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294:1354-1357
22. Medina JM, Tabernero A (2002) Astrocyte-synthesized oleic acid behaves as a neurotrophic factor for neurons. J Physiol Paris 96:265-271
23. Mulder M (2009) Sterols in the central nervous system. Curr Opin Clin Nutr Metab Care 12:152-158
24. Nieweg K, Schaller H, Pfrieger FW (2009) Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats. J Neurochem 109:125-134
25. Olofsson SO, Bostrom P, Andersson L, Rutberg M, Perman J, Borén J (2009) Lipid droplets as dynamic organelles connecting storage and efflux of lipids. Biochim Biophys Acta 1791:448-458
26. Pangrsic T, Potokar M, Stenovec M, Kreft M, Fabbretti E, Nistri A, Pryazhnikov E, Khiroug L, Giniatullin R, Zorec R (2007) Exocytotic release of ATP from cultured astrocytes. J Biol Chem 282:28749-28758
27. Pfrieger FW (2002) Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? BioEssays 25:72-78
28. Potokar M, Kreft M, Lee S-Y, Takano H, Haydon PG, Zorec R (2009) Trafficking of astrocytic vesicles in hippocampal slices. Biochem Biophys Res Commun 25:1192-1196
29. Proia P, Schiera G, Mineo M, Ingrassia AM, Santoro G, Savettieri G, Di Liegro I (2008) Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor. Int J Mol Med 21:63-67
30. Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ (2006) Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20:1487-1495
31. Robenek H, Robenek MJ, Troyer D (2005) PAT family proteins pervade lipid droplet cores. J Lipid Res 46:1331-1338
32. Sbai O, Ould-Yahoui A, Ferhat L, Gueye Y, Bernard A, Charrat E, Mehanna A, Risso JJ, Chauvin JP, Fenouillet E, Rivera S, Khrestchatisky M (2010) Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia 58:344-366
33. - cells in cell proliferation. J Neurosci Res 83:1515-1524
34. Spees JL, Olson SD, Whitney MJ, Prockop DJ (2006) Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci USA 103:1283-1288
35. Stevens B (2008) Neuron-astrocyte signaling in the development and plasticity of neural circuits. Neurosignals 16:278-288
36. 2+ oscillations and cell migration. Glia 55:652-662
37. Tabernero A, Lavado EM, Granda B, Velasco A, Medina JM (2001) Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes. J Neurochem 79:606-616
38. Taylor AR, Robinson MB, Gifondorwa DJ, Tytell M, Milligan CE (2007) Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases. Dev Neurobiol 67:1815-1829
39. Wang S, Cesca F, Loers G, Schweizer M, Buck F, Benfenati F, Schachner M, Kleene R (2011) Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes. J Neurosci 18:7275-7290
40. Xu J, Peng H, Kang N, Zhao Z, Lin J, Stanton PK, Kang J (2007) Glutamate-induced exocytosis of glutamate from astrocytes. J Biol Chem 282:24185-24197