The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics

Cell Cycle

Volumn 12, Issue 9, 2013, Pages 1450-1456

  Strizzi, Luigi ^a   Margaryan, Naira V ^a   Gilgur, Alina ^a   Hardy, Katharine M ^a   Normanno, Nicola ^b   Salomon, David S ^c   Hendrix, Mary J C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aggressiveness; Cripto 1; Melanoma; Recurrence; Target; Tumorigenicity

Indexed keywords

CELL PROTEIN; CRIPTO 1 PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; SIGNAL PEPTIDE; TDGF1 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER STEM CELL; CELL LEVEL; CELL PROLIFERATION; CELL SUBPOPULATION; CELL SURFACE; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA CELL; MOUSE; NONHUMAN; PROGENY; PROTEIN EXPRESSION; TUMOR XENOGRAFT; ANIMAL; CARCINOGENESIS; CELL SEPARATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MELANOMA; METABOLISM; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOMA; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84877123131     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.24601     Document Type: Article

References (25)

1. Hendrix MJ, Seftor EA, Hess AR, Seftor RE. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 2003; 3:411-21; PMID:12778131; http://dx.doi.org/10.1038/nrc1092
2. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005; 65:9328-37; PMID:16230395; http://dx.doi.org/10.1158/0008-5472.CAN-05-1343
3. Assou S, Le Carrour T, Tondeur S, Ström S, Gabelle A, Marty S, et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a webbased expression atlas. Stem Cells 2007; 25:961-73; PMID:17204602; http://dx.doi.org/10.1634/stemcells.2006-0352
4. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006; 38:431-40; PMID:16518401; http://dx.doi.org/10.1038/ ng1760
5. Shen MM. Nodal signaling: developmental roles and regulation. Development 2007; 134:1023-34; PMID:17287255; http://dx.doi.org/10.1242/dev.000166
6. Strizzi L, Bianco C, Normanno N, Salomon D. Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis. Oncogene 2005; 24:5731-41; PMID:16123806; http://dx.doi.org/10.1038/sj.onc.1208918
7. De Luca A, Lamura L, Strizzi L, Roma C, D'Antonio A, Margaryan N, et al. Expression and functional role of CRIPTO-1 in cutaneous melanoma. Br J Cancer 2011; 105:1030-8; PMID:21863025; http://dx.doi.org/10.1038/bjc.2011.324
8. Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, et al. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 2006; 12:925-32; PMID:16892036; http://dx.doi.org/10.1038/nm1448
9. Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, et al. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA 2008; 105:4329-34; PMID:18334633; http://dx.doi.org/10.1073/pnas.0800467105
10. Bianco C, Rangel MC, Castro NP, Nagaoka T, Rollman K, Gonzales M, et al. Role of Cripto-1 in stem cell maintenance and malignant progression. Am J Pathol 2010; 177:532-40; PMID:20616345; http://dx.doi.org/10.2353/ajpath.2010.100102
11. Strizzi L, Abbott DE, Salomon DS, Hendrix MJ. Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma. Cell Cycle 2008; 7:1931-5; PMID:18604175; http://dx.doi.org/10.4161/cc.7.13.6236
12. Watanabe K, Meyer MJ, Strizzi L, Lee JM, Gonzales M, Bianco C, et al. Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells. Stem Cells 2010; 28:1303-14; PMID:20549704; http://dx.doi.org/10.1002/stem.463
13. Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010; 141:583-94; PMID:20478252; http://dx.doi.org/10.1016/j.cell.2010.04.020
14. Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, et al. MDR1 expression identifies human melanoma stem cells. Biochem Biophys Res Commun 2008; 368:930-6; PMID:18279661; http://dx.doi.org/10.1016/j.bbrc.2008. 02.022
15. Watanabe K, Nagaoka T, Lee JM, Bianco C, Gonzales M, Castro NP, et al. Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol 2009; 187:343-53; PMID:19948478; http://dx.doi.org/10.1083/jcb. 200905105
16. Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, et al. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol- phospholipase D and enhancement of endothelial cell migration. J Biol Chem 2007; 282:31643-55; PMID:17720976; http://dx.doi.org/10.1074/jbc.M702713200
17. Hardy KM, Kirschmann DA, Seftor EA, Margaryan NV, Postovit LM, Strizzi L, et al. Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res 2010; 70:10340-50; PMID:21159651; http://dx.doi.org/10.1158/0008-5472.CAN-10-0705
18. Liguori GL, Borges AC, D'Andrea D, Liguoro A, Gonçalves L, Salgueiro AM, et al. Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol 2008; 315:280-9; PMID:18241853; http://dx.doi.org/10.1016/j.ydbio.2007.12.027
19. Meyn MA 3rd, Schreiner SJ, Dumitrescu TP, Nau GJ, Smithgall TE. SRC family kinase activity is required for murine embryonic stem cell growth and differentiation. Mol Pharmacol 2005; 68:1320-30; PMID:15985613; http://dx.doi.org/10.1124/mol.104.010231
20. Scharenberg CW, Harkey MA, Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002; 99:507-12; PMID:11781231; http://dx.doi.org/10.1182/blood.V99.2.507
21. Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res 2005; 65:4320-33; PMID:15899824; http://dx.doi.org/10. 1158/0008-5472.CAN-04-3327
22. Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, Johnson TM, et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010; 18:510-23; PMID:21075313; http://dx.doi.org/10.1016/j.ccr.2010.10.012
23. Mancino M, Esposito C, Watanabe K, Nagaoka T, Gonzales M, Bianco C, et al. Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. Cancer Res 2009; 69:1717-21; PMID:19223540; http://dx.doi.org/10.1158/0008-5472.CAN-08-2985
24. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005; 65:9328-37; PMID:16230395; http://dx.doi.org/10.1158/0008-5472.CAN-05-1343
25. Meyer MJ, Fleming JM, Lin AF, Hussnain SA, Ginsburg E, Vonderhaar BK. CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptornegative breast cancer. Cancer Res 2010; 70:4624-33; PMID:20484027; http://dx.doi.org/10.1158/0008-5472.CAN-09-3619