Korean mistletoe lectin promotes proliferation and invasion of trophoblast cells through regulation of Akt signaling

Reproductive Toxicology

Volumn 39, Issue , 2013, Pages 33-39

  Lyu, Su Yun ^a   Choi, Jong Ho ^b   Lee, Hyun Jung ^b   Park, Won Bong ^c   Kim, Gi Jin ^b  

^a Sunchon National University   (South Korea)

^b CHA University   (South Korea)

^c Seoul Women University   (South Korea)

Author keywords

Akt signaling pathway; Integrin; Invasion; Korean mistletoe lectin; Trophoblast

Indexed keywords

ALPHA5 INTEGRIN; BETA1 INTEGRIN; GELATINASE A; GELATINASE B; LECTIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; VISCUM ALBUM AGGLUTININ;

ARTICLE; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; KOREA; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TROPHOBLAST; UPREGULATION; VISCUM ALBUM;

CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT LECTINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TROPHOBLASTS; VISCUM ALBUM;

EID: 84877126974     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.03.011     Document Type: Article

References (53)

1. Büssing A., Suzart K., Bergmann J., Pfüller U., Schweizer K. Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Letters 1996, 109:33-39.
2. Franz H., Ziska P., Kindt A. Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochemical Journal 1981, 195:481-484.
3. Lyu S.Y., Park W.B. Mistletoe lectin (Viscum album coloratum) modulates proliferation and cytokine expressions in murine splenocytes. Journal of Biochemistry and Molecular Biology 2006, 39:662-670.
4. Lyu S.Y., Park W.B. Gene network analysis on the effect of Viscum album var. coloratum in T cells stimulated with anti-CD3/CD28 antibodies. Archives of Pharmacal Research 2011, 10:1735-1749.
5. Kim M.S., So H.S., Lee K.M., Park J.S., Lee J.H., Moon S.K., et al. Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells. General Pharmacology 2000, 34:349-355.
6. Pae H.O., Seo W.G., Shin M., Lee H.S., Kim S.B., Chung H.T. Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. coloratum, in the human leukemic HL-60 cells. Immunopharmacology and Immunotoxicology 2000, 22:279-295.
7. Pae H.O., Oh G.S., Kim N.Y., Shin M.K., Lee H.S., Yun Y.G., et al. Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe. In Vitro & Molecular Toxicology 2001, 14:99-106.
8. Lyu S.Y., Park W.B., Choi K.H., Kim W.H. Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells. Bioscience, Biotechnology, and Biochemistry 2001, 65:534-541.
9. Lyu S.Y., Park S.M., Choung B.Y., Park W.B. Comparative study of Korean (Viscum album var. coloratum) and European mistletoes (Viscum album). Archives of Pharmacal Research 2000, 23:592-598.
10. Lyu S.Y., Park W.B. Effects of Korean mistletoe lectin (Viscum album coloratum) on proliferation and cytokine expression in human peripheral blood mononuclear cells and T-lymphocytes. Archives of Pharmacal Research 2007, 10:1252-1264.
11. Fournier T., Handschuh K., Tsatsaris V., Guibourdenche J., Evain-Brion D. Role of nuclear receptors and their ligands in human trophoblast invasion. Journal of Reproductive Immunology 2008, 77:161-170.
12. Na K.H., Lee H.J., Choi J.H., Eun J.W., Nam S.W., Yoon T.K., et al. Dynamic alterations in integrin α4 expression by hypoxia are involved in trophoblast invasion during early implantation. Journal of Cellular Biochemistry 2012, 113:685-694.
13. Fitzgerald J.S., Germeyer A., Huppertz B., Jeschke U., Knöfler M., Moser G., et al. Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. American Journal of Reproductive Immunology 2010, 63:492-505.
14. Staun-Ram E., Goldman S., Shalev E. p53 mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion. Placenta 2009, 30:1029-1036.
15. Staun-Ram E., Goldman S., Gabarin D., Shalev E. Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reproductive Biology and Endocrinology 2004, 2:59.
16. Pollheimer J., Knöfler M. Signalling pathways regulating the invasive differentiation of human trophoblasts: a review. Placenta 2005, 26(Suppl. A):S21-S30.
17. Ilic D., Genbacev O., Jin F., Caceres E., Almeida E.A., Bellingard-Dubouchaud V., et al. Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. The American Journal of Pathology 2001, 159:93-108.
18. MacPhee D.J., Mostachfi H., Han R., Lye S.J., Post M., Caniggia I. Focal adhesion kinase is a key mediator of human trophoblast development. Laboratory Investigation 2001, 81:1469-1483.
19. Toker A., Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Research 2006, 66:3963-3966.
20. Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
21. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Reviews Cancer 2002, 2:489-501.
22. Neri L.M., Borgatti P., Capitani S., Martelli A.M. The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochimica et Biophysica Acta 2002, 1584:73-80.
23. Mitsiades C.S., Mitsiades N., Koutsilieris M. The Akt pathway: molecular targets for anti-cancer drug development. Current Cancer Drug targets 2004, 4:235-256.
24. Corvinus F.M., Fitzgerald J.S., Friedrich K., Markert U.R. Evidence for a correlation between trophoblast invasiveness and STAT3 activity. American Journal of Reproductive Immunology 2003, 50:316-321.
25. Classen-Linke I., Müller-Newen G., Heinrich P.C., Beier H.M., von Rango U. The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua. Molecular Human Reproduction 2004, 7:495-504.
26. Holtan S.G., Creedon D.J., Haluska P., Markovic S.N. Cancer and pregnancey. Parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents. Mayo Clinic Proceedings 2009, 84:985-1000.
27. van Mourik M.S., Macklon N.S., Heijnen C.J. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. Journal of Leukocyte Biology 2009, 85:4-19.
28. Fest S., Aldo P.B., Abrahams V.M., Visintin I., Alvero A., Chen R., et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. American Journal of Reproductive Immunology 2007, 57:55-66.
29. von Rango U. Fetal tolerance in human pregnancy-a crucial balance between acceptance and limitation of trophoblast invasion. Immunology Letters 2008, 115:21-32.
30. Lyu S.Y., Park W.B. Transport of mistletoe lectin by M cells in human intestinal follicle-associated epithelium (FAE) in vitro. Archives of Pharmacal Research 2008, 31:1613-1621.
31. Graham C.H., Hawley T.S., Hawley R.G., MacDougall J.R., Kerbel R.S., Khoo N., et al. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Experimental Cell Research 1993, 206:204-211.
32. Ferretti C., Bruni L., Dangles-Marie V., Pecking A.P., Bellet D. Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and mibratory capacities of trophoblasts. Human Reproduction Update 2007, 13:121-141.
33. Even-Ram S., Uziely B., Cohen P., Grisaru-Granovsky S., Maoz M., Ginzburg Y., et al. Thrombin receptor overexpression in malignant and physiological invasion process. Nature Medicine 1998, 4:909-914.
34. Genbacev O., Zhou Y., Ludlow J.W., Fisher S.J. Regulation of human placental development by oxygen tension. Science 1997, 277:1669-1672.
35. Mullen C.A. Review, analogies between trophoblastic and malignant cells. American Journal of Reproductive Immunology 1998, 39:41-49.
36. Redman C. Cytotrophoblasts, masters of disguise. Nature Medicine 1997, 3:610-611.
37. Strickland S., Richards W.G. Invasion of the trophoblasts. Cell 1992, 71:355-357.
38. Wen H.Y., Abbasi S., Kellems R.E., Xia Y. mTOR: a placental growth signaling sensor. Placenta 2005, 26(suppl. A):S63-S69.
39. Guo W., Giancotti F.G. Integrin signalling during tumour progression. Nature Reviews Molecular Cell Biology 2004, 5:816-826.
40. Schlaepfer D.D., Mitra S.K. Multiple connections link FAK to cell motility and invasion. Current Opinion in Genetics and Development 2004, 14:92-101.
41. Ilić D., Genbacev O., Jin F., Caceres E., Almeida E.A., Bellingard-Dubouchaud V., et al. Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. American Journal of Pathology 2001, 159:93-108.
42. Matalon S.T., Drucker L., Fishman A., Ornoy A., Lishner M. The role of heat shock protein 27 in extravillous trophoblast differentiation. Journal of Cellular Biochemistry 2008, 103:719-729.
43. Isaka K., Usuda S., Ito H., Sagawa Y., Nakamura H., Nishi H., et al. Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts. Placenta 2003, 24:53-64.
44. Bjorn S.F., Hastrup N., Larsen J.F., Lund L.R., Pyke C. Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester. Placenta 2000, 21:170-176.
45. Prast J., Saleh L., Husslein H., Sonderegger S., Helmer H., Knöfler M. Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling. Endocrinology 2008, 149:979-987.
46. Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry 1994, 269:5241-5248.
47. Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
48. Roos S., Jansson N., Palmberg I., Säljö K., Powell T.L., Jansson T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. The Journal of Physiology 2007, 582(pt. 1):449-459.
49. Abraham R.T., Eng C.H. Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opinion on Therapeutic Targets 2008, 12:209-222.
50. Knöfler M. Critical growth factors and signalling pathways controlling human trophoblast invasion. International Journal of Developmental Biology 2010, 54:269-280.
51. Qiu Q., Yang M., Tsang B.K., Gruslin A. EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways. Reproduction 2004, 128:355-363.
52. Morris V.A., Punjabi A.S., Lagunoff M. Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. Journal of Virology 2008, 82:8771-8779.
53. O'Brien C.A., Manolagas S.C. Isolation and characterization of the human gp130 promoter. Regulation by STATS. Journal of Biological Chemistry 1997, 272:15003-15010.