A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4

Neuroscience Letters

Volumn 543, Issue , 2013, Pages 157-162

  Bastos, Leandro F S ^a,b,c   Godin, Adriana M ^d   Zhang, Yingning ^b   Jarussophon, Suwatchai ^e,f   Ferreira, Bruno C S ^d   Machado, Renes R ^d   Maier, Steven F ^b   Konishi, Yasuo ^e   de Freitas, Rossimiriam P ^d   Fiebich, Bernd L ^c   Watkins, Linda R ^b   Coelho, Márcio M ^d   Moraes, Márcio F D ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UFMG   (Brazil)

^e NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^f NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

12S Hydroxy 1,12 pyrazolinominocycline; Chemically modified tetracycline; Neuropathic pain; PGE2; TLR2; TLR4

Indexed keywords

CALCIUM; DIVALENT CATION; HYDROXY 1,12 PYRAZOLINOMINOCYCLINE; MAGNESIUM ION; MINOCYCLINE; PROSTAGLANDIN E2; PYRAZOLINE DERIVATIVE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CHELATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; KIDNEY CELL; MICROGLIA; MOUSE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; SHAM PROCEDURE; SINGLE DRUG DOSE; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; DINOPROSTONE; FEMALE; HUMANS; HYPERALGESIA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; MINOCYCLINE; NEURALGIA; PHYSICAL STIMULATION; RATS; RATS, WISTAR; SCIATIC NERVE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOUCH;

EID: 84877126721     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.03.014     Document Type: Article

References (27)

1. Aronson A.L. Pharmacotherapeutics of the newer tetracyclines. J. Am. Vet. Med. Assoc. 1980, 176:1061-1068.
2. Bastos L.F.S., Angusti A., Vilaca M.C., Merlo L.A., Nascimento E.B., Rocha L.T.S., Godin A.M., Solano A.G.R., Jarussophon S., Nunan E.A., Konishi Y., Coelho M.M. A novel non-antibacterial, non-chelating hydroxypyrazoline derivative of minocycline inhibits nociception and oedema in mice. Br. J. Pharmacol. 2008, 155:714-721.
3. Bastos L.F.S., de Oliveira A.C.P., Schlachetzki J.C.M., Fiebich B.L. Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia. Immunopharm. Immunot. 2011, 33:576-580.
4. Bastos L.F.S., de Oliveira A.C.P., Watkins L.R., Moraes M.F.D., Coelho M.M. Tetracyclines and pain. N-S Arch. Pharmacol. 2012, 385:225-241.
5. Bastos L.F.S., Medeiros D.C., Vieira R.P., Watkins L.R., Coelho M.M., Moraes M.F.D. Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia. Neurosci. Lett. 2012, 510:20-23.
6. Bastos L.F.S., Merlo L.A., Rocha L.T.S., Coelho M.M. Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models. Eur. J. Pharmacol. 2007, 576:171-179.
7. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33:87-107.
8. Daood M.J., Hoyson M., Watchko J.F. Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. Pediatr. Res. 2012.
9. Decosterd I., Allchorne A., Woolf C.J. Differential analgesic sensitivity of two distinct neuropathic pain models. Anesth. Analg. 2004, 99:457-463.
10. Dray A. Neuropathic pain: emerging treatments. Br. J. Anaesth. 2008, 101:48-58.
11. Gaskill B.N., Rohr S.A., Pajor E.A., Lucas J.R., Garner J.P. Some like it hot: mouse temperature preferences in laboratory housing. Appl. Anim. Behav. Sci. 2009, 116:279-285.
12. Golub L.M., McNamara T.F., D'Angelo G., Greenwald R.A., Ramamurthy N.S. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J. Dent. Res. 1987, 66:1310-1314.
13. Goulden V., Glass D., Cunliffe W.J. Safety of long-term high-dose minocycline in the treatment of acne. Br. J. Dermatol. 1996, 134:693-695.
14. Hutchinson M.R., Zhang Y., Brown K., Coats B.D., Shridhar M., Sholar P.W., Patel S.J., Crysdale N.Y., Harrison J.A., Maier S.F., Rice K.C., Watkins L.R. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur. J. Neurosci. 2008, 28:20-29.
15. Inoue N., Ito S., Tajima K., Nogawa M., Takahashi Y., Sasagawa T., Nakamura A., Kyoi T. Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain. J. Pharmacol. Sci. 2009, 109:600-605.
16. Kawabata A. Prostaglandin E2 and pain - an update. Biol. Pharm. Bull. 2011, 34:1170-1173.
17. Kim D., Kim M.A., Cho I.H., Kim M.S., Lee S., Jo E.K., Choi S.Y., Park K., Kim J.S., Akira S., Na H.S., Oh S.B., Lee S.J. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J. Biol. Chem. 2007, 282:14975-14983.
18. Kim D., You B., Lim H., Lee S.J. Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. Mol. Pain 2011, 7:74.
19. Ledeboer A., Sloane E.M., Milligan E.D., Frank M.G., Mahony J.H., Maier S.F., Watkins L.R. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 2005, 115:71-83.
20. Lertvorachon J., Kim J.P., Soldatov D.V., Boyd J., Roman G., Cho S.J., Popek T., Jung Y.S., Lau P.C., Konishi Y. 1,12-Substituted tetracyclines as antioxidant agents. Bioorg. Med. Chem. 2005, 13:4627-4637.
21. Mei X.P., Xu H., Xie C., Ren J., Zhou Y., Zhang H., Xu L.X. Post-injury administration of minocycline: an effective treatment for nerve-injury induced neuropathic pain. Neurosci. Res. 2011, 70:305-312.
22. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
23. Nicotra L., Loram L.C., Watkins L.R., Hutchinson M.R. Toll-like receptors in chronic pain. Exp. Neurol. 2012, 234:316-329.
24. Padi S.S., Kulkarni S.K. Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. Pharmacol. Biochem. Behav. 2004, 79:349-358.
25. Raghavendra V., Tanga F., DeLeo J.A. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 2003, 306:624-630.
26. White J.P., Cantor C.R. Role of magnesium in the binding of tetracycline to Escherichia coli ribosomes. J. Mol. Biol. 1971, 58:397-400.
27. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.