-
1
-
-
74049133361
-
The global burden of cancer: priorities for prevention
-
Thun MJ, DeLancey JO, (2010) Center MM, Jemal A, Ward EM (2010) The global burden of cancer: priorities for prevention. Carcinogenesis 31: 100-110.
-
(2010)
Carcinogenesis
, vol.31
, pp. 100-110
-
-
Thun, M.J.1
DeLancey, J.O.2
Center, M.M.3
Jemal, A.4
Ward, E.M.5
-
2
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
-
3
-
-
66449133323
-
A change of strategy in the war on cancer
-
Gatenby RA, (2009) A change of strategy in the war on cancer. Nature 459: 508-509.
-
(2009)
Nature
, vol.459
, pp. 508-509
-
-
Gatenby, R.A.1
-
4
-
-
11144242211
-
Timeline: Chemotherapy and the war on cancer
-
Chabner BA, Roberts TG Jr, (2005) Timeline: Chemotherapy and the war on cancer. Nat Rev Cancer 5: 65-72.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 65-72
-
-
Chabner, B.A.1
Roberts Jr., T.G.2
-
5
-
-
67649595826
-
Apoptosis and cancer: the genesis of a research field
-
Cotter TG, (2009) Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 9: 501-507.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 501-507
-
-
Cotter, T.G.1
-
6
-
-
27644575716
-
Drug resistance in cancer
-
Yague E, Raguz S, (2005) Drug resistance in cancer. Br J Cancer 93: 973-976.
-
(2005)
Br J Cancer
, vol.93
, pp. 973-976
-
-
Yague, E.1
Raguz, S.2
-
7
-
-
77955175216
-
Strategies in the design of nanoparticles for therapeutic applications
-
Petros RA, DeSimone JM, (2010) Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9: 615-627.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 615-627
-
-
Petros, R.A.1
DeSimone, J.M.2
-
8
-
-
84869500832
-
Challenges in design and characterization of ligand-targeted drug delivery systems
-
Muro S, (2012) Challenges in design and characterization of ligand-targeted drug delivery systems. J Control Release 164: 125-137.
-
(2012)
J Control Release
, vol.164
, pp. 125-137
-
-
Muro, S.1
-
9
-
-
84862698355
-
Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress
-
Lammers T, Kiessling F, Hennink WE, Storm G, (2012) Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release 161: 175-187.
-
(2012)
J Control Release
, vol.161
, pp. 175-187
-
-
Lammers, T.1
Kiessling, F.2
Hennink, W.E.3
Storm, G.4
-
11
-
-
83555165989
-
Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances
-
Kizek R, Adam V, Hrabeta J, Eckschlager T, Smutny S, et al. (2012) Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances. Pharmacol Ther 133: 26-39.
-
(2012)
Pharmacol Ther
, vol.133
, pp. 26-39
-
-
Kizek, R.1
Adam, V.2
Hrabeta, J.3
Eckschlager, T.4
Smutny, S.5
-
12
-
-
84860523994
-
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies
-
Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, et al. (2012) Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol 52: 1213-1225.
-
(2012)
J Mol Cell Cardiol
, vol.52
, pp. 1213-1225
-
-
Octavia, Y.1
Tocchetti, C.G.2
Gabrielson, K.L.3
Janssens, S.4
Crijns, H.J.5
-
13
-
-
2642566088
-
Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
-
Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L, (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185-229.
-
(2004)
Pharmacol Rev
, vol.56
, pp. 185-229
-
-
Minotti, G.1
Menna, P.2
Salvatorelli, E.3
Cairo, G.4
Gianni, L.5
-
14
-
-
84862526571
-
Current and proposed biomarkers of anthracycline cardiotoxicity in cancer: emerging opportunities in oxidative damage and autophagy
-
Dickey JS, Rao VA, (2012) Current and proposed biomarkers of anthracycline cardiotoxicity in cancer: emerging opportunities in oxidative damage and autophagy. Curr Mol Med 12: 763-771.
-
(2012)
Curr Mol Med
, vol.12
, pp. 763-771
-
-
Dickey, J.S.1
Rao, V.A.2
-
15
-
-
84858693977
-
Anthracycline cardiotoxicity
-
Menna P, Paz OG, Chello M, Covino E, Salvatorelli E, et al. (2012) Anthracycline cardiotoxicity. Expert Opin Drug Saf 11Suppl 1: S21-36.
-
(2012)
Expert Opin Drug Saf
, vol.11
-
-
Menna, P.1
Paz, O.G.2
Chello, M.3
Covino, E.4
Salvatorelli, E.5
-
16
-
-
79955844782
-
Genetic abnormalities in leukemia secondary to treatment in patients with Hodgkin's disease
-
Salas C, Perez-Vera P, Frias S, (2011) Genetic abnormalities in leukemia secondary to treatment in patients with Hodgkin's disease. Rev Invest Clin 63: 53-63.
-
(2011)
Rev Invest Clin
, vol.63
, pp. 53-63
-
-
Salas, C.1
Perez-Vera, P.2
Frias, S.3
-
17
-
-
84863549072
-
Pharmacophore, QSAR, and binding mode studies of substrates of human cytochrome P450 2D6 (CYP2D6) using molecular docking and virtual mutations and an application to chinese herbal medicine screening
-
Mo SL, Liu WF, Li CG, Zhou ZW, Luo HB, et al. (2012) Pharmacophore, QSAR, and binding mode studies of substrates of human cytochrome P450 2D6 (CYP2D6) using molecular docking and virtual mutations and an application to chinese herbal medicine screening. Curr Pharm Biotechnol 13: 1640-1704.
-
(2012)
Curr Pharm Biotechnol
, vol.13
, pp. 1640-1704
-
-
Mo, S.L.1
Liu, W.F.2
Li, C.G.3
Zhou, Z.W.4
Luo, H.B.5
-
18
-
-
84863246281
-
Ligand- and protein-based modeling studies of the inhibitors of human cytochrome P450 2D6 and a virtual screening for potential inhibitors from the Chinese herbal medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap)
-
Mo SL, Liu WF, Chen Y, Luo HB, Sun LB, et al. (2012) Ligand- and protein-based modeling studies of the inhibitors of human cytochrome P450 2D6 and a virtual screening for potential inhibitors from the Chinese herbal medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap). Comb Chem High Throughput Screen 15: 36-80.
-
(2012)
Comb Chem High Throughput Screen
, vol.15
, pp. 36-80
-
-
Mo, S.L.1
Liu, W.F.2
Chen, Y.3
Luo, H.B.4
Sun, L.B.5
-
19
-
-
67650287075
-
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
-
Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, et al. (2009) Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol 16: 698-703.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 698-703
-
-
Bishop, B.1
Aricescu, A.R.2
Harlos, K.3
O'Callaghan, C.A.4
Jones, E.Y.5
-
20
-
-
77958168199
-
Pharmacophore mapping, molecular docking and QSAR studies of structurally diverse compounds as CYP2B6 inhibitors
-
Roy PP, Roy K, (2010) Pharmacophore mapping, molecular docking and QSAR studies of structurally diverse compounds as CYP2B6 inhibitors. Mol Simul 36: 887-905.
-
(2010)
Mol Simul
, vol.36
, pp. 887-905
-
-
Roy, P.P.1
Roy, K.2
-
21
-
-
0041781898
-
Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm
-
Wu G, Robertson DH, Brooks CL 3rd, Vieth M, (2003) Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm. J Comput Chem 24: 1549-1562.
-
(2003)
J Comput Chem
, vol.24
, pp. 1549-1562
-
-
Wu, G.1
Robertson, D.H.2
Brooks 3rd, C.L.3
Vieth, M.4
-
22
-
-
77950366686
-
Identification of ROS using oxidized DCFDA and flow-cytometry
-
Eruslanov E, Kusmartsev S, (2010) Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 594: 57-72.
-
(2010)
Methods Mol Biol
, vol.594
, pp. 57-72
-
-
Eruslanov, E.1
Kusmartsev, S.2
-
23
-
-
0032820452
-
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
-
Wang H, Joseph JA, (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27: 612-616.
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 612-616
-
-
Wang, H.1
Joseph, J.A.2
-
24
-
-
73649194769
-
Improved method for the determination of blood glutathione
-
Beutler E, Duron O, Kelly BM, (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61: 882-888.
-
(1963)
J Lab Clin Med
, vol.61
, pp. 882-888
-
-
Beutler, E.1
Duron, O.2
Kelly, B.M.3
-
25
-
-
0000230094
-
Cooperative binding by aggregated mono-6-(alkylamino)-β-cyclodextrins
-
Petter RC, Salek JS, Sikorski CT, Kumaravel G, Lin FT, (1990) Cooperative binding by aggregated mono-6-(alkylamino)-β-cyclodextrins. J Am Chem Soc 112: 3860-3868.
-
(1990)
J Am Chem Soc
, vol.112
, pp. 3860-3868
-
-
Petter, R.C.1
Salek, J.S.2
Sikorski, C.T.3
Kumaravel, G.4
Lin, F.T.5
-
26
-
-
84862248102
-
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
-
Crider KS, Yang TP, Berry RJ, Bailey LB, (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr 3: 21-38.
-
(2012)
Adv Nutr
, vol.3
, pp. 21-38
-
-
Crider, K.S.1
Yang, T.P.2
Berry, R.J.3
Bailey, L.B.4
-
27
-
-
1942439040
-
Folate receptor endocytosis and trafficking
-
Sabharanjak S, Mayor S, (2004) Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 56: 1099-1109.
-
(2004)
Adv Drug Deliv Rev
, vol.56
, pp. 1099-1109
-
-
Sabharanjak, S.1
Mayor, S.2
-
28
-
-
27944455140
-
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
-
Hilgenbrink AR, Low PS, (2005) Folate receptor-mediated drug targeting: from therapeutics to diagnostics. J Pharm Sci 94: 2135-2146.
-
(2005)
J Pharm Sci
, vol.94
, pp. 2135-2146
-
-
Hilgenbrink, A.R.1
Low, P.S.2
-
29
-
-
41449098351
-
Targeted drug delivery via folate receptors
-
Zhao X, Li H, Lee RJ, (2008) Targeted drug delivery via folate receptors. Expert Opin Drug Deliv 5: 309-319.
-
(2008)
Expert Opin Drug Deliv
, vol.5
, pp. 309-319
-
-
Zhao, X.1
Li, H.2
Lee, R.J.3
-
30
-
-
0026752798
-
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
-
Weitman SD, Lark RH, Coney LR, Fort DW, Frasca V, et al. (1992) Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 52: 3396-3401.
-
(1992)
Cancer Res
, vol.52
, pp. 3396-3401
-
-
Weitman, S.D.1
Lark, R.H.2
Coney, L.R.3
Fort, D.W.4
Frasca, V.5
-
31
-
-
10444279209
-
Cyclodextrin-based pharmaceutics: past, present and future
-
Davis ME, Brewster ME, (2004) Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov 3: 1023-1035.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 1023-1035
-
-
Davis, M.E.1
Brewster, M.E.2
-
32
-
-
79954607103
-
Cyclodextrin-based inclusion complexation bridging supramolecular chemistry and macromolecular self-assembly
-
Chen G, Jiang M, (2011) Cyclodextrin-based inclusion complexation bridging supramolecular chemistry and macromolecular self-assembly. Chem Soc Rev 40: 2254-2266.
-
(2011)
Chem Soc Rev
, vol.40
, pp. 2254-2266
-
-
Chen, G.1
Jiang, M.2
-
33
-
-
75349083555
-
Host-guest complexation studied by fluorescence correlation spectroscopy: adamantane-cyclodextrin inclusion
-
Granadero D, Bordello J, Perez-Alvite MJ, Novo M, Al-Soufi W, (2010) Host-guest complexation studied by fluorescence correlation spectroscopy: adamantane-cyclodextrin inclusion. Int J Mol Sci 11: 173-188.
-
(2010)
Int J Mol Sci
, vol.11
, pp. 173-188
-
-
Granadero, D.1
Bordello, J.2
Perez-Alvite, M.J.3
Novo, M.4
Al-Soufi, W.5
-
34
-
-
80054920730
-
Possibilities to increase the effectiveness of doxorubicin in cancer cells killing
-
Hanusova V, Bousova I, Skalova L, (2011) Possibilities to increase the effectiveness of doxorubicin in cancer cells killing. Drug Metab Rev 43: 540-557.
-
(2011)
Drug Metab Rev
, vol.43
, pp. 540-557
-
-
Hanusova, V.1
Bousova, I.2
Skalova, L.3
-
35
-
-
84869507166
-
Finding the optimal balance: Challenges of improving conventional cancer chemotherapy using suitable combinations with nano-sized drug delivery systems
-
Kratz F, Warnecke A, (2012) Finding the optimal balance: Challenges of improving conventional cancer chemotherapy using suitable combinations with nano-sized drug delivery systems. J Control Release 164: 221-235.
-
(2012)
J Control Release
, vol.164
, pp. 221-235
-
-
Kratz, F.1
Warnecke, A.2
-
36
-
-
84877037226
-
Water-dispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic actions
-
Fan J, Fang G, Zeng F, Wang X, Wu S (2012) Water-dispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic actions. Small.
-
(2012)
Small
-
-
Fan, J.1
Fang, G.2
Zeng, F.3
Wang, X.4
Wu, S.5
-
37
-
-
84866334630
-
Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix
-
Hochdorffer K, Abu Ajaj K, Schafer-Obodozie C, Kratz F, (2012) Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix. J Med Chem 55: 7502-7515.
-
(2012)
J Med Chem
, vol.55
, pp. 7502-7515
-
-
Hochdorffer, K.1
Abu Ajaj, K.2
Schafer-Obodozie, C.3
Kratz, F.4
-
38
-
-
84861037988
-
Synthesis and antitumor efficacy of a β-glucuronidase-responsive albumin-binding prodrug of doxorubicin
-
Legigan T, Clarhaut J, Renoux B, Tranoy-Opalinski I, Monvoisin A, et al. (2012) Synthesis and antitumor efficacy of a β-glucuronidase-responsive albumin-binding prodrug of doxorubicin. J Med Chem 55: 4516-4520.
-
(2012)
J Med Chem
, vol.55
, pp. 4516-4520
-
-
Legigan, T.1
Clarhaut, J.2
Renoux, B.3
Tranoy-Opalinski, I.4
Monvoisin, A.5
|