Tigecycline resistance can occur independently of the ramA gene in Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4466-4467

  Veleba, Mark ^a   Schneiders, Thamarai ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; NORFLOXACIN; OLAQUINDOX; TETRACYCLINE; TIGECYCLINE;

ACRAB GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM MUTANT; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; KLEBSIELLA PNEUMONIAE; MARA GENE; MULTIDRUG RESISTANCE; NONHUMAN; OQXAB GENE; PHENOTYPE; PRIORITY JOURNAL; RAMA GENE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; KLEBSIELLA PNEUMONIAE; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; UP-REGULATION;

EID: 84864387244     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06224-11     Document Type: Article

References (13)

1. Al-Qadheeb NS, Althawadi S, Alkhalaf A, Hosaini S, Alrajhi AA. 2010. Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient. Ann. Saudi Med. 30:404-407.
2. Anthony KB, et al. 2008. Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline. Clin. Infect. Dis. 46:567-570. (Pubitemid 351263497)
3. Arya SC, Agarwal N. 2010. Emergence of tigecycline resistance amongst multi-drug resistant gram negative isolates in a multi-disciplinary hospital. J. Infect. 61:358-359.
4. Hamilton-Miller JMT. 1999. New BSAC sensitivity testing guidelines. J. Antimicrob. Chemother. 44:850-851.
5. Hansen LH, Jensen LB, Sorensen HI, Sorensen SJ. 2007. Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria. J. Antimicrob. Chemother. 60:145-147. (Pubitemid 47073289)
6. Hornsey M, et al. 2010. Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment. Int. J. Antimicrob. Agents 35:478-481.
7. Koutsolioutsou A, Martins EA, White DG, Levy SB, Demple B. 2001. A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (serovar Typhimurium). Antimicrob. Agents Chemother. 45:38-43. (Pubitemid 32039090)
8. Merlin C, McAteer S, Masters M. 2002. Tools for characterization of Escherichia coli genes of unknown function. J. Bacteriol. 184:4573-4581. (Pubitemid 34832585)
9. Neonakis IK, Stylianou K, Daphnis E, Maraki S. 2011. First case of resistance to tigecycline by Klebsiella pneumoniae in a European University Hospital. Indian J. Med. Microbiol. 29:78-79.
10. Rosenblum R, Khan E, Gonzalez G, Hasan R, Schneiders T. 2011. Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae. Int. J. Antimicrob. Agents 38:39-45.
11. Ruzin A, Visalli MA, Keeney D, Bradford PA. 2005. Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 49:1017-1022. (Pubitemid 40327718)
12. Sørensen AH, Hansen LH, Johannesen E, Sorensen SJ. 2003. Conjugative plasmid conferring resistance to olaquindox. Antimicrob. Agents Chemother. 47:798-799. (Pubitemid 36163336)
13. Veleba M, Higgins PG, Gonzalez G, Seifert H, Schneiders T. 2012. Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 56:4450-4458.