Association of African genetic admixture with resting metabolic rate and obesity among women

Obesity Research

Volumn 11, Issue 7, 2003, Pages 904-911

  Fernández, José R ^a   Shriver, Mark D ^b   Beasley, T Mark ^a   Rafla Demetrious, Nashwa ^c   Parra, Esteban ^b   Albu, Jeanine ^c   Nicklas, Barbara ^d,e   Ryan, Alice S ^e   McKeigue, Paul M ^f   Hoggart, Clive L ^f   Weinsier, Roland L ^a   Allison, David B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Admixture; African Americans; Ancestry informative markers; Genetics; Resting metabolic rate

Indexed keywords

APOLIPOPROTEIN A1; G PROTEIN BETA3 SUBUNIT; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BASAL METABOLIC RATE; BAYES THEOREM; BODY COMPOSITION; BODY MASS; BONE DENSITY; CALORIMETRY; CHROMOSOME 1; CHROMOSOME 11; CHROMOSOME 12; FEMALE; GENETIC LINKAGE; GENETIC MARKER; GENETICS; GENOTYPE; HUMAN; NEGRO; OBESITY; PHENOTYPE; STATISTICAL MODEL;

AFRICAN CONTINENTAL ANCESTRY GROUP; APOLIPOPROTEIN A-I; BASAL METABOLISM; BAYES THEOREM; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; CALORIMETRY, INDIRECT; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENETIC MARKERS; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); OBESITY; PHENOTYPE;

EID: 0141916495     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2003.124     Document Type: Article

References (29)

1. Allison DB, Edlen-Nezin L, Clay-Williams G. Obesity among African American women: prevalence, consequences, causes, and developing research. Womens Health. 1997;3:243-74.
2. Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am. J Clin Nutr. 2000;72:694-701.
3. Nicklas BJ, Berman DM, Davis DC, Dobrovolny CL, Dennis KE. Racial differences in metabolic predictors of obesity among postmenopausal women. Obes Res. 1999;7:463-8.
4. Hunter GR, Weinsier RL, Darnell BE, Zuckerman PA, Goran MI. Racial differences in energy expenditure and aerobic fitness in premenopausal women. Am. J Clin Nutr. 2000;71:500-6.
5. Lovejoy JC, Champagne CM, Smith SR, de Jonge L, Xie H. Ethnic differences in dietary intakes, physical activity, and energy expenditure in middle-aged, premenopausal women: the Healthy Transitions Study. Am. J Clin Nutr. 2001;74: 90-5.
6. Wright NM, Papadea N, Veldhuis JD, Bell NH. Growth hormone secretion and bone mineral density in prepubertal black and white boys. Calcif Tissue Int. 2002;70:146-52.
7. Wagner DR, Heyward VH. Measures of body composition in blacks and whites: a comparative review. Am. J Clin Nutr. 2000;71:1392-402.
8. Shriver MD, Smith MW, Jin L, et al. Ethnic-affiliation estimation by use of population-specific DNA markers. Am. J Hum Genet. 1997;60:957-64.
9. McKeigue PM. Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am. J Hum Genet. 1997;60:188-96.
10. McKeigue PM, Carpenter JR, Parra EJ, Shriver MD. Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations. Ann. Hum Genet. 2000;64:171-86.
11. Williams RC, Long JC, Hanson RL, Sievers ML, Knowler WC. Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians. Am. J Hum Genet. 2000;66:527-38.
12. Weinsier RL, Hunter GR, Desmond RA, Byrne NM, Zuckerman PA, Darnell BE. Free-living activity energy expenditure in women successful and unsuccessful at maintaining a normal body weight. Am. J Clin Nutr. 2002;75:499-504.
13. Albu J, Shur M, Curi M, Murphy L, Heymsfield SB, Pi-Sunyer FX. Resting metabolic rate in obese, premenopausal black women. Am. J Clin Nutr. 1997;66:531-8.
14. Akey JM, Sosnoski D, Parra E, et al. Melting curve analysis of SNPs (McSNP): a gel-free and inexpensive approach for SNP genotyping. Biotechniques. 2001;30:358-67.
15. Parra EJ, Kittles RA, Argyropoulos G, et al. Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina. Am. J Phys Anthropol. 2001;114:18-29.
16. Shriver MD, Parra EJ, Dios S, et al. Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet. 2003;112:387-99.
17. Hanis CL, Chakraborty R, Ferrell RE, Schull WJ. Individual admixture estimates: disease associations and individual risk of diabetes and gallbladder disease among Mexican-Americans in Starr County, Texas. Am J Phys Anthropol. 1986;70:433-41.
18. Flegal KM. Is an inverted weight-height index a better index of body fatness? Obes Res. 1997;5:93S (abstr).
19. Fernandez JR, Heo M, Heymsfield SB, et al. Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans? Am. J Clin Nutr. 2003;77:71-5.
20. McKeigue PM. Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. Am. J Hum Genet. 1998;63:241-51.
21. Luke A, Rotimi CN, Adeyemo AA, et al. Comparability of resting energy expenditure in Nigerians and U. S. blacks. Obes Res. 2000;8:351-9.
22. Goran MI, Nagy TR, Gower BA, et al. Influence of sex, seasonality, ethnicity, and geographic location on the components of total energy expenditure in young children: implications for energy requirements. Am J Clin Nutr. 1998;68:675-82.
23. Hegele RA, Cao H, Harris SB, Zinman B, Hanley AJ, Anderson CM. Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians. Physiol Genomics. 2000;3:39-44.
24. Hegele RA, Cao H, Huff MW, Anderson CM. LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration. J Clin Endocrinol Metab. 2000;85:3089-93.
25. Vionnet N, Hani E, Dupont S, et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet. 2000;67:1470-80.
26. Comings DE, Flanagan SD, Dietz G, Muhleman D, Knell E, Gysin R. The dopamine D2 receptor (DRD2) as a major gene in obesity and height. Biochem Med Metab Biol. 1993;50:176-85.
27. Spitz MR, Detry MA, Pillow P, et al. Variant alleles of the D2 dopamine receptor gene and obesity. Nutr Res. 2000;20:371-80.
28. Hegele RA, Anderson C, Young TK, Connelly PW. G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res. 1999;9:972-7.
29. Siffert W, Forster P, Jockel KH, et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol. 1999;10:1921-30.