Functional analysis of the 5' untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum

Acta Tropica

Volumn 127, Issue 1, 2013, Pages 69-74

  Hasenkamp, Sandra ^a   Russell, Karen ^a   Ullah, Imran ^a   Horrocks, Paul ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Gene regulation; Luciferase; Malaria; PFD0660w; Transcription; Translation

Indexed keywords

ENZYME; LUCIFERASE; PHOSPHOGLUTAMASE 2; UNCLASSIFIED DRUG;

FUNCTIONAL RESPONSE; GENE EXPRESSION; GENETIC ANALYSIS; MALARIA; PARASITE; PATHOGEN;

5' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HOUSEKEEPING GENE; LUCIFERASE GENE; NONHUMAN; PFD0660W GENE; PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION; REPORTER GENE; RNA TRANSLATION;

5' UNTRANSLATED REGIONS; ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; PHOSPHOGLYCERATE MUTASE; PLASMODIUM FALCIPARUM; RNA, MESSENGER; RNA, PROTOZOAN;

EUKARYOTA; PLASMODIUM FALCIPARUM;

EID: 84877123218     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2013.03.007     Document Type: Article

References (35)

1. Amulic B., Salanti A., Lavstsen T., Nielsen M.A., Deitsch K.W. An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria. PLoS Pathog. 2009, 5:e1000256.
2. Bozdech Z., Llinas M., Pulliam B.L., Wong E.D., Zhu J., DeRisi J.L. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 2003, 1:e5.
3. Braks J.A.M., Mair G.R., Franke-Fayard B., Janse C.J., Waters A.P. A conserved U-rich RNA region implicated in regulation of translation in Plasmodium female gametocytes. Nucleic Acids Res. 2008, 36:1176-1186.
4. Brancucci N.M., Witmer K., Schmid C.D., Flueck C., Voss T.S. Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell. Microbiol. 2012, 14:1836-1848.
5. Campbell T.L., De Silva E.K., Olszewski K.L., Elemento O., Llinas M. Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog. 2010, 6:e1001165.
6. Cann H., Brown S.V., Oguariri R.M., Golightly L.M. 3' UTR signals necessary for expression of the Plasmodium gallinaceum ookinete protein, Pgs28, share similarities with those of yeast and plants. Mol. Biochem. Parasitol. 2004, 137:239-245.
7. Chookajorn T., Dzikowski R., Frank M., Li F., Jiwani A.Z., Hartl D.L., Deitsch K.W. Epigenetic memory at malaria virulence genes. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:899-902.
8. Cui L., Miao J. Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum. Eukaryotic Cell 2010, 9:1138-1149.
9. Deitsch K., Duraisingh M., Dzikowski R., Gunasekera A., Khan S., Le Roch K., Llinas M., Mair G., McGovern V., Roos D., Shock J., Sims J., Wiegand R., Winzeler E. Mechanisms of gene regulation in Plasmodium. Am. J. Trop. Med. Hyg. 2007, 77:201-208.
10. Golightly L.M., Mbacham W., Daily J., Wirth D.F. 3' UTR elements enhance expression of Pgs28, an ookinete protein of Plasmodium gallinaceum. Mol. Biochem. Parasitol. 2000, 105:61-70.
11. Gopalakrishnan A.M., Nyindodo L.A., Ross Fergus M., Lopez-Estrano C. Plasmodium falciparum: preinitiation complex occupancy of active and inactive promoters during erythrocytic stage. Exp. Parasitol. 2009, 121:46-54.
12. Hasenkamp S., Wong E.H., Horrocks P. An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum. Malar. J. 2012, 11:42.
13. Horrocks P., Dechering K., Lanzer M. Control of gene expression in Plasmodium falciparum. Mol. Biochem. Parasitol. 1998, 95:171-181.
14. Horrocks P., Kilbey B.J. Physical and functional mapping of the transcriptional start sites of Plasmodium falciparum proliferating cell nuclear antigen. Mol. Biochem. Parasitol. 1996, 82:207-215.
15. Horrocks P., Lanzer M. Differences in nucleosome organization over episomally located plasmids coincides with aberrant promoter activity in P. falciparum. Parasitol. Int. 1999, 48:55-61.
16. Horrocks P., Wong E., Russell K., Emes R.D. Control of gene expression in Plasmodium falciparum - ten years on. Mol. Biochem. Parasitol. 2009, 164:9-25.
17. Hughes K.R., Philip N., Starnes G.L., Taylor S., Waters A.P. From cradle to grave: RNA biology in malaria parasites. RNA 2010, 1:287-303.
18. Kozak M. Regulation of translation via mRNA structure in prokaryotes and eukaryotes. Gene 2005, 361:13-37.
19. Kyes S., Pinches R., Newbold C. A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum. Mol. Biochem. Parasitol. 2000, 105:311-315.
20. Lambros C., Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 1979, 65:418-420.
21. Lanzer M., de Bruin D., Ravetch J.V. Transcription mapping of a 100kb locus of Plasmodium falciparum identifies an intergenic region in which transcription terminates and reinitiates. EMBO J. 1992, 11:1949-1955.
22. Le Roch K.G., Johnson J.R., Florens L., Zhou Y., Santrosyan A., Grainger M., Yan S.F., Williamson K.C., Holder A.A., Carucci D.J., Yates J.R., Winzeler E.A. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res. 2004, 14:2308-2318.
23. Le Roch K.G., Zhou Y.Y., Blair P.L., Grainger M., Moch J.K., Haynes J.D., De la Vega P., Holder A.A., Batalov S., Carucci D.J., Winzeler E.A. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 2003, 301:1503-1508.
24. Liu Z., Miao J., Cui L. Gametocytogenesis in malaria parasite: commitment, development and regulation. Future Microbiol. 2011, 6:1351-1369.
25. Llinas M., Bozdech Z., Wong E.D., Adai A.T., DeRisi J.L. Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains. Nucleic Acids Res. 2006, 34:1166-1173.
26. Llinas M., Deitsch K.W., Voss T.S. Plasmodium gene regulation: far more to factor in. Trends Parasitol. 2008, 24:551-556.
27. Militello K.T., Dodge M., Bethke L., Wirth D.F. Identification of regulatory elements in the Plasmodium falciparum genome. Mol. Biochem. Parasitol. 2004, 134:75-88.
28. Nkrumah L.J., Muhle R.A., Moura P.A., Ghosh P., Hatfull G.F., Jacobs W.R., Fidock D.A. Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase. Nat. Methods 2006, 3:615-621.
29. Otto T.D., Wilinski D., Assefa S., Keane T.M., Sarry L.R., Bohme U., Lemieux J., Barrell B., Pain A., Berriman M., Newbold C., Llinas M. New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. Mol. Microbiol. 2010, 76:12-24.
30. Porter M.E. Positive and negative effects of deletions and mutations within the 5' flanking sequences of Plasmodium falciparum DNA polymerase delta. Mol. Biochem. Parasitol. 2002, 122:9-19.
31. Ruvolo V., Altszuler R., Levitt A. The transcript encoding the circumsporozoite antigen of Plasmodium berghei utilizes heterogeneous polyadenylation sites. Mol. Biochem. Parasitol. 1993, 57:137-150.
32. Scherf A., Lopez-Rubio J.J., Riviere L. Antigenic variation in Plasmodium falciparum. Ann. Rev. Microbiol. 2008, 62:445-470.
33. Shock J.L., Fischer K.F., DeRisi J.L. Whole-genome analysis of mRNA decay in Plasmodium falciparum reveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle. Genome Biol. 2007, 8:R314.
34. Sims J.S., Militello K.T., Sims P.A., Patel V.P., Kasper J.M., Wirth D.F. Stage-specific regulation of transcriptional activity in Plasmodium falciparum during the intraerythrocytic developmental cycle. Am. J. Trop. Med. Hyg. 2007, 77:290.
35. Wong E.H., Hasenkamp S., Horrocks P. Analysis of the molecular mechanisms governing the stage-specific expression of a prototypical housekeeping gene during intraerythrocytic development of P. falciparum. J. Mol. Biol. 2011, 408:205-221.