Penetratin-mediated delivery enhances the antitumor activity of the cationic antimicrobial peptide magainin II

Cancer Biotherapy and Radiopharmaceuticals

Volumn 28, Issue 4, 2013, Pages 289-297

  Liu, Shan ^a   Yang, Hao ^a   Wan, Lin ^a   Cheng, Jingqiu ^a   Lu, Xiaofeng ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Cancer targeted therapy; Cationic antimicrobial peptide; Cell penetrating peptide

Indexed keywords

CHONDROITIN SULFATE; MAGAININ 2; MAGNESIUM ION; PENETRATIN; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CASPASE; DRUG CARRIER; MAGAININ 2 PEPTIDE, XENOPUS; MAGAININ DERIVATIVE; XENOPUS PROTEIN;

AGMK CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL KILLING; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG INHIBITION; GENE FUSION; GENE OVEREXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; MELANOMA SKIN CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SURFACE PROPERTY; TUMOR CELL; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA; ANIMAL; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHLOROCEBUS AETHIOPS; CYTOLOGY; DRUG EFFECTS; GLIOMA; HELA CELL LINE; IC50; KIDNEY PROXIMAL TUBULE; LUNG NEOPLASMS; MELANOMA; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; RAT; SKIN NEOPLASMS; VERO CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CARRIER PROTEINS; CASPASES; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM NEOPLASMS; CERCOPITHECUS AETHIOPS; CHONDROITIN SULFATES; DRUG CARRIERS; GLIOMA; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY TUBULES, PROXIMAL; LUNG NEOPLASMS; MAGAININS; MELANOMA; MOLECULAR TARGETED THERAPY; NEOPLASMS; RATS; SKIN NEOPLASMS; VERO CELLS; XENOPUS PROTEINS;

EID: 84877149624     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1328     Document Type: Article

References (32)

1. Mader JS, Hoskin DW. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin Investig Drugs 2006;15:933.
2. Hoskin D .W, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta Biomembr 2008;1778:357.
3. Schweizer F. Cationic amphiphilic peptides with cancerselective toxicity. Eur J Pharmacol 2009;625:190.
4. Riedl S, Zweytick D, Lohner K. Membrane-Active host defense peptides - challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids 2011;164:766.
5. Dobrzynska I, Szachowicz-Petelska B, Sulkowski S, et al. Changes in electric charge and phospholipids composition in human colorectal cancer cells. Mol Cell Biochem 2005; 276:113.
6. Yoon WH, Park HD, Lim K, et al. Effect of o-glycosylated mucin on invasion and metastasis of hm7 human colon cancer cells. Biochem Biophys Res Commun 1996;222:694.
7. Zachowski A. Phospholipids in animal eukaryotic membranes: Transverse asymmetry and movement. Biochem J 1993;294 (Pt 1):1.
8. Lehmann J, Retz M, Sidhu SS, et al. Antitumor activity of the antimicrobial peptide magainin ii against bladder cancer cell lines. Eur Urol 2006;50:141.
9. Paredes-Gamero EJ, Martins MNC, Cappabianco FAM, et al. Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption. J Pept Sci 2012;18:S59.
10. Zhang H-T, Wu J, Zhang H-f, et al. Efflux of potassium ion is an important reason of hl-60 cells apoptosis induced by tachyplesin. Acta Pharmacol Sin 2006;27:1367.
11. Chen Y-LS, Li J-H, Yu C-Y, et al. Novel cationic antimicrobial peptide gw-h1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines. Peptides 2012;36:257.
12. Zasloff M. Magainins, a class of antimicrobial peptides from xenopus skin: Isolation, characterization of two active forms, and partial cdna sequence of a precursor. PNAS 1987;84: 5449.
13. Baker MA, Maloy WL, Zasloff M, et al. Anticancer efficacy of magainin2 and analogue peptides. Cancer Res 1993;53:3052.
14. Matsuzaki K, Nakamura A, Murase O, et al. Modulation of magainin 2-lipid bilayer interactions by peptide charge. Biochemistry 1997;36:2104.
15. Liu S, Yang H, Wan L, et al. Enhancement of cytotoxicity of antimicrobial peptide magainin ii in tumor cells by bombesintargeted delivery. Acta Pharmacol Sin 2011;32:79.
16. Cai H, Yang H, Xiang B, et al. Selective apoptotic killing of solid and hematologic tumor cells by bombesin-Targeted delivery of mitochondria-disrupting peptides. Mol Pharmaceutics 2010;7:586.
17. Stewart KM, Horton KL, Kelley SO. Cell-penetrating peptides as delivery vehicles for biology and medicine. Org Biomol Chem 2008;6:2242.
18. Heitz F, Morris MC, Divita G. Twenty years of cellpenetrating peptides: From molecular mechanisms to therapeutics. Br J Pharmacol 2009;157:195.
19. Zhang WY, Smith SO. Mechanism of penetration of antp(43-58) into membrane bilayers. Biochemistry 2005;44:10110.
20. Bolhassani A. Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer. Biochim Biophys Acta Rev Cancer 2011;1816:232.
21. Yang H, Liu S, Cai H, et al. Chondroitin sulfate as a molecular portal that preferentially mediates the apoptotic killing of tumor cells by penetratin-directed mitochondriadisrupting peptides. J Biol Chem 2010;285:25666.
22. Evers TH, van Dongen EMWM, Faesen AC, et al. Quantitative understanding of the energy transfer between fluorescent proteins connected via flexible peptide linkers. Biochemistry 2006;45:13183.
23. Ricciardelli C, Sakko AJ, Ween MP, et al. The biological role and regulation of versican levels in cancer. Cancer Metastasis Rev 2009;28:233.
24. Ghibaudi E, Boscolo B, Inserra G, et al. The interaction of the cell-penetrating peptide penetratin with heparin, heparansulfates and phospholipid vesicles investigated by esr spectroscopy. J Pept Sci 2005;11:401.
25. Alves ID, Bechara C, Walrant A, et al. Relationships between membrane binding, affinity and cell internalization efficacy of a cell-penetrating peptide: Penetratin as a case study. PLoS One 2011;6:1.
26. Cruciani RA, Barker JL, Zasloff M, et al. Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. PNAS 1991;88:3792.
27. Westerhoff HV, Hendler RW, Zasloff M, et al. Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria. BBA 1989;975:361.
28. Cruz-Chamorro L, Puertollano MA, Puertollano E, et al. In vitro biological activities of magainin alone or in combination with nisin. Peptides 2006;27:1201.
29. Foerg C, Merkle HP. On the biomedical promise of cell penetrating peptides: Limits versus prospects. J Pharm Sci 2008;97:144.
30. Richter S, Bouvet V, Wuest M, et al. 18f-labeled phosphopeptide-cell- penetrating peptide dimers with enhanced cell uptake properties in human cancer cells. Nucl Med Biol 2012;39:1202.
31. Nakase I, Konishi Y, Ueda M, et al. Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo. J Controlled Release 2012;159:181.
32. Kondo E, Saito K, Tashiro Y, et al. Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems. Nat Commun 2012;3:951.