Platelet-rich plasma to improve the bio-functionality of biomaterials

BioDrugs

Volumn 27, Issue 2, 2013, Pages 97-111

  Anitua, Eduardo ^a,b   Tejero, Ricardo ^b   Alkhraisat, Mohammad H ^b   Orive, Gorka ^b,c,d,e  

^a Implantology and Oral Rehabilitation   (Spain)

^b Biotechnology Institute BTI   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^e Instituto Eduardo Anitua   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; CALCIUM SULFATE; EPIDERMAL GROWTH FACTOR; FIBRIN; INORGANIC COMPOUND; INTERLEUKIN 1BETA; INTERLEUKIN 6; ORGANIC COMPOUND; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SOMATOMEDIN C; TITANIUM; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANORGANIC BOVINE BONE; BIOLOGICAL ACTIVITY; BONE GRAFT; BONE REGENERATION; CENTRIFUGATION; DOG; FEMUR; FRONTAL BONE; GOAT; HEMATOLOGICAL PROCEDURE; IMPLANT; IN VIVO STUDY; MANDIBLE; MAXILLA; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIUS; REGENERATIVE MEDICINE; REVIEW; SCID MOUSE; SKULL; THROMBOCYTE RICH PLASMA; TIBIA; TISSUE ENGINEERING; TRABECULAR BONE;

BIOCOMPATIBLE MATERIALS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PLATELET-RICH PLASMA; REGENERATIVE MEDICINE; TISSUE ENGINEERING; WOUND HEALING;

EID: 84877066674     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.1007/s40259-012-0004-3     Document Type: Review

References (82)

1. Anitua E, Sanchez M, Orive G. Potential of endogenous regenerative technology for in situ regenerative medicine. Adv Drug Deliv Rev. 2010;62(7-8):741-52.
2. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407(6801):242-8.
3. Graves DT, Valentin-Opran A, Delgado R, Valente AJ, Mundy G, Piche J. The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. Connect Tissue Res. 1989;23(2-3):209-18.
4. Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. Endogenous TGF-[beta] signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 2004;23(3):552-63.
5. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nature Med. 2003;9(6):669-76.
6. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg. 2002;84-A(12):2123-34.
7. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg. 2001;83-A Suppl 1(Pt 2):S151-8.
8. Orive G, Gascon AR, Hernandez RM, Dominguez-Gil A, Pedraz JL. Techniques: new approaches to the delivery of biopharmaceuticals. Trends Pharmacol Sci. 2004;25(7):382-7.
9. Guldberg RE. Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration. J Bone Miner Res. 2009;24(9):1507-11.
10. Tayalia P, Mooney DJ. Controlled growth factor delivery for tissue engineering. Adv Mater. 2009;21(32-33):3269-85.
11. Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, et al. The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation. 2003;107(10):1359-65.
12. Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr, et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology. 2003;60(1):69-73.
13. Ponce S, Orive G, Hernandez RM, Gascon AR, Canals JM, Munoz MT, et al. In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules. J Control Release. 2006;116(1):28-34.
14. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14(4):529-35.
15. Anitua E, Aguirre JJ, Algorta J, Ayerdi E, Cabezas AI, Orive G, et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. J Biomed Mater Res. 2008;84(2):415-21.
16. Sanchez M, Anitua E, Orive G, Mujika I, Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009;39(5):345-54.
17. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-46.
18. Lew WK, Weaver FA. Clinical use of topical thrombin as a surgical hemostat. Biologics. 2008;2(4):593-9.
19. Anitua E, Alkhraisat MH, Orive G. Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Release. 2012;157(1):29-38.
20. Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, Landesberg R. Differential growth factor retention by platelet-rich plasma composites. J Oral Maxillofac Surg. 2005;63(4):521-8.
21. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008;66(4):684-90.
22. Orive G, Zalduendo M, Anitua E. Growth factor kinetic study of PRGF-Endoret: the pioneering autologous technology in oral surgery for tissue regeneration. J Clin Periodontol. 2012;39(S13):348.
23. Grainger DJ, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC. Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Nature Med. 1995;1(9):932-7.
24. Hakimi M, Jungbluth P, Sager M, Betsch M, Herten M, Becker J, Windolf J, Wild M. Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs. Injury. 2010;41(7):717-23.
25. Mooren RE, Merkx MA, Bronkhorst EM, Jansen JA, Stoelinga PJ. The effect of platelet-rich plasma on early and late bone healing: an experimental study in goats. Int J Oral Maxillofac Surg. 2007;36(7):626-31.
26. Molina-Minano F, Lopez-Jornet P, Camacho-Alonso F, Vicente-Ortega V. Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits. Braz Oral Res. 2009;23(3):275-80.
27. Schlegel KA, Zimmermann R, Thorwarth M, Neukam F-W, Klongnoi B, Nkenke E, et al. Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(3):e15-25.
28. Trindade-Suedam IK, de Morais JA, Faeda RS, Leite FR, Tosoni GM, Neto CB, et al. Bioglass associated with leukocyte-poor platelet-rich plasma in the rabbit maxillary sinus: histomorphometric, densitometric, and fractal analysis. J Oral Implantol. 2010;36(5):333-43.
29. Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defects. Int J Oral Maxillofac Surg. 2008;37(6):542-9.
30. Guerra I, Morais Branco F, Vasconcelos M, Afonso A, Figueiral H, Zita R. Evaluation of implant osseointegration with different regeneration techniques in the treatment of bone defects around implants: an experimental study in a rabbit model. Clin Oral Implants Res. 2011;22(3):314-22.
31. Mooren RECM, Dankers ACA, Merkx MAW, Bronkhorst EM, Jansen JA, Stoelinga PJW. The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss: an experimental study in goats. Int J Oral Maxillofac Surg. 2010;39(4):371-8.
32. Torres J, Tamimi F, Tresguerres IF, Alkhraisat MH, Khraisat A, Blanco L, et al. Effect of combining platelet-rich plasma with anorganic bovine bone on vertical bone regeneration: early healing assessment in rabbit calvariae. Int J Oral Maxillofac Implants. 2010;25(1):123-9.
33. Camarini ET, Zanoni JN, Leite PC, Boos FB. Use of biomaterials with or without platelet-rich plasma in postextraction sites: a microscopic study in dogs. Int J Oral Maxillofac Implants. 2009;24(3):432-8.
34. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. Int J Oral Maxillofac Implants. 2004;19(1):59-65.
35. Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R, Schlegel KA. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects: an animal experiment. Clin Oral Implants Res. 2004;15(2):187-93.
36. Sugimori E, Shintani S, Ishikawa K, Hamakawa H. Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects. Dent Mater J. 2006;25(3):591-6.
37. Intini G, Andreana S, Intini FE, Buhite RJ, Bobek LA. Calcium sulfate and platelet-rich plasma make a novel osteoinductive biomaterial for bone regeneration. J Transl Med. 2007;5:13.
38. Shi B, Zhou Y, Wang YN, Cheng XR. Alveolar ridge preservation prior to implant placement with surgical-grade calcium sulfate and platelet-rich plasma: a pilot study in a canine model. Int J Oral Maxillofac Implants. 2007;22(4):656-65.
39. Nair MB, Varma HK, Menon KV, Shenoy SJ, John A. Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma. Acta Biomater. 2009;5(5):1742-55.
40. Plachokova AS, van den Dolder J, van den Beucken JJ, Jansen JA. Bone regenerative properties of rat, goat and human platelet-rich plasma. Int J Oral Maxillofac Surg. 2009;38(8):861-9.
41. Kim B-K, Kim S-G, Kim S-Y, Lim S-C, Kim Y-K. A comparison of bone generation capability in rabbits using tooth ash and plaster of Paris with platelet-rich plasma or fibrin sealant. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(3):e8-14.
42. Suba Z, Takács D, Gyulai-Gaál S, Kovács K. Facilitation of beta-tricalcium phosphate-induced alveolar bone regeneration by platelet-rich plasma in beagle dogs: a histologic and histomorphometric study. Int J Oral Maxillofac Implants. 2004;19(6):832-8.
43. Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda K, et al. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres. Tissue Eng. 2007;13(1):147-58.
44. Kurita J, Miyamoto M, Ishii Y, Aoyama J, Takagi G, Naito Z, et al. Enhanced vascularization by controlled release of platelet-rich plasma impregnated in biodegradable gelatin hydrogel. Ann Thorac Surg. 2011;92(3):837-44.
45. Bi L, Cheng W, Fan H, Pei G. Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma. Biomaterials. 2010;31(12):3201-11.
46. Rai B, Ho KH, Lei Y, Si-Hoe KM, Jeremy Teo CM, Yacob KB, et al. Polycaprolactone-20 % tricalcium phosphate scaffolds in combination with platelet-rich plasma for the treatment of critical-sized defects of the mandible: a pilot study. J Oral Maxillofac Surg. 2007;65(11):2195-205.
47. Kasten P, Vogel J, Luginbuhl R, Niemeyer P, Weiss S, Schneider S, et al. Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics. Cells Tissues Organs. 2006;183(2):68-79.
48. Pieri F, Lucarelli E, Corinaldesi G, Fini M, Aldini NN, Giardino R, Donati D, Marchetti C. Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs. J Oral Maxillofac Surg. 2009;67(2):265-72.
49. Behnia H, Khojasteh A, Kiani MT, Khoshzaban A, Abbas FM, Bashtar M, et al. Bone regeneration with a combination of nanocrystalline hydroxyapatite silica gel, platelet-rich growth factor, and mesenchymal stem cells: a histologic study in rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012. doi: 10.1016/j.oooo.2011.09.034.
50. Metzler P, von Wilmowsky C, Zimmermann R, Wiltfang J, Schlegel KA. The effect of current used bone substitution materials and platelet-rich plasma on periosteal cells by ectopic site implantation: an in-vivo pilot study. J Craniomaxillofac Surg. 2012;40(5):409-15.
51. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone. 2004;34(4):665-71.
52. Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials. 2009;30(28):4956-66.
53. Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res. 2008;19(6):539-45.
54. Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andía I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227-34.
55. Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28(31):4551-60.
56. Anitua E, Andia Ortiz I. BTI implant system: the first implant system with a bioactive surface. Maxillaris. 2001;39:2-7.
57. Anitua EA. Enhancement of osseointegration by generating a dynamic implant surface. J Oral Implantol. 2006;32(2):72-6.
58. Anitua E, Orive G, Aguirre JJ, Ardanza B, Andia I. 5-year clinical experience with BTI dental implants: risk factors for implant failure. J Clin Periodontol. 2008;35(8):724-32.
59. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc. 2003;69(10):664.
60. Chaput CD, Patel KV, Brindley GW, Roux MA, Hu N, Dmitriev A, et al. Influence of a platelet concentrate on prosthetic bone ingrowth in a rabbit model. J Surg Orthop Adv. 2007 Winter;16(4):159-63.
61. Thor A, Rasmusson L, Wennerberg A, Thomsen P, Hirsch JM, Nilsson B, et al. The role of whole blood in thrombin generation in contact with various titanium surfaces. Biomaterials. 2007;28(6):966-74.
62. Schmaier AH. Contact activation: a revision. Thromb Haemost. 1997;78(1):101-7.
63. 2. Biomaterials. 1991;12(6):593-6.
64. Evans-Nguyen KM, Schoenfisch MH. Fibrin proliferation at model surfaces: influence of surface properties. Langmuir. 2005;21(5):1691-4.
65. Cucuianu M, Trif I. The role of platelets and leukocytes in coagulation and fibrinolysis. Rev Roum Physiol. 1992;29(1-2):33-8.
66. Nikolidakis D, van den Dolder J, Wolke JG, Jansen JA. Effect of platelet-rich plasma on the early bone formation around Ca-P-coated and non-coated oral implants in cortical bone. Clin Oral Implants Res. 2008;19(2):207-13.
67. Kanagaraja S, Lundstrom I, Nygren H, Tengvall P. Platelet binding and protein adsorption to titanium and gold after short time exposure to heparinized plasma and whole blood. Biomaterials. 1996;17(23):2225-32.
68. Anitua E, Orive G, Pla R, Roman P, Serrano V, Andia I. The effects of PRGF on bone regeneration and on titanium implant osseointegration in goats: a histologic and histomorphometric study. J Biomed Mater Res. 2009;91(1):158-65.
69. Fontana S, Olmedo DG, Linares JA, Guglielmotti MB, Crosa ME. Effect of platelet-rich plasma on the peri-implant bone response: an experimental study. Implant Dent. 2004;13(1):73-8.
70. Fuerst G, Gruber R, Tangl S, Sanroman F, Watzek G. Enhanced bone-to-implant contact by platelet-released growth factors in mandibular cortical bone: a histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18(5):685-90.
71. de Vasconcelos Gurgel BC, Goncalves PF, Pimentel SP, Ambrosano GM, Nociti Junior FH, Sallum EA, et al. Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs. Clin Oral Implants Res. 2007;18(5):649-54.
72. Garcia RV, Gabrielli MA, Hochuli-Vieira E, Spolidorio LC, Filho JG, Neto FA, et al. Effect of platelet-rich plasma on peri-implant bone repair: a histologic study in dogs. J Oral Implantol. 2010;36(4):281-90.
73. Schlegel KA, Kloss FR, Kessler P, Schultze-Mosgau S, Nkenke E, Wiltfang J. Bone conditioning to enhance implant osseointegration: an experimental study in pigs. Int J Oral Maxillofac Implants. 2003;18(4):505-11.
74. Zechner W, Tangl S, Tepper G, Furst G, Bernhart T, Haas R, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18(1):15-22.
75. Jensen TB, Bechtold JE, Chen X, Vestermark M, Soballe K. No effect of autologous growth factors (AGF) around ungrafted loaded implants in dogs. Int Orthop. 2010;34(6):925-30.
76. 2-surfaces: influence of surface topography and oxide thickness on leukocyte adhesion and activation. Biomaterials. 2001;22(14):1987-96.
77. Vogler EA, Siedlecki CA. Contact activation of blood-plasma coagulation. Biomaterials. 2009;30(10):1857-69.
78. Kammerer PW, Gabriel M, Al-Nawas B, Scholz T, Kirchmaier CM, Klein MO. Early implant healing: promotion of platelet activation and cytokine release by topographical, chemical and biomimetical titanium surface modifications in vitro. Clin Oral Implants Res. 2012;23(4):504-10.
79. Park JY, Gemmell CH, Davies JE. Platelet interactions with titanium: modulation of platelet activity by surface topography. Biomaterials. 2001;22(19):2671-82.
80. Rajtar G, Livio M, Merino J, de Gaetano G. Malondialdehyde formation in rat platelet-rich plasma: I. A kinetic approach. Thromb Haemost. 1980;44(2):49-51.
81. Kasten P, Vogel J, Beyen I, Weiss S, Niemeyer P, Leo A, et al. Effect of platelet-rich plasma on the in vitro proliferation and osteogenic differentiation of human mesenchymal stem cells on distinct calcium phosphate scaffolds: the specific surface area makes a difference. J Biomater Appl. 2008;23(2):169-88.
82. Clemmons RM, Bliss EL, Dorsey-Lee MR, Seachord CL, Meyers KM. Platelet function, size and yield in whole blood and in platelet-rich plasma prepared using differing centrifugation force and time in domestic and food-producing animals. Thromb Haemost. 1983;50(4):838-43.