메뉴 건너뛰기




Volumn 13, Issue 12, 2012, Pages 6357-6362

Prevalence and clinical significance of mammalian target of rapamycin phosphorylation (p-mtor) and vascular endothelial growth factor (VEGF) in clear cell carcinoma of the ovary

Author keywords

Immunohistochemistry; Ovarian clear cell carcinoma; p mTOR; VEGF

Indexed keywords

MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84877067313     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.12.6357     Document Type: Article
Times cited : (4)

References (28)
  • 1
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare DA, Wang HQ, Skele KL, et al (2004). AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene, 23, 5853-7.
    • (2004) Oncogene , vol.23 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3
  • 2
    • 0032143851 scopus 로고    scopus 로고
    • Clinical characteristics of clear cell carcinoma of the ovary
    • Behbakht K, Randall TC, Benjamin I, et al (1998). Clinical characteristics of clear cell carcinoma of the ovary. Gynecol Oncol, 70, 255-8.
    • (1998) Gynecol Oncol , vol.70 , pp. 255-258
    • Behbakht, K.1    Randall, T.C.2    Benjamin, I.3
  • 3
    • 80052588957 scopus 로고    scopus 로고
    • Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a gynecologic oncology group study
    • Behbakht K, Sill MW, Darcy KM, et al (2011). Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a gynecologic oncology group study. Gynecol Oncol, 123, 19-26.
    • (2011) Gynecol Oncol , vol.123 , pp. 19-26
    • Behbakht, K.1    Sill, M.W.2    Darcy, K.M.3
  • 4
    • 7944223834 scopus 로고    scopus 로고
    • Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
    • Chan S (2004).Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer, 91, 1420-4.
    • (2004) Br J Cancer , vol.91 , pp. 1420-1424
    • Chan, S.1
  • 6
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19, 6680-6.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 7
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S, Houghton PJ (2003). Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol, 3, 371-7.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 8
    • 36749068988 scopus 로고    scopus 로고
    • Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
    • Huynh H, Teo CC, Soo KC (2007). Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol Cancer Ther, 6, 2959-66.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2959-2966
    • Huynh, H.1    Teo, C.C.2    Soo, K.C.3
  • 9
    • 84869493683 scopus 로고    scopus 로고
    • Clinical trials and future potential of targeted therapy for ovarian cancer
    • Itamochi H, Kigawa J (2012). Clinical trials and future potential of targeted therapy for ovarian cancer. Int J Clin Oncol, 17, 430-40.
    • (2012) Int J Clin Oncol , vol.17 , pp. 430-440
    • Itamochi, H.1    Kigawa, J.2
  • 10
    • 27644447574 scopus 로고    scopus 로고
    • The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy
    • Janus A, Robak T, Smolewski P (2005). The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy. Cell Mol Biol Lett, 10, 479-98.
    • (2005) Cell Mol Biol Lett , vol.10 , pp. 479-498
    • Janus, A.1    Robak, T.2    Smolewski, P.3
  • 11
    • 67650874081 scopus 로고    scopus 로고
    • Cancer statistics, 2009. CA Cancer J Clin; published online. doi:10.3322/caac.20006. Available from
    • Jemal A, Siegel R, Ward E, et al (2009).Cancer statistics, 2009. CA Cancer J Clin; published online. doi:10.3322/caac.20006. Available from http://seer.cancer.gov/statfacts/html/ovary.html#ref09 and http://seer.cancer.gov/search?q=serous+ovary+2009.
    • (2009)
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 12
    • 69949109923 scopus 로고    scopus 로고
    • mTOR Is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary
    • Mabuchi S, Kawase C, Altomare DA, et al (2009). mTOR Is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res, 15, 5404-13.
    • (2009) Clin Cancer Res , vol.15 , pp. 5404-5413
    • Mabuchi, S.1    Kawase, C.2    Altomare, D.A.3
  • 14
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • Mita MM, Mita A, Rowinsky EK (2003). The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther, 2, 169-77.
    • (2003) Cancer Biol Ther , vol.2 , pp. 169-177
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 15
    • 57649231823 scopus 로고    scopus 로고
    • Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma
    • Miyazawa M, Yasuda M, Fujita M, et al (2009). Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. Pathol Int, 59, 19-27.
    • (2009) Pathol Int , vol.59 , pp. 19-27
    • Miyazawa, M.1    Yasuda, M.2    Fujita, M.3
  • 16
    • 75149146772 scopus 로고    scopus 로고
    • A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer
    • Nagaraja AK, Creighton CJ, Yu Z, et al (2010). A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol Endocrinol, 24, 447-63.
    • (2010) Mol Endocrinol , vol.24 , pp. 447-463
    • Nagaraja, A.K.1    Creighton, C.J.2    Yu, Z.3
  • 17
    • 59249101893 scopus 로고    scopus 로고
    • Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis
    • Noske A, Lindenberg JL, Darb-Esfahani S, et al (2008). Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis. Oncol Rep, 20, 1409-17.
    • (2008) Oncol Rep , vol.20 , pp. 1409-1417
    • Noske, A.1    Lindenberg, J.L.2    Darb-Esfahani, S.3
  • 18
    • 33751248513 scopus 로고    scopus 로고
    • Treatment issues in clear cell carcinoma of the ovary: A different entity?
    • Pectasides D, Pectasides E, Psyrri A, Economopoulos T (2006). Treatment issues in clear cell carcinoma of the ovary: A different entity? Oncologist, 11, 1089-94.
    • (2006) Oncologist , vol.11 , pp. 1089-1094
    • Pectasides, D.1    Pectasides, E.2    Psyrri, A.3    Economopoulos, T.4
  • 19
    • 8344281974 scopus 로고    scopus 로고
    • Targeting the molecular target of rapamycin (mTOR)
    • Rowinsky EK (2004). Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol, 16, 564-75.
    • (2004) Curr Opin Oncol , vol.16 , pp. 564-575
    • Rowinsky, E.K.1
  • 20
    • 33748194240 scopus 로고    scopus 로고
    • Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
    • Smolewski P (2006). Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs, 17, 487-94.
    • (2006) Anticancer Drugs , vol.17 , pp. 487-494
    • Smolewski, P.1
  • 21
    • 18744423896 scopus 로고    scopus 로고
    • Prognostic significance of tumor angiogenesis in epithelial ovarian cancer: in association with transforming growth factor beta and vascular endothelial growth factor
    • Sönmezer M, Güngör M, Ensari A, Ortaç F (2004). Prognostic significance of tumor angiogenesis in epithelial ovarian cancer: in association with transforming growth factor beta and vascular endothelial growth factor. Int J Gynecol Cancer, 14, 82-8.
    • (2004) Int J Gynecol Cancer , vol.14 , pp. 82-88
    • Sönmezer, M.1    Güngör, M.2    Ensari, A.3    Ortaç, F.4
  • 22
    • 27144461663 scopus 로고    scopus 로고
    • Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies
    • Springett GM, Bonham L, Hummer A, et al (2005). Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies. Cancer Res, 65, 9415-25.
    • (2005) Cancer Res , vol.65 , pp. 9415-9425
    • Springett, G.M.1    Bonham, L.2    Hummer, A.3
  • 23
    • 0034213974 scopus 로고    scopus 로고
    • Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy
    • Sugiyama T, Kamura T, Kigawa J, et al (2000). Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer, 88, 2584-9.
    • (2000) Cancer , vol.88 , pp. 2584-2589
    • Sugiyama, T.1    Kamura, T.2    Kigawa, J.3
  • 24
    • 62549099008 scopus 로고    scopus 로고
    • The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
    • Trinh XB, Tjalma WA, Vermeulen PB, et al (2009). The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. Br J Cancer, 100, 971-8.
    • (2009) Br J Cancer , vol.100 , pp. 971-978
    • Trinh, X.B.1    Tjalma, W.A.2    Vermeulen, P.B.3
  • 25
    • 25444488221 scopus 로고    scopus 로고
    • Modeling resistance to pathway-targeted therapy in ovarian cancer
    • Xing D, Orsulic S (2005). Modeling resistance to pathway-targeted therapy in ovarian cancer. Cell Cycle, 4, 1004-6.
    • (2005) Cell Cycle , vol.4 , pp. 1004-1006
    • Xing, D.1    Orsulic, S.2
  • 26
    • 33745936614 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis
    • Yagyu T, Tsuji Y, Haruta S, et al (2006). Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis. Int J Gynecol Cancer, 16, 1545-51.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 1545-1551
    • Yagyu, T.1    Tsuji, Y.2    Haruta, S.3
  • 27
    • 60749137451 scopus 로고    scopus 로고
    • Beyond chemotherapy: targeted therapies in ovarian cancer
    • Yap TA, Carden CP, Kaye SB (2009). Beyond chemotherapy: targeted therapies in ovarian cancer. Nat Rev Cancer, 9, 167-81.
    • (2009) Nat Rev Cancer , vol.9 , pp. 167-181
    • Yap, T.A.1    Carden, C.P.2    Kaye, S.B.3
  • 28
    • 68349157672 scopus 로고    scopus 로고
    • Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy
    • Zhang HY, Zhang PN, Sun H (2009). Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur J Obstet Gynecol Reprod Biol, 146, 81-6.
    • (2009) Eur J Obstet Gynecol Reprod Biol , vol.146 , pp. 81-86
    • Zhang, H.Y.1    Zhang, P.N.2    Sun, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.