Prognostic significance of BMP7 as an oncogene in hepatocellular carcinoma

Tumor Biology

Volumn 34, Issue 2, 2013, Pages 669-674

  Li, Wei ^a   Cai, Hong Xin ^b   Ge, Xu Ming ^a   Li, Kai ^a   Xu, Wei Dong ^a   Shi, Wei Hong ^b  

^a First Peoples' Hospital of LianYungang   (China)

^b Yancheng Health Vocational and Technical College   (China)

Author keywords

Biomarker; BMP7; Hepatocellular carcinoma; Prognosis

Indexed keywords

ALPHA FETOPROTEIN; MESSENGER RNA; OSTEOGENIC PROTEIN 1; BMP7 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BMP7 GENE; CANCER STAGING; CANCER SURGERY; CANCER TISSUE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LIVER CELL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; ONCOGENE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR VOLUME; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; FOLLOW UP; GENETICS; LIVER; LIVER TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE;

ADULT; AGED; BONE MORPHOGENETIC PROTEIN 7; CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

MLCS; MLOWN;

EID: 84877108518     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-012-0594-x     Document Type: Article

References (26)

1. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, TaylorRobinson SD. Hepatocellular carcinoma:current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol. 2009;3:353-67. doi: 10.1586/egh.09.35.
2. Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int. 2008;7:237-57.
3. Koorey D. Hepatocellular carcinoma: prevention, detection and treatment in the real world. Intern Med J. 2007;37:513-5. doi: 10.1111/j.1445-5994.2007. 01439.x.
4. Pleguezuelo M, Marelli L, Misseri M, Germani G, Calvaruso V, Xiruochakis E, Pinelopi M, Burroughs AK. TACE versus TAE as therapy for hepatocellular carcinoma. Expert Rev Anticancer Ther. 2008;8:1623-41. doi: 10.1586/14737140.8. 10.1623.
5. Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med. 2005;11:512-8.
6. Milan M. Sculpting a fly leg: BMP boundaries and cell death. Nat Cell Biol. 2007;9:17-8. doi: 10.1038/ncb0107-17.
7. Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science. 2002;296:1646-7. doi: 10.1126/science.1071809.
8. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005;19:2783-810. doi: 10.1101/gad.1350705.
9. Buijs JT, Rentsch CA, van der Horst G, van Overveld PG, Wetterwald A, Schwaninger R, Henriquez NV, Ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RC, Vukicevic S, Cecchini MG, Löwik CW, van der Pluijm G. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am J Pathol. 2007;171:1047-57. doi: 10.2353/ajpath.2007.070168.
10. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-tomesenchymal transition contributes to cardiac fibrosis. Nature. 2007;13:952-61. doi: 10.1038/nm1613.
11. Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjärvi T, Kallioniemi A. Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 2006;45:411-9. doi: 10.1002/gcc.20307.
12. Miyazaki H, Watabe T, Kitamura T, Miyazono K. BMP signals inhibit proliferation and in vivo tumor growth of androgeninsensitive prostate carcinoma cells. Oncogene. 2004;23:9326-35. doi: 10.1038/sj.onc.1208127.
13. Beck SE, Jung BH, Del Rosario E, Gomez J, Carethers JM. BMP induced growth suppression in colon cancer cells is mediated by p. 21(WAF1) stabilization and modulated by RAS/ERK. Cell Signal. 2007;19:1465-72. doi: 10.1016/j.cellsig.2007.01.017.
14. Motoyama K, Tanaka F, Kosaka Y, Mimori K, Uetake H, Inoue H, Sugihara K, Mori M. Clinical significance of BMP7 in human colorectal cancer. Ann Surg Oncol. 2008;15:1530-36. doi: 10.1245/s10434-007-9746-4.
15. Huang J, Zhu H, Wang X, Tang Q, Huang H, Wu K, Zhu J, Feng Z, Shi G. The patterns and expression of KDR in normal tissues of human internal organs. J Mol Histol. 2011;42:597-603. doi: 10.1007/s10735-011-9355-1.
16. Fang W, Li X, Jiang Q, Liu Z, Yang H, Wang S, Xie S, Liu Q, Liu T, Huang J, Xie W, Li Z, Zhao Y, Wang E, Marincola FM, Yao K. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med. 2008;6:32. doi: 10.1186/1479-5876-6-32.
17. Tu L, Liu Z, He X, He Y, Yang H, Jiang Q, Xie S, Xiao G, Li X, Yao K, Fang W. Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. Mol Cancer. 2010;9:78. doi: 10.1186/1476-4598-9-78.
18. Liu Z, Li L, Yang Z, Luo W, Li X, Yang H, Yao K, Wu B, Fang W. Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma. BMC Cancer. 2010;10:270. doi: 10.1186/1471-2407-10-270.
19. Zhu X-D, Zhang J-B, Zhuang P-Y, Zhu H-G, Zhang W, Xiong Y-Q, Wei-Zhong Wu L, Wang Z-YT, Sun H-C. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol. 2008;26:2707-16. doi: 10.1200/JCO.2007.15.6521.
20. Kelly K, Crowley J, Bunn Jr PA, Presant CA, Grevstad PK, Moinpour CM, Ramsey SD, Wozniak AJ, Weiss GR, Moore DF, Israel VK, Livingston RB, Gandara DR. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol. 2001;19:3210-8.
21. Hennessy BT, Hanrahan EO, Daly PA. Non-Hodgkin lymphoma: an update. Lancet Oncol. 2004;5:341-53.
22. Peng SY, Lai PL, Chu JS, Lee PH, Tsung PT, Chen DS, Hsu HC. Expression and hypomethylation of alpha-fetoprotein gene in unicentric and multicentric human hepatocellular carcinomas. Hepatology. 1993;17:35-41.
23. Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. β-catenin mutations are associated with a subset of low stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol. 2000;157:763-70.
24. Tuck AB, O'Malley FP, Singhal H, Harris JF, Tonkin KS, Kerkvliet N, Saad Z, Doig GS, Chambers AF. Osteopontin expression in a group of lymph node negative breast cancer patients. Int J Cancer. 1998;79:502-8. doi: 10.1002/(SICI)1097-0215(19981023.
25. Ue T, Yokozaki H, Kitadai Y, Yamamoto S, Yasui W, Ishikawa T, Tahara E. Co-expression of osteopontin and CD44v9 in gastric cancer. Int J Cancer. 1998;79:127-32. doi: 10.1002/(SICI)1097-0215(19980417.
26. Hwang YH, Choi JY, Kim S, Chung ES, Kim T, Koh SS, Lee B, Bae SH, Kim J, Park YM. Over-expression of c-raf-1proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatol Res. 2004;29:113-21.