메뉴 건너뛰기




Volumn 16, Issue 2, 2013, Pages 250-256

Denosumab densitometric changes assessed by quantitative computed tomography at the spine and hip in postmenopausal women with osteoporosis

(15)  McClung, Michael R a   Zanchetta, Jose R b   Høiseth, Arne c   Kendler, David L d   Yuen, Chui Kin e   Brown, Jacques P f   Stonkus, Sigitas g   Goemaere, Stefan h   Recknor, Chris i   Woodson, Grattan C j   Bolognese, Michael A k   Franek, Edward l,m   Brandi, Maria Luisa n   Wang, Andrea o   Libanati, Cesar o  


Author keywords

Bone density; Denosumab; Osteoporosis; Quantitative computed tomography

Indexed keywords

CALCIUM; DENOSUMAB; VITAMIN D;

EID: 84877072861     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2012.02.014     Document Type: Article
Times cited : (35)

References (28)
  • 1
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis prevention, diagnosis, and therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy Osteoporosis prevention, diagnosis, and therapy. JAMA 2001, 285:785-795.
    • (2001) JAMA , vol.285 , pp. 785-795
  • 2
    • 79952394479 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis: executive summary of recommendations
    • Watts N.B., Bilezikian J.P., Camacho P.M., et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis: executive summary of recommendations. Endocr Pract 2010, 16:1016-1019.
    • (2010) Endocr Pract , vol.16 , pp. 1016-1019
    • Watts, N.B.1    Bilezikian, J.P.2    Camacho, P.M.3
  • 3
    • 33646883037 scopus 로고    scopus 로고
    • Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone
    • Bousson V., Le Bras A., Roqueplan F., et al. Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 2006, 17:855-864.
    • (2006) Osteoporos Int , vol.17 , pp. 855-864
    • Bousson, V.1    Le Bras, A.2    Roqueplan, F.3
  • 4
    • 33144465965 scopus 로고    scopus 로고
    • Cortical and trabecular load sharing in the human vertebral body
    • Eswaran S.K., Gupta A., Adams M.F., Keaveny T.M. Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res 2006, 21:307-314.
    • (2006) J Bone Miner Res , vol.21 , pp. 307-314
    • Eswaran, S.K.1    Gupta, A.2    Adams, M.F.3    Keaveny, T.M.4
  • 5
    • 61849145249 scopus 로고    scopus 로고
    • Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength
    • Holzer G., von Skrbensky G., Holzer L.A., Pichl W. Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength. J Bone Miner Res 2009, 24:468-474.
    • (2009) J Bone Miner Res , vol.24 , pp. 468-474
    • Holzer, G.1    von Skrbensky, G.2    Holzer, L.A.3    Pichl, W.4
  • 6
    • 52949090528 scopus 로고    scopus 로고
    • Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans
    • Keaveny T.M., Hoffmann P.F., Singh M., et al. Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res 2008, 23:1974-1982.
    • (2008) J Bone Miner Res , vol.23 , pp. 1974-1982
    • Keaveny, T.M.1    Hoffmann, P.F.2    Singh, M.3
  • 7
    • 79951839091 scopus 로고    scopus 로고
    • The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?
    • Khosla S., Melton L.J., Riggs B.L. The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?. J Bone Miner Res 2011, 26:441-451.
    • (2011) J Bone Miner Res , vol.26 , pp. 441-451
    • Khosla, S.1    Melton, L.J.2    Riggs, B.L.3
  • 8
    • 77952111123 scopus 로고    scopus 로고
    • Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    • Zebaze R.M., Ghasem-Zadeh A., Bohte A., et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 2010, 375:1729-1736.
    • (2010) Lancet , vol.375 , pp. 1729-1736
    • Zebaze, R.M.1    Ghasem-Zadeh, A.2    Bohte, A.3
  • 9
    • 0022070404 scopus 로고
    • Quantitative computed tomography for spinal mineral assessment: current status
    • Genant H.K., Cann C.E., Ettinger B., et al. Quantitative computed tomography for spinal mineral assessment: current status. J Comput Assist Tomogr 1985, 9:602-604.
    • (1985) J Comput Assist Tomogr , vol.9 , pp. 602-604
    • Genant, H.K.1    Cann, C.E.2    Ettinger, B.3
  • 10
    • 9344263428 scopus 로고    scopus 로고
    • Noninvasive assessment of bone mineral and structure: state of the art
    • Genant H.K., Engelke K., Fuerst T., et al. Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 1996, 11:707-730.
    • (1996) J Bone Miner Res , vol.11 , pp. 707-730
    • Genant, H.K.1    Engelke, K.2    Fuerst, T.3
  • 11
    • 47849099623 scopus 로고    scopus 로고
    • Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    • Black D.M., Bouxsein M.L., Marshall L.M., et al. Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res 2008, 23:1326-1333.
    • (2008) J Bone Miner Res , vol.23 , pp. 1326-1333
    • Black, D.M.1    Bouxsein, M.L.2    Marshall, L.M.3
  • 12
    • 34248641980 scopus 로고    scopus 로고
    • An update on the assessment of osteoporosis using radiologic techniques
    • Damilakis J., Maris T.G., Karantanas A.H. An update on the assessment of osteoporosis using radiologic techniques. Eur Radiol 2007, 17:1591-1602.
    • (2007) Eur Radiol , vol.17 , pp. 1591-1602
    • Damilakis, J.1    Maris, T.G.2    Karantanas, A.H.3
  • 13
    • 42649115770 scopus 로고    scopus 로고
    • Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions
    • Engelke K., Adams J.E., Armbrecht G., et al. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions. J Clin Densitom 2008, 11:123-162.
    • (2008) J Clin Densitom , vol.11 , pp. 123-162
    • Engelke, K.1    Adams, J.E.2    Armbrecht, G.3
  • 14
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey D.L., Tan H.L., Lu J., et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 2000, 157:435-448.
    • (2000) Am J Pathol , vol.157 , pp. 435-448
    • Lacey, D.L.1    Tan, H.L.2    Lu, J.3
  • 15
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 16
    • 17744388339 scopus 로고    scopus 로고
    • Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    • Udagawa N., Takahashi N., Yasuda H., et al. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology 2000, 141:3478-3484.
    • (2000) Endocrinology , vol.141 , pp. 3478-3484
    • Udagawa, N.1    Takahashi, N.2    Yasuda, H.3
  • 17
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H., Shima N., Nakagawa N., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 1998, 95:3597-3602.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3
  • 18
    • 79952698455 scopus 로고    scopus 로고
    • Denosumab and bisphosphonates: different mechanisms of action and effects
    • Baron R., Ferrari S., Russell R.G. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 2011, 48:677-692.
    • (2011) Bone , vol.48 , pp. 677-692
    • Baron, R.1    Ferrari, S.2    Russell, R.G.3
  • 19
    • 3342982829 scopus 로고    scopus 로고
    • A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
    • Bekker P.J., Holloway D.L., Rasmussen A.S., et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004, 19:1059-1066.
    • (2004) J Bone Miner Res , vol.19 , pp. 1059-1066
    • Bekker, P.J.1    Holloway, D.L.2    Rasmussen, A.S.3
  • 20
    • 45149124792 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women
    • Bone H.G., Bolognese M.A., Yuen C.K., et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab 2008, 93:2149-2157.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2149-2157
    • Bone, H.G.1    Bolognese, M.A.2    Yuen, C.K.3
  • 21
    • 58149099647 scopus 로고    scopus 로고
    • Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial
    • Brown J.P., Prince R.L., Deal C., et al. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res 2009, 24:153-161.
    • (2009) J Bone Miner Res , vol.24 , pp. 153-161
    • Brown, J.P.1    Prince, R.L.2    Deal, C.3
  • 22
    • 69049083492 scopus 로고    scopus 로고
    • Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • Cummings S.R., San Martin J., McClung M.R., et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009, 361:756-765.
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 23
    • 38749105490 scopus 로고    scopus 로고
    • Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD
    • Lewiecki E.M., Miller P.D., McClung M.R., et al. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res 2007, 22:1832-1841.
    • (2007) J Bone Miner Res , vol.22 , pp. 1832-1841
    • Lewiecki, E.M.1    Miller, P.D.2    McClung, M.R.3
  • 24
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung M.R., Lewiecki E.M., Cohen S.B., et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006, 354:821-831.
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.R.1    Lewiecki, E.M.2    Cohen, S.B.3
  • 25
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial
    • Miller P.D., Bolognese M.A., Lewiecki E.M., et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone 2008, 43:222-229.
    • (2008) Bone , vol.43 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3
  • 26
    • 77955706112 scopus 로고    scopus 로고
    • Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density
    • Genant H.K., Engelke K., Hanley D.A., et al. Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density. Bone 2010, 47:131-139.
    • (2010) Bone , vol.47 , pp. 131-139
    • Genant, H.K.1    Engelke, K.2    Hanley, D.A.3
  • 27
    • 84863174809 scopus 로고    scopus 로고
    • Denosumab improves both femoral and vertebral strength in women with osteoporosis: results from the FREEDOM trial
    • Keaveny T., McClung M., Genant H., et al. Denosumab improves both femoral and vertebral strength in women with osteoporosis: results from the FREEDOM trial. J Bone Miner Res 2010, 25(S1):S31.
    • (2010) J Bone Miner Res , vol.25 S1
    • Keaveny, T.1    McClung, M.2    Genant, H.3
  • 28
    • 79955117784 scopus 로고    scopus 로고
    • Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk
    • Boonen S., Adachi J.D., Man Z., et al. Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk. J Clin Endocrin Metab 2011, 96:1727-1736.
    • (2011) J Clin Endocrin Metab , vol.96 , pp. 1727-1736
    • Boonen, S.1    Adachi, J.D.2    Man, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.