Is "rescue" therapy ethical in randomized controlled trials?

Pediatric Critical Care Medicine

Volumn 10, Issue 4, 2009, Pages

  Holubkov, Richard ^a   Dean, J Michael ^a   Berger, John ^b   Anand, Kanwaljeet J S ^c   Carcillo, Joseph ^d   Meert, Kathleen ^e   Zimmerman, Jerry ^f   Newth, Christopher ^g   Harrison, Rick ^h   Willson, Douglas F ⁱ   Nicholson, Carol ^j  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c ARKANSAS CHILDREN S HOSPITAL   (United States)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^e CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^f SEATTLE CHILDREN S HOSPITAL   (United States)

^g CHILDREN S HOSPITAL LOS ANGELES   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF VIRGINIA   (United States)

^j EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

more..

Author keywords

Corticosterone; Critical care; Equipoise; Ethics; Placebos; Randomized clinical trials; Rescue therapy; Septic shock

Indexed keywords

HYDROCORTISONE; PLACEBO;

ARTICLE; CLINICAL TRIAL; CORTICOSTEROID THERAPY; DRUG EFFICACY; DRUG SAFETY; ETHICAL DECISION MAKING; FATALITY; HIGH RISK POPULATION; HUMAN; INTENSIVE CARE; LOADING DRUG DOSE; MEDICAL ETHICS; MORALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; SEPTIC SHOCK;

EID: 70349282255     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e318198bd13     Document Type: Article

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