Metabolism, metabolome, and metabolomics in intensive care: Is it time to move beyond monitoring of glucose and lactate?

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 9, 2013, Pages 906-907

  Kiehntopf, Michael ^a   Nin, Nicolas ^b,c   Bauer, Michael ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b HOSPITAL UNIVERSITARIO DE TORREJÓN   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOACETIC ACID; ACYLCARNITINE; ALANINE; ARACHIDONIC ACID; BILE ACID; BIOLOGICAL MARKER; CHOLESTEROL; CREATINE; GLUCOSE; INOSITOL; LACTIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PNEUMOLYSIN; PROCALCITONIN;

CRITICAL ILLNESS; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE SEVERITY; EDITORIAL; HUMAN; IMMUNOMODULATION; INFECTION; INFLAMMATION; INTENSIVE CARE; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LIQUID CHROMATOGRAPHY; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MASS SPECTROMETRY; METABOLIC DISORDER; METABOLITE; METABOLOME; METABOLOMICS; MICROBIAL IDENTIFICATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PATIENT MONITORING; PHENOTYPE; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEPSIS;

FEMALE; HUMANS; MALE; METABOLOMICS; SHOCK, SEPTIC;

EID: 84877108154     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201303-0414ED     Document Type: Editorial

References (11)

1. Heidegger CP, Berger MM, Graf S, Zingg W., Darmon P, Costanza MC, Thibault R, Pichard C. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 2013; 381:385-393.
2. Khovidhunkit W. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004; 45:1169-1196.
3. Feingold KR, Moser A, Patzek S.M., Shigenaga JK, Grunfeld C. Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm. J Lipid Res 2009; 50:2055-2063.
4. Schmerler D, Neugebauer S, Ludewig K., Bremer-Streck S, Brunkhorst FM, Kiehntopf M. Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. J Lipid Res 2012; 53:1369-1375.
5. Weber M, Lambeck S, Ding N., Henken S, Kohl M, Deigner H.P., Enot DP, Igwe EI, Frappart L, Kiehntopf M, et al. Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 2012; 26:2424-2436.
6. Slupsky CM. NMR-based analysis of metabolites in urine provides rapid diagnosis and etiology of pneumonia. Biomarkers Med 2010; 4:195-197.
7. Slupsky CM, Rankin KN, Fu H, Chang D., Rowe BH, Charles PGP, McGeer A, Low D., Long R, Kunimoto D, et al. Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile. J Proteome Res 2009; 8:5550-5558.
8. Izquierdo-García JL, Nin N, Ruíz-Cabello J, Rojas Y, Paula M, López-Cuenca S, Morales L, Martínez-Caro L, Fernândez-Segoviano P, Esteban A, et al. A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med 2011; 37:2023-2032.
9. Mickiewicz B, Vogel HJ, Wong H.R., Winston BW Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med 2013; 187:967-976.
10. Kareva I, Hahnfeldt P. The emerging "hallmarks" of metabolic reprogramming and immune evasion: distinct or linked? Cancer Res (In press)
11. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013; 13:260-268.