A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Gerstein, Hilary ^a,b   Hullinger, Rikki ^b   Lindstrom, Mary J ^a   Burger, Corinna ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; JUVENILE ANIMAL; LEARNING DISORDER; MAZE TEST; MEMORY CONSOLIDATION; MENTAL TASK; MORRIS WATER MAZE; NONHUMAN; OBJECT LOCATION MEMORY TASK; RAT; SPATIAL MEMORY; TASK PERFORMANCE; VALIDATION STUDY;

AGING; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; GENETIC TECHNIQUES; HIPPOCAMPUS; MAZE LEARNING; MEMORY; RATS; REPRODUCIBILITY OF RESULTS; SPATIAL BEHAVIOR;

EID: 84877123929     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062360     Document Type: Article

References (41)

1. Gage FH, Dunnett SB, Björklund A, (1984) Spatial learning and motor deficits in aged rats. Neurobiol Aging 5: 43-48.
2. Gage FH, Björklund A, (1986) Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism. J Neurosci 6: 2837-2847.
3. deToledo-Morrell L, Geinisman Y, Morrell F, (1988) Age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders. Neurobiol Aging 9: 581-590.
4. Markowska AL, Stone WS, Ingram DK, Reynolds J, Gold PE, et al. (1989) Individual differences in aging: behavioral and neurobiological correlates. Neurobiol Aging 10: 31-43.
5. Gallagher M, Burwell R, Burchinal M, (1993) Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosci 107: 618-626.
6. Schulz D, Huston JP, Jezek K, Haas HL, Roth-Härer A, et al. (2002) Water maze performance, exploratory activity, inhibitory avoidance and hippocampal plasticity in aged superior and inferior learners. Eur J Neurosci 16: 2175-2185.
7. Burger C, López MC, Feller JA, Baker HV, Muzyczka N, et al. (2007) Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiol Learn Mem 87: 21-41 doi:10.1016/j.nlm.2006.05.003.
8. Burger C, López MC, Baker HV, Mandel RJ, Muzyczka N, (2008) Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus. Neurobiol Learn Mem 89: 379-396 doi:10.1016/j.nlm.2007.11.006.
9. Morris RGM, (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60.
10. Brody DL, Holtzman DM, (2006) Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp Neurol 197: 330-340 doi:10.1016/j.expneurol.2005.10.020.
11. Gallagher M, Burwell RD, (1989) Relationship of age-related decline across several behavioral domains. Neurobiol Aging 10: 691-708.
12. Lindner MD, (1997) Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze. Neurobiol Learn Mem 68: 203-220 doi:10.1006/nlme.1997.3782.
13. Colombo PJ, Gallagher M, (2002) Individual differences in spatial memory among aged rats are related to hippocampal PKCgamma immunoreactivity. Hippocampus 12: 285-289 doi:10.1002/hipo.10016.
14. Foster TC, Kumar A, (2007) Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats. Neurobiol Learn Mem 87: 522-535 doi:10.1016/j.nlm.2006.12.009.
15. Bizon JL, LaSarge CL, Montgomery KS, McDermott AN, Setlow B, et al. (2009) Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiol Aging 30: 646-655 doi:10.1016/j.neurobiolaging.2007.08.004.
16. Koh MT, Haberman RP, Foti S, Mccown TJ, Gallagher M, (2010) Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 35: 1016-1025 doi:10.1038/npp.2009.207.
17. Ennaceur A, Neave N, Aggleton JP, (1997) Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp Brain Res 113: 509-519.
18. Dix SL, Aggleton JP, (1999) Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behav Brain Res 99: 191-200.
19. Mumby DG, Gaskin S, Glenn MJ, Schramek TE, Lehmann H, (2002) Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn Mem 9: 49-57 doi:10.1101/lm.41302.
20. Rossato JI, Bevilaqua LRM, Myskiw JC, Medina JH, Izquierdo I, et al. (2007) On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory. Learn Mem 14: 36-46 doi:10.1101/lm.422607.
21. Balderas I, Rodriguez-Ortiz CJ, Salgado-Tonda P, Chavez-Hurtado J, McGaugh JL, et al. (2008) The consolidation of object and context recognition memory involve different regions of the temporal lobe. Learn Mem 15: 618-624 doi:10.1101/lm.1028008.
22. Murai T, Okuda S, Tanaka T, Ohta H, (2007) Characteristics of object location memory in mice: Behavioral and pharmacological studies. Physiol Behav 90: 116-124 doi:10.1016/j.physbeh.2006.09.013.
23. Stefanko DP, Barrett RM, Ly AR, Reolon GK, Wood MA, (2009) Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci USA 106: 9447-9452 doi:10.1073/pnas.0903964106.
24. Paban V, Chambon C, Jaffard M, Alescio-Lautier B, (2005) Behavioral effects of basal forebrain cholinergic lesions in young adult and aging rats. Behav Neurosci 119: 933-945 doi:10.1037/0735-7044.119.4.933.
25. Paban V, Jaffard M, Chambon C, Malafosse M, Alescio-Lautier B, (2005) Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention. Neuroscience 132: 13-32 doi:10.1016/j.neuroscience.2004.11.024.
26. Gerstein H, Lindstrom MJ, Burger C (2013) Gene delivery of Homer1c rescues spatial learning in a rodent model of cognitive aging. Neurobiol Aging, Mar 20. pii: S0197-4580(13)00068-7. doi: 10.1016/j.neurobiolaging.2013.02.006. [Epub ahead of print].
27. Luparini MR, Del Vecchio A, Barillari G, Magnani M, Prosdocimi M, (2000) Cognitive impairment in old rats: a comparison of object displacement, object recognition and water maze. Aging (Milano) 12: 264-273.
28. Markowska AL, Ingram DK, Barnes CA, Spangler EL, Lemken VJ, et al. (1990) Acetyl-1-carnitine. 1: Effects on mortality, pathology and sensory-motor performance in aging rats. Neurobiol Aging 11: 491-498.
29. Diniz DG, Foro CAR, Rego CMD, Gloria DA, de Oliveira FRR, et al. (2010) Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes. Eur J Neurosci 32: 509-519 doi:10.1111/j.1460-9568.2010.07296.x.
30. D'Hooge R, De Deyn PP, (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36: 60-90.
31. Robitsek RJ, Fortin NJ, Koh MT, Gallagher M, Eichenbaum H, (2008) Cognitive aging: a common decline of episodic recollection and spatial memory in rats. Journal of Neuroscience 28: 8945-8954 doi:10.1523/JNEUROSCI.1893-08.2008.
32. Gulinello M, Gertner M, Mendoza G, Schoenfeld BP, Oddo S, et al. (2009) Validation of a 2-day water maze protocol in mice. Behav Brain Res 196: 220-227 doi:10.1016/j.bbr.2008.09.002.
33. Day LB, Weisand M, Sutherland RJ, Schallert T, (1999) The hippocampus is not necessary for a place response but may be necessary for pliancy. Behav Neurosci 113: 914-924.
34. Martínez-Serrano A, Fischer W, Söderström S, Ebendal T, Björklund A, (1996) Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain. Proc Natl Acad Sci USA 93: 6355-6360.
35. Wu K, Li S, Bodhinathan K, Meyers C, Chen W, et al. (2012) Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology. Neurobiol Learn Mem 97: 69-80 doi:10.1016/j.nlm.2011.09.006.
36. Dellu F, Mayo W, Vallee M, Le Moal M, Simon H, (1997) Facilitation of cognitive performance in aged rats by past experience depends on the type of information processing involved: a combined cross-sectional and longitudinal study. Neurobiol Learn Mem 67: 121-128.
37. Doyère V, Gisquet-Verrier P, de Marsanich B, Ammassari-Teule M, (2000) Age-related modifications of contextual information processing in rats: role of emotional reactivity, arousal and testing procedure. Behav Brain Res 114: 153-165.
38. Gallagher M, Colantuoni C, Eichenbaum H, Haberman RP, Rapp PR, et al. (2006) Individual differences in neurocognitive aging of the medial temporal lobe. AGE 28: 221-233 doi:10.1007/s11357-006-9017-5.
39. Matzel LD, Han YR, Grossman H, Karnik MS, Patel D, et al. (2003) Individual differences in the expression of a "general" learning ability in mice. Journal of Neuroscience 23: 6423-6433.
40. Matzel LD, Grossman H, Light K, Townsend D, Kolata S, (2008) Age-related declines in general cognitive abilities of Balb/C mice are associated with disparities in working memory, body weight, and general activity. Learn Mem 15: 733-746 doi:10.1101/lm.954808.
41. Burger C (2010) Region-Specific Genetic Alterations in the Aging Hippocampus: Implications For Cognitive Aging. Front. Ag. Neurosci. 2, 1-12.