Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation

Biochemical and Biophysical Research Communications

Volumn 434, Issue 2, 2013, Pages 376-381

  Yurugi, Hajime ^a   Tanida, Shuhei ^a   Akita, Kaoru ^a   Ishida, Akiko ^a   Toda, Munetoyo ^a   Nakada, Hiroshi ^a  

^a KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

ERK1 2 signaling; Prohibitin; Siglec 9; T lymphocytes

Indexed keywords

INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 3; PROHIBITIN; RAF PROTEIN; SIALIC ACID; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN 9; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; T CELL LEUKEMIA; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD3; CHO CELLS; CRICETINAE; HUMANS; JURKAT CELLS; LIGANDS; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTINS; TRANSFECTION;

EID: 84877082492     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.085     Document Type: Article

References (21)

1. Rabinovich G.A., Toscano M.A. Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat. Rev. Immunol. 2009, 9:338-352.
2. Cao H., Crocker P.R. Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation. Immunology 2011, 132:18-26.
3. Varki A., Angata T. Siglecs-the major subfamily of I-type lectins. Glycobiology 2006, 16:1R-27R.
4. Stamenkovic I., Seed B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 1990, 345:74-77.
5. Toscano M.A., Bianco G.A., Ilarregui J.M., Croci D.O., Correale J., Hernandez J.D., Zwirner N.W., Poirier F., Riley E.M., Baum L.G., Rabinovich G.A. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol. 2007, 8:825-834.
6. Lock K., Zhang J., Lu J., Lee S.H., Crocker P.R. Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells. Immunobiology 2004, 209:199-207.
7. Mishra S., Ande S.R., Nyomba B.L.G. The role of prohibitin in cell signaling. FEBS J. 2010, 277:3937-3946.
8. Yurugi H., Tanida S., Ishida A., Akita K., Toda M., Inoue M., Nakada H. Expression of prohibitins on the surface of activated T cells. Biochem. Biophys. Res. Commun. 2012, 420:275-280.
9. Ohta M., Ishida A., Toda M., Akita K., Inoue M., Yamashita K., Watanabe M., Murata T., Usui T., Nakada H. Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9. Biochem. Biophys. Res. Commun. 2010, 402:663-669.
10. Nuell M.J., Stewart D.A., Walker L., Friedman V., Wood C.M., Owens G.A., Smith J.R., Schneider E.L., Dell' Orco R., Lumpkin C.K. Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol. Cell. Biol. 1991, 11:1372-1381.
11. Angata T., Varki A. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. J. Biol. Chem. 2000, 275:22127-22135.
12. Carlin A.F., Chang Y.-C., Areschoug T., Lindahl G., Hurtado-Ziola N., King C.C., Varki A., Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J. Exp. Med. 2009, 206:1691-1699.
13. Patel N., Brinkman-Van der Linden E.C., Altmann S.W., Gish K., Balasubramanian S., Timans J.C., Peterson D., Bell M.P., Bazan J.F., Varki A., Kastelein R.A. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J. Biol. Chem. 1999, 274:22729-22738.
14. Aalto K., Autio A., Kiss E.A., Elima K., Nymalm Y., Veres T.Z., Marttila-Ichihara F., Elovaara H., Saanijoki T., Crocker P.R., Maksimow M., Bligt E., Salminen T.A., Salmi M., Roivainen A., Jalkanen S. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood 2011, 118:3725-3733.
15. Winter A., Kämäräinen O., Hofmann A. Molecular modeling of prohibitin domains. Proteins 2007, 68:353-362.
16. Owaki H., Varma R., Gillis B., Bruder J.T., Rapp U.R., Davis L.S., Geppert T.D. Raf-1 is required for T cell IL2 production. EMBO J. 1993, 12:4367-4373.
17. Whitehurst C.E., Geppert T.D. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J. Immunol. 1996, 156:1020-1029.
18. Rajalingam K., Wunder C., Brinkmann V., Churin Y., Hekman M., Sievers C., Rapp U.R., Rudel T. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat. Cell Biol. 2005, 7:837-843.
19. Li L., Goleva E., Hall C.F., Ou L.S., Leung D.Y.M. Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway. J. Allergy Clin. Immunol. 2004, 114:1059-1069.
20. Tsukamoto H., Irie A., Nishimura Y. B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor. J. Biol. Chem. 2004, 279:48457-48465.
21. Kirchhof M.G., Chau L.A., Lemke C.D., Vardhana S., Darlington P.J., Márquez M.E., Taylor R., Rizkalla K., Blanca I., Dustin M.L., Madrenas J. Modulation of T cell activation by stomatin-like protein 2. J. Immunol. 2008, 181:1927-1936.