Genetic characterization of tigecycline resistance in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 5, 2013, Pages 1011-1018

  Veleba, Mark ^a   De majumdar, Shyamasree ^a   Hornsey, Michael ^b   Woodford, Neil ^b,c   Schneiders, Thamarai ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Antibiotic resistance; Gram negative; OqxAB; RamA; RarA

Indexed keywords

TIGECYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CONTROLLED STUDY; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HUMANS; MEMBRANE TRANSPORT PROTEINS; MINOCYCLINE; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 84877102301     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks530     Document Type: Article

References (26)

1. Maraki S, Samonis G, Karageorgopoulos DE et al. In vitro antimicrobial susceptibility to isepamicin of 6,296 Enterobacteriaceae clinical isolates collected at a tertiary care university hospital in Greece. Antimicrob Agents Chemother 2012; 56: 3067-73.
2. Ye Y, Li JB, Ye DQ et al. Enterobacter bacteremia: clinical features, risk factors for multiresistance and mortality in a Chinese University Hospital. Infection 2006; 34: 252-7.
3. Manzur A, Tubau F, Pujol M et al. Nosocomial outbreak due to extended-spectrum-β-lactamase-producing Enterobacter cloacae in a cardiothoracic intensive care unit. J Clin Microbiol 2007; 45: 2365-9.
4. Mallea M, Chevalier J, Bornet C et al. Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes. Microbiology 1998; 144: 3003-9.
5. Lindberg F, Lindquist S, Normark S. Genetic basis of induction and overproduction of chromosomal class I β-lactamase in nonfastidious gram-negative bacilli. Rev Infect Dis 1988; 10: 782-5.
6. Lee EH, Nicolas MH, Kitzis MD et al. Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem. Antimicrob Agents Chemother 1991; 35: 1093-8.
7. Livermore DM. Has the era of untreatable infections arrived? J Antimicrob Chemother 2009; 64: 29-36.
8. Li J, Nation RL, Turnidge JD et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis 2006; 6: 589-601.
9. Moken MC, McMurry LM, Levy SB. Selection of multiple-antibioticresistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci. Antimicrob Agents Chemother 1997; 41: 2770-2.
10. Alekshun MN, Levy SB. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob Agents Chemother 1997; 41: 2067-75.
11. Ruzin A, Visalli MA, Keeney D et al. Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob Agents Chemother 2005; 49: 1017-22.
12. Rosenblum R, Khan E, Gonzalez G et al. Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae. Int J Antimicrob Agents 2011; 38: 39-45.
13. Schneiders T, Amyes SG, Levy SB. Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrob Agents Chemother 2003; 47: 2831-7.
14. Keeney D, Ruzin A, Bradford PA. RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. Microb Drug Resist 2007; 13: 1-6.
15. Hornsey M, Ellington MJ, Doumith M et al. Emergence of AcrABmediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment. Int J Antimicrob Agents 2010; 35: 478-81.
16. Pradel E, Pages JM. The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes. Antimicrob Agents Chemother 2002; 46: 2640-3.
17. Chollet R, Chevalier J, Bollet C et al. RamA is an alternate activator of the multidrug resistance cascade in Enterobacter aerogenes. Antimicrob Agents Chemother 2004; 48: 2518-23.
18. Veleba M, Higgins PG, Gonzalez G et al. Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae. Antimicrob Agents Chemother 2012; 56: 4450-8.
19. Veleba M, Schneiders T. Tigecycline resistance can occur independently of the ramA gene in Klebsiella pneumoniae. Antimicrob Agents Chemother 2012; 56: 4466-7.
20. Andrews JM for the BSAC Working Party on Susceptibility Testing. BSAC standardized disc susceptibility testing method (version 8). J Antimicrob Chemother 2009; 64: 454-89.
21. Findlay J, Schneiders T. The differential effect of mutations in RamR in mediating antibiotic susceptibility in Klebsiella pneumoniae. In: Abstracts of the Nineteenth European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, 2009. Abstract O44, p. 16. European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland.
22. Buchan DWA, Ward SM, Lobley AE et al. Protein annotation and modelling servers at University College London. Nucleic Acids Res 2010; 38: W563-8.
23. Hawser SP, Lob S, Hoban D et al. Susceptibility of global intra-abdominal Enterobacteriaceae isolates to tigecycline (TEST 2007-2010). J Infection 2012; 64: 620-2.
24. Woodford N, Hill RLR, Livermore DM. In vitro activity of tigecycline against carbapenem-susceptible and -resistant isolates of Klebsiella spp. and Enterobacter spp. J Antimicrob Chemother 2007; 59: 582-3.
25. Perez A, Poza M, Fernandez A et al. Involvement of the AcrAB-TolC efflux pump in the resistance, fitness, and virulence of Enterobacter cloacae. Antimicrob Agents Chemother 2012; 56: 2084-90.
26. Hentschke M, Wolters M, Sobottka I et al. ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline. Antimicrob Agents Chemother 2010; 54: 2720-3.