Standard or hypofractionated radiotherapy in the postoperative treatment of breast cancer: A retrospective analysis of acute skin toxicity and dose inhomogeneities

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Tortorelli, Grazia ^a   Di Murro, Luana ^a   Barbarino, Rosaria ^a   Cicchetti, Sara ^a   di Cristino, Daniela ^a   Falco, Maria Daniela ^a   Fedele, Dahlia ^a   Ingrosso, Gianluca ^a   Janniello, Dania ^a   Morelli, Pasquale ^a   Murgia, Alessandra ^a   Ponti, Elisabetta ^a   Terenzi, Sara ^a   Tolu, Barbara ^a   Santoni, Riccardo ^a  

^a TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TAMOXIFEN; TRASTUZUMAB;

ACUTE TOXICITY; ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL EVALUATION; DESQUAMATION; DOSIMETRY; FEASIBILITY STUDY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; PARTIAL MASTECTOMY; POSTOPERATIVE CARE; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION SAFETY; RETROSPECTIVE STUDY; SKIN MANIFESTATION; SKIN TOXICITY; TREATMENT PLANNING; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; DOSE FRACTIONATION; ERYTHEMA; FEMALE; HUMANS; MIDDLE AGED; MULTIVARIATE ANALYSIS; RADIODERMATITIS; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, CONFORMAL; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84877058081     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-230     Document Type: Article

References (27)

1. Clarke M, Collins R, Darby S, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, Mackinnon E, McGale P, McHugh T, Peto R, Taylor C, Wang Y. Early Breast cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005, 366:2087-2106.
2. Matzinger O, Heimsoth I, Poortmans P, Collette L, Struikmans H, Van Den Bogaert W, Fourquet A, Bartelink H, Ataman F, Gulyban A, Pierart M, Van Tienhoven G. EORTC Radiation Oncology and Breast Cancer Groups. Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast Cancer (EORTC trial 22922/10925). Acta Oncol 2010, 49:24-34. 10.3109/02841860903352959, 20100142.
3. Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, Vu TT, Truong P, Ackerman I, Paszat L. A Multicenter randomised trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008, 26:2085-2092. 10.1200/JCO.2007.15.2488, 18285602.
4. Morganti AG, Cilla S, Valentini V, Digesù C, Macchia G, Deodato F, Ferrandina G, Cece MG, Cirocco M, Garganese G, Di Lullo L, Traficante D, Scarabeo F, Panunzi S, De Gaetano A, Sallustio G, Cellini N, Sofo L, Piermattei A, Scambia G. Phase I-II studies on accelerated IMRT in breast carcinoma: technical comparison and acute toxicity in 332 patients. Radiother Oncol 2009, 90:86-92. 10.1016/j.radonc.2008.10.017, 19010560.
5. Croog VJ, Wu AJ, McCormick B, Beal KP. Accelerated whole breast irradiation with intensity-modulated radiotherapy to the prone breast. Int J Radia Oncol Biol Phys 2009, 73:88-93.
6. Bucholoz TA, Gurgoze E, Bice WS, Prestidge BR. Dosimetric analysis of intact breast irradiation in off-axis planes. Int J Radia Oncol Biol Phys 1997, 39:261-67.
7. Chen MF, Chen WC, Lai CH, Hung CH, Liu KC, Cheng YH. Predective factors of radiation-induced skin toxicity in breast cancer patients. BMC Cancer 2010, 10:508. 10.1186/1471-2407-10-508, 2955039, 20860847.
8. Dorn PL, Corbin KS, Al-HAllaq H, Hasan Y, Chmura SJ. Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients. Int J Radiat Oncol Biol Phys 2012 May 1, 83(1):79-83.
9. Fowler JF. 21 years of Biologically Effective Dose. Br J Radiol 2010, 83:554-568. 10.1259/bjr/31372149, 3473681, 20603408.
10. ICRU Prescribing, recording, and reporting photon beam therapy. ICRU report. Volume 50 1993, Bethesda: International Commission on Radiation Units and Measurements, ICRU.
11. ICRU Prescribing, recording, and reporting photon beam therapy (supplement to ICRU report 50). ICRU Report. Volume 62 1999, Bethesda: International Commission on Radiation Units and Measurements, ICRU.
12. Falco MD, D'Andrea M, Lo Bosco A, Rebuzzi M, Ponti E, Tolu B, Tortorelli G, Barbarino R, Di Murro L, Santoni R. Is the in vivo dosimetry with the OneDosePlusTM system able to detect intra-fraction motion?. A retrospective analysis of in vivo data from breast and prostate patients. Radiat Oncol 2012, 7:97.
13. Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C. Long-term results of hypofractionated radiation therapy for breast cancer. N England J Med 2010, 362:513-520.
14. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DA, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR. The UK Standardization of Breast Radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet Oncol 2008, 9:331-341. 2323709, 18356109.
15. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DA, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR. The UK Standardisation of Breast Radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet 2008, 371:1098-1107. 2277488, 18355913.
16. White JR, Khalid N, Tao ML, Pierce LJ, DeRobertis A, Crozier C, Owen JB, Wilson JF. QRRO 2007 Practice Survey Documents Dramatic Technical Changes in How Radiotherapy for operable Breast Cancer is Delivered. Int J Radiat Oncol Biol Phys 2010, 78:S4.
17. Dwyer P, Hickey B, Burmeister E, Burmeister B. Hypofractionated whole-breast radiotherapy: Impact on departmental waiting times an cost. J Med Imaging Radiat Oncol 2010, 54:229-234. 10.1111/j.1754-9485.2010.02163.x, 20598011.
18. Corbin KS, Dorn PL, Jain SK, Al-Hallaq HA, Hasan Y, Chmura SJ. Hypofractionated Radiotherapy Does Not Increase Acute Toxicity in Large-Breasted Women: Results From a Prospectively Collected Series. Am J Clin Oncol 2013, Epub ahead of print.
19. Kraus-Tiefenbacher U, Sfintizky A, Welzel G, Simeonova A, Sperk E, Siebenlist K, Mai S, Wenz F. Factors of influence on acute skin toxicity of breast cancer patients treated with standard external beam radiotherapy (EBRT) after breast conserving surgery (BCS). Radiat Oncol 2012, 7(1):217. Epub ahead of print, 10.1186/1748-717X-7-217, 3598440, 23249653.
20. Freedman GM, Anderson PR, Li J, Eisenberg DF, Hanlon AL, Wang L, Nicolaou N. Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer. Am J Clin Oncol 2006 Feb, 29(1):66-70.
21. Vicini FA, Sharpe M, Kestin L, Martinez A, Mitchell CK, Wallace MF, Matter R, Wong J. Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2002, 54(5):1336-44. 10.1016/S0360-3016(02)03746-X, 12459355.
22. Harsolia A, Kestin L, Grills I, Wallace M, Jolly S, Jones C, Lala M, Martinez A, Schell S, Vicini FA. Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy. Int J Radiat Oncol Biol Phys 2007, 68(5):1375-80. Epub 2007 Jun 4, 10.1016/j.ijrobp.2007.02.044, 17544598.
23. Back M, Guerrieri M, Wratten C, Steigler A. Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancer. Clin Oncol (R Coll Radiol) 2004, 16(1):12-6.
24. Taylor ME, Perez CA, Halverson KJ, Kuske RR, Philpott GW, Garcia DM, Mortimer JE, Myerson RJ, Radford D, Rush C. Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 1995, 31(4):753-64. 10.1016/0360-3016(94)00480-3, 7860386.
25. Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, Peckitt C, Reise S, Ross G, Sharp G, Symonds-Tayler R, Tait D, Yarnold J. Breast Technology Group. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007, 82:254-264. 10.1016/j.radonc.2006.12.008, 17224195.
26. Barnett GC, Wilkinson J, Moody AM, Wilson CB, Sharma R, Klager S, Hoole ACF, Twyman N, Burnet NG, Coles CE. A randomized controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: Baseline characterisics and dosimetry results
27. Mangoni M, Bisanzi S, Carozzi F, Sani C, Biti G, Livi L, Barletta E, Costantini AS, Gorini G. Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys 2011, 81:52-58. 10.1016/j.ijrobp.2010.04.023, 20708344.