Soluble CD40 ligand impairs the anti-platelet function of peripheral blood angiogenic outgrowth cells via increased production of reactive oxygen species

Thrombosis and Haemostasis

Volumn 109, Issue 5, 2013, Pages 940-947

  Khzam, Lara Bou ^a   Hachem, Ahmed ^a   Zaid, Younes ^a   Boulahya, Rahma ^a   Mourad, Walid ^b   Merhi, Yahye ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

CD40; CD40L; Early outgrowth cells; Platelets; Reactive oxygen species

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; NITRIC OXIDE; PROSTACYCLIN; REACTIVE OXYGEN METABOLITE; SOLUBLE CD40 LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EARLY OUTGROWTH CELL; FLUORESCENCE MICROSCOPY; FLUOROMETRY; HUMAN; HUMAN CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIGENS, CD40; APOPTOSIS; BLOOD PLATELETS; CD40 LIGAND; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; EPOPROSTENOL; FREE RADICAL SCAVENGERS; HUMANS; LEUKOCYTES, MONONUCLEAR; NITRIC OXIDE; PLATELET AGGREGATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS;

EID: 84877056280     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-09-0679     Document Type: Article

References (43)

1. Kawamoto A, Losordo DW. Endothelial progenitor cells for cardiovascular regeneration. Trends Cardiovasc Med 2008; 18: 33-37.
2. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967.
3. Daub K, Langer H, Seizer P, et al. Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J 2006; 20: 2559-2561.
4. de Boer HC, Verseyden C, Ulfman LH, et al. Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype. Arterioscler Thromb Vasc Biol 2006; 26: 1653-1659.
5. Lev EI, Estrov Z, Aboulfatova K, et al. Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix. Thromb Haemost 2006; 96: 498-504.
6. Massberg S, Konrad I, Schurzinger K, et al. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 2006; 203: 1221-1233.
7. Stellos K, Langer H, Daub K, et al. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation 2008; 117: 206-215.
8. Stellos K, Gnerlich S, Kraemer B, et al. Platelet interaction with progenitor cells: vascular regeneration or inquiry? Pharmacol Rep 2008; 60: 101-108.
9. Mause SF, Ritzel E, Liehn EA, et al. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 2010; 122: 495-506.
10. Abou-Saleh H, Yacoub D, Theoret JF, et al. Endothelial progenitor cells bind and inhibit platelet function and thrombus formation. Circulation 2009; 120: 2230-2239.
11. Aoki J, Serruys PW, van Beusekom H, et al. Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth-First In Man) Registry. J Am Coll Cardiol 2005; 45: 1574-1579.
12. Kaushal S, Amiel GE, Guleserian KJ, et al. Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med 2001; 7: 1035-1040.
13. Shirota T, He H, Yasui H, et al. Human endothelial progenitor cell-seeded hybrid graft: proliferative and antithrombogenic potentials in vitro and fabrication processing. Tissue engineering 2003; 9: 127-136.
14. Soehnlein O, Wantha S, Simsekyilmaz S, et al. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Science translational medicine 2011; 3: 103-198.
15. Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
16. Hristov M, Gumbel D, Lutgens E, et al. Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury. Circulation 2010; 121: 315-324.
17. Hassan GS, Merhi Y, Mourad WM. CD154 and its receptors in inflammatory vascular pathologies. Trends Immunol 2009; 30: 165-172.
18. Karmann K, Hughes CC, Schechner J, et al. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci U S A 1995; 92: 4342-4346.
19. Rizvi M, Pathak D, Freedman JE, et al. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med 2008; 14: 530-538.
20. Mach F, Schonbeck U, Fabunmi RP, et al. T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: implications for tubule formation. Am J Pathol 1999; 154: 229-238.
21. Schonbeck U, Mach F, Sukhova GK, et al. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells. Am J Pathol 2000; 156: 7-14.
22. Aukrust P, Damas JK, Solum NO. Soluble CD40 ligand and platelets: self-perpetuating pathogenic loop in thrombosis and inflammation? J Am Coll Cardiol 2004; 43: 2326-2328.
23. Urbich C, Dernbach E, Aicher A, et al. CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation 2002; 106: 981-986.
24. Chen C, Chai H, Wang X, et al. Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood 2008; 112: 3205-3216.
25. Longo CR, Arvelo MB, Patel VI, et al. A20 protects from CD40-CD40 ligandmediated endothelial cell activation and apoptosis. Circulation 2003; 108: 1113-1118.
26. Chakrabarti S, Blair P, Freedman JE. CD40-40L signalling in vascular inflammation. J Biol Chem 2007; 282: 18307-18317.
27. Mead LE, Prater D, Yoder MC, et al. Isolation and characterisation of endothelial progenitor cells from human blood. Curr Protoc Stem Cell Biol 2008; Chapter 2: Unit 2C 1.
28. Yamamoto K, Takahashi T, Asahara T, et al. Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J Appl Physiol 2003; 95: 2081-2088.
29. Hur J, Yoon CH, Kim HS, et al. Characterisation of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004; 24: 288-293.
30. Sieveking DP, Ng MK. Cell therapies for therapeutic angiogenesis: back to the bench. Vasc Med 2009; 14: 153-166.
31. Ingram DA, Mead LE, Tanaka H, et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004; 104: 2752-2760.
32. Prater DN, Case J, Ingram DA, et al. Working hypothesis to redefine endothelial progenitor cells. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK 2007; 21: pp. 1141-1149.
33. Pearson JD. Endothelial progenitor cells - hype or hope? J Thromb Haemost 2009; 7: 255-262.
34. Zhang Y, Ingram DA, Murphy MP, et al. Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol 2009; 296: H1675-1682.
35. Krenning G, van der Strate B, Schipper M, et al. CD34(+) Cells Augment Endothelial Cell Differentiation of CD14(+) Endothelial Progenitor Cells in vitro. J Cell Mol Med 2009; 13: 2521-2533.
36. Yoon CH, Hur J, Park KW, et al. Synergistic neovascularisation by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases. Circulation 2005; 112: 1618-1627.
37. Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008; 28: 1584-1595.
38. Rehman J, Li J, Orschell CM, et al. Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107: 1164-1169.
39. Co M, Tay E, Lee CH, et al. Use of endothelial progenitor cell capture stent (Genous Bio-Engineered R Stent) during primary percutaneous coronary intervention in acute myocardial infarction: intermediate- to long-term clinical follow- up. Am Heart J 2008; 155: 128-132.
40. Antoniades C, Bakogiannis C, Tousoulis D, et al. The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol 2009; 54: 669-677.
41. Lievens D, Eijgelaar WJ, Biessen EA, et al. The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost 2009; 102: 206-214.
42. de Lemos JA, Zirlik A, Schonbeck U, et al. Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study. Arterioscler Thromb Vasc Biol 2005; 25: 2192-2196.
43. Lievens D, Zernecke A, Seijkens T, et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010; 116: 4317-4327.