Cell-based microfluidic device for screening anti-proliferative activity of drugs in vascular smooth muscle cells

Biomedical Microdevices

Volumn 14, Issue 6, 2012, Pages 1129-1140

  Rodriguez Rodriguez, R ^a   Munoz Berbel X ^b   Demming, S ^c   Buttgenbach S ^c   Herrera, M D ^a   Llobera, A ^b,c  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE MICROELECTRÓNICA DE BARCELONA   (Spain)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Antiproliferative drug delivery; Cell proliferation assay; Microfluidic device; Readout grid integrated parallel microbioreactors; Vascular smooth muscle cells

Indexed keywords

CELL PROLIFERATION; CELLS; CYTOLOGY; DRUG DELIVERY; FLUIDIC DEVICES; HYBRID SYSTEMS; MICROCHANNELS; MICROFLUIDICS;

ANTI-PROLIFERATIVE; ANTI-PROLIFERATIVE ACTIVITIES; EXPERIMENTAL CONDITIONS; LITHOGRAPHIC METHODS; MICRO BIOREACTOR; MICRO-FLUIDIC DEVICES; MORPHOLOGY AND SIZE; VASCULAR SMOOTH MUSCLE CELLS;

MUSCLE;

COLCHICINE; CURCUMIN; DIMETICONE; NYLON; POLY(DIMETHYLSILOXANE) POLYAMIDE COPOLYMER; POLY(DIMETHYLSILOXANE)-POLYAMIDE COPOLYMER;

ANIMAL CELL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOREACTOR; BIOREACTOR DESIGN; CELL CULTURE; CELL MOTILITY; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; IC 50; INTERMETHOD COMPARISON; MALE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; READOUT GRID INTEGRATED PARALLEL MICROBIOREACTOR; SINGLE CELL ANALYSIS; SMOOTH MUSCLE FIBER; VALIDATION PROCESS; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA; CHEMISTRY; CYTOLOGY; EQUIPMENT DESIGN; INSTRUMENTATION; METHODOLOGY; MICROFLUIDIC ANALYSIS;

ANIMALS; AORTA; BIOREACTORS; CELL PROLIFERATION; COLCHICINE; CURCUMIN; DIMETHYLPOLYSILOXANES; EQUIPMENT DESIGN; MICROFLUIDIC ANALYTICAL TECHNIQUES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NYLONS; RATS; SINGLE-CELL ANALYSIS;

EID: 84877063060     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-012-9679-y     Document Type: Article

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